SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ehi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		5 / 11 PHE A 334
ILE A 322
ALA A 323
LEU A 305
ALA A 330
 None
 1.40A 1jb0B-4ehiA:
undetectable		 1jb0B-4ehiA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		4 / 4 VAL A 374
ALA A 406
LEU A 252
PHE A 407
 None
 0.99A 1q97B-4ehiA:
undetectable		 1q97B-4ehiA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		4 / 4 MET A 186
ALA A 183
TYR A 181
ILE A 182
 None
 1.31A 1upfD-4ehiA:
3.4		 1upfD-4ehiA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		4 / 4 LEU A 279
SER A 282
TYR A 283
LEU A 309
 None
 0.95A 1xz1A-4ehiA:
undetectable		 1xz1A-4ehiA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		4 / 4 LEU A 279
SER A 282
TYR A 283
LEU A 309
 None
 0.95A 1xz3A-4ehiA:
undetectable		 1xz3A-4ehiA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		3 / 3 GLY A 375
GLU A 373
ASP A 377
 None
 0.65A 2b25B-4ehiA:
2.1		 2b25B-4ehiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		4 / 5 LEU A  20
ILE A  27
LEU A  28
SER A  29
 None
 0.64A 2byoA-4ehiA:
undetectable		 2byoA-4ehiA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		5 / 11 THR A 503
LEU A 398
MET A 402
TYR A 501
LEU A 395
 None
 1.48A 2idkA-4ehiA:
2.4
2idkB-4ehiA:
2.6
2idkC-4ehiA:
undetectable
2idkD-4ehiA:
undetectable		 2idkA-4ehiA:
20.90
2idkB-4ehiA:
20.90
2idkC-4ehiA:
20.90
2idkD-4ehiA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		4 / 6 LEU A 350
PHE A 231
ILE A 246
ALA A 300
 None
 0.71A 2j5mA-4ehiA:
undetectable		 2j5mA-4ehiA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		5 / 9 LEU A 154
GLY A  12
ILE A  13
VAL A 150
ILE A 151
 None
 1.10A 2r5qA-4ehiA:
undetectable		 2r5qA-4ehiA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		5 / 9 LEU A 154
GLY A  12
ILE A  13
VAL A 150
ILE A 151
 None
 1.10A 2r5qC-4ehiA:
undetectable		 2r5qC-4ehiA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		5 / 11 PHE A 231
LEU A 350
ILE A 351
PHE A 226
LEU A 243
 None
 1.25A 3a9eB-4ehiA:
undetectable		 3a9eB-4ehiA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		5 / 11 PHE A 334
ILE A 322
ALA A 323
LEU A 305
ALA A 330
 None
 1.40A 3pcqB-4ehiA:
undetectable		 3pcqB-4ehiA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		5 / 6 LEU A 279
SER A 282
TYR A 283
ALA A 274
LEU A 309
 None
 1.10A 3ravA-4ehiA:
2.0		 3ravA-4ehiA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		4 / 6 LEU A 279
SER A 282
ALA A 274
LEU A 309
 None
 1.15A 3rd0A-4ehiA:
undetectable		 3rd0A-4ehiA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		4 / 6 LEU A 279
TYR A 283
ALA A 274
LEU A 309
 None
 0.85A 3rd0A-4ehiA:
undetectable		 3rd0A-4ehiA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		5 / 12 LEU A 395
TYR A 501
LEU A 398
MET A 402
THR A 503
 None
 1.46A 3thrA-4ehiA:
undetectable
3thrB-4ehiA:
undetectable
3thrC-4ehiA:
1.7
3thrD-4ehiA:
undetectable		 3thrA-4ehiA:
20.86
3thrB-4ehiA:
20.86
3thrC-4ehiA:
20.86
3thrD-4ehiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		4 / 5 VAL A 489
ASP A 486
PHE A 460
GLY A 481
 None
 1.15A 4xp6A-4ehiA:
undetectable		 4xp6A-4ehiA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		5 / 12 PHE A 231
LEU A 350
ILE A 351
PHE A 226
ILE A 246
 None
 1.13A 5m24A-4ehiA:
undetectable		 5m24A-4ehiA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		5 / 10 ALA A 310
LEU A 309
ILE A 321
ILE A 301
ILE A 264
 None
 1.05A 5mvmD-4ehiA:
2.7
5mvmE-4ehiA:
undetectable		 5mvmD-4ehiA:
9.33
5mvmE-4ehiA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Campylobacter
jejuni) 		5 / 10 PHE A 334
ILE A 322
ALA A 323
LEU A 305
ALA A 330
 None
 1.43A 5oy0b-4ehiA:
undetectable		 5oy0b-4ehiA:
14.29