SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ehj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 12 GLY A 214
GLY A 190
ALA A 187
LEU A 204
ASP A 347
 None
None
None
None
SO4  A 401 ( 4.6A)
 0.99A 1bx4A-4ehjA:
3.7		 1bx4A-4ehjA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 11 ASP A 347
VAL A 317
GLY A 216
ILE A 217
THR A 327
 SO4  A 401 ( 4.6A)
SO4  A 401 ( 4.5A)
None
None
None
 0.95A 1c6yA-4ehjA:
undetectable		 1c6yA-4ehjA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		4 / 4 LYS A 248
LEU A 205
ALA A 249
LEU A 211
 None
 1.31A 1f86B-4ehjA:
undetectable		 1f86B-4ehjA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		4 / 6 PHE A 141
PHE A 374
GLU A 175
VAL A 342
 None
 1.05A 1hk1A-4ehjA:
undetectable		 1hk1A-4ehjA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 10 GLU A 388
ALA A 155
PRO A 159
ALA A 130
TYR A 157
 None
 1.47A 1mskA-4ehjA:
undetectable		 1mskA-4ehjA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 12 LEU A 198
LEU A 201
ASN A 202
LEU A 204
LEU A 246
 None
 0.91A 1sqnB-4ehjA:
undetectable		 1sqnB-4ehjA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 12 LEU A 198
LEU A 201
ASN A 202
LEU A 204
LEU A 246
 None
 1.03A 1ya3C-4ehjA:
undetectable		 1ya3C-4ehjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 9 ILE A 188
GLY A 190
PRO A 259
VAL A 258
ILE A 256
 None
 1.06A 2r5qA-4ehjA:
undetectable		 2r5qA-4ehjA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 9 ILE A 188
GLY A 190
PRO A 259
VAL A 258
ILE A 256
 None
 1.06A 2r5qC-4ehjA:
undetectable		 2r5qC-4ehjA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 12 ILE A  47
ASP A 139
ILE A 106
LEU A  81
ILE A  41
 None
 0.87A 3clbC-4ehjA:
undetectable		 3clbC-4ehjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 9 ASP A 347
VAL A 317
GLY A 216
ILE A 217
THR A 327
 SO4  A 401 ( 4.6A)
SO4  A 401 ( 4.5A)
None
None
None
 1.05A 3el4B-4ehjA:
undetectable		 3el4B-4ehjA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 12 GLY A 346
GLY A 369
PHE A 374
LEU A 375
ALA A 367
 None
 1.09A 3kkzB-4ehjA:
3.6		 3kkzB-4ehjA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		4 / 7 GLY A 345
GLY A 190
PHE A 374
PHE A 141
 None
 0.93A 3ko0M-4ehjA:
undetectable
3ko0P-4ehjA:
undetectable		 3ko0M-4ehjA:
13.62
3ko0P-4ehjA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		4 / 7 GLY A 345
GLY A 191
PHE A 374
PHE A 141
 None
 0.86A 3ko0M-4ehjA:
undetectable
3ko0P-4ehjA:
undetectable		 3ko0M-4ehjA:
13.62
3ko0P-4ehjA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 12 PRO A 257
LEU A 302
LEU A 303
LEU A 330
ILE A 212
 None
 1.12A 4a7aB-4ehjA:
undetectable		 4a7aB-4ehjA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		4 / 4 VAL A 282
VAL A 264
ASN A 219
ILE A 222
 None
 1.20A 4cutA-4ehjA:
0.0		 4cutA-4ehjA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 12 LEU A 380
TYR A 152
ALA A 155
ASP A 139
MET A 138
 None
 1.47A 4j7xA-4ehjA:
4.0		 4j7xA-4ehjA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 12 LEU A  11
ILE A  47
GLY A 164
ALA A 163
ALA A 155
 None
 0.93A 4nkxC-4ehjA:
undetectable		 4nkxC-4ehjA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		5 / 12 LEU A  11
ILE A  47
GLY A 164
ALA A 163
ALA A 155
 None
 0.92A 4nkxD-4ehjA:
undetectable		 4nkxD-4ehjA:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		8 / 12 GLY A 191
GLY A 215
GLY A 216
LEU A 233
MET A 287
LEU A 289
GLY A 316
VAL A 317
 None
None
None
None
None
None
None
SO4  A 401 ( 4.5A)
 0.73A 4o33A-4ehjA:
47.1		 4o33A-4ehjA:
43.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		8 / 12 GLY A 191
GLY A 216
LEU A 233
PHE A 268
MET A 287
LEU A 289
GLY A 316
VAL A 317
 None
None
None
None
None
None
None
SO4  A 401 ( 4.5A)
 0.74A 4o33A-4ehjA:
47.1		 4o33A-4ehjA:
43.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		9 / 12 GLY A 191
GLY A 215
GLY A 216
LEU A 233
PHE A 268
MET A 287
LEU A 289
GLY A 316
VAL A 317
 None
None
None
None
None
None
None
None
SO4  A 401 ( 4.5A)
 0.71A 4o3fA-4ehjA:
23.8		 4o3fA-4ehjA:
43.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		6 / 12 GLY A 191
GLY A 215
PHE A 268
MET A 287
LEU A 289
VAL A 317
 None
None
None
None
None
SO4  A 401 ( 4.5A)
 1.16A 4o3fA-4ehjA:
23.8		 4o3fA-4ehjA:
43.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		3 / 3 THR A 143
ASN A 115
PHE A 114
 None
 0.55A 4pd9A-4ehjA:
undetectable		 4pd9A-4ehjA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		4 / 4 ILE A 217
ASN A 219
ILE A 291
VAL A 315
 None
 1.29A 4uy87-4ehjA:
undetectable		 4uy87-4ehjA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		3 / 3 GLU A 225
ILE A 298
ALA A 218
 None
 0.62A 4wnwB-4ehjA:
undetectable		 4wnwB-4ehjA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		4 / 5 VAL A 194
VAL A 213
GLY A 214
PHE A 221
 None
 1.08A 5d4nA-4ehjA:
undetectable
5d4nC-4ehjA:
undetectable		 5d4nA-4ehjA:
16.33
5d4nC-4ehjA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		4 / 5 GLY A 316
PRO A 293
GLN A 296
THR A 327
 None
 1.29A 5h5fA-4ehjA:
2.7		 5h5fA-4ehjA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 4ehj PHOSPHOGLYCERATE
KINASE
(Francisella
tularensis) 		4 / 8 ILE A 106
ILE A  37
ALA A  40
ILE A  41
 None
 0.47A 5mvmA-4ehjA:
undetectable
5mvmB-4ehjA:
undetectable		 5mvmA-4ehjA:
13.66
5mvmB-4ehjA:
13.66