SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4eh1 FLAVOHEMOPROTEIN
(Vibrio
cholerae) 		3 / 3 ASP A 204
PHE A 205
LEU A 207
 None
 0.68A 2zi9A-4eh1A:
undetectable		 2zi9A-4eh1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4eh1 FLAVOHEMOPROTEIN
(Vibrio
cholerae) 		4 / 5 TYR A 233
ALA A 229
TYR A 111
MET A 130
 SO4  A 304 (-4.3A)
None
None
None
 0.91A 3d91A-4eh1A:
undetectable		 3d91A-4eh1A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4eh1 FLAVOHEMOPROTEIN
(Vibrio
cholerae) 		5 / 12 GLN A 174
GLN A 131
SER A 153
GLU A 162
ALA A 160
 None
 1.45A 3t7sC-4eh1A:
2.9		 3t7sC-4eh1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4eh1 FLAVOHEMOPROTEIN
(Vibrio
cholerae) 		4 / 6 LEU A 137
GLN A  36
PRO A  37
TYR A 111
 None
 1.37A 3vkxA-4eh1A:
undetectable		 3vkxA-4eh1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4eh1 FLAVOHEMOPROTEIN
(Vibrio
cholerae) 		5 / 11 ASP A 204
VAL A 118
VAL A 145
LEU A 137
TRP A 172
 None
 1.46A 4yhaC-4eh1A:
undetectable		 4yhaC-4eh1A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4eh1 FLAVOHEMOPROTEIN
(Vibrio
cholerae) 		4 / 6 ASP A 180
ARG A 179
GLY A 189
GLU A 190
 None
 0.89A 5cdqA-4eh1A:
undetectable
5cdqC-4eh1A:
undetectable
5cdqD-4eh1A:
undetectable		 5cdqA-4eh1A:
17.88
5cdqC-4eh1A:
17.88
5cdqD-4eh1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4eh1 FLAVOHEMOPROTEIN
(Vibrio
cholerae) 		4 / 8 GLY A 126
CYH A 208
GLY A 209
GLU A 234
 None
None
None
FAD  A 301 (-3.6A)
 0.48A 5vw5A-4eh1A:
22.8		 5vw5A-4eh1A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4eh1 FLAVOHEMOPROTEIN
(Vibrio
cholerae) 		5 / 10 TYR A 206
LEU A 137
TYR A 111
VAL A 145
GLY A 144
 None
None
None
None
GOL  A 306 ( 4.2A)
 1.44A 5zbdA-4eh1A:
4.3		 5zbdA-4eh1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4eh1 FLAVOHEMOPROTEIN
(Vibrio
cholerae) 		5 / 10 TYR A 206
LEU A 137
TYR A 111
VAL A 145
GLY A 144
 None
None
None
None
GOL  A 306 ( 4.2A)
 1.46A 5zbdB-4eh1A:
undetectable		 5zbdB-4eh1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4eh1 FLAVOHEMOPROTEIN
(Vibrio
cholerae) 		4 / 8 THR A 128
GLN A 131
ARG A  70
SER A  16
 FAD  A 301 (-3.2A)
None
None
None
 1.12A 6c06C-4eh1A:
0.8		 6c06C-4eh1A:
undetectable