SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 8 GLY A  86
HIS A  83
THR A  94
ILE A  90
 None
 0.76A 1gtnE-4ehtA:
undetectable
1gtnF-4ehtA:
undetectable		 1gtnE-4ehtA:
16.30
1gtnF-4ehtA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 7 GLY A  86
HIS A  83
THR A  94
ILE A  90
 None
 0.75A 1gtnF-4ehtA:
undetectable
1gtnG-4ehtA:
undetectable		 1gtnF-4ehtA:
16.30
1gtnG-4ehtA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 7 GLY A  86
HIS A  83
THR A  94
ILE A  90
 None
 0.74A 1gtnJ-4ehtA:
undetectable
1gtnK-4ehtA:
undetectable		 1gtnJ-4ehtA:
16.30
1gtnK-4ehtA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 8 LEU A  43
VAL A  60
GLY A   5
TYR A  47
 None
 0.96A 1jlbA-4ehtA:
2.9		 1jlbA-4ehtA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		5 / 11 SER A 198
ILE A 230
VAL A 206
VAL A 210
ILE A 204
 None
 1.37A 3rf4A-4ehtA:
undetectable
3rf4C-4ehtA:
undetectable		 3rf4A-4ehtA:
16.00
3rf4C-4ehtA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		5 / 11 ILE A 204
SER A 198
ILE A 230
VAL A 206
VAL A 210
 None
 1.37A 3rf4B-4ehtA:
undetectable
3rf4C-4ehtA:
undetectable		 3rf4B-4ehtA:
16.00
3rf4C-4ehtA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		5 / 12 TYR A  70
GLY A  15
GLY A   5
ILE A   8
ALA A  26
 None
 1.12A 4a6dA-4ehtA:
undetectable		 4a6dA-4ehtA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		6 / 12 GLY A 128
ALA A 127
ILE A 100
SER A 199
VAL A 197
ILE A  98
 None
SF4  A 301 ( 4.4A)
None
None
None
None
 1.46A 4ax8A-4ehtA:
undetectable		 4ax8A-4ehtA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		6 / 12 GLY A 128
ALA A 127
ILE A 100
SER A 199
VAL A 197
ILE A  98
 None
SF4  A 301 ( 4.4A)
None
None
None
None
 1.46A 4azvA-4ehtA:
undetectable		 4azvA-4ehtA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		5 / 12 ALA A  26
LEU A 242
GLY A   5
ALA A  73
TYR A  70
 None
CL  A 306 ( 4.7A)
None
None
None
 1.07A 4pclA-4ehtA:
undetectable		 4pclA-4ehtA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 5 GLY A  33
ALA A  12
GLY A  38
PRO A  39
 None
ADP  A 302 ( 3.3A)
None
None
 0.72A 4u9uA-4ehtA:
undetectable		 4u9uA-4ehtA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 5 GLY A  33
ALA A  12
GLY A  38
PRO A  39
 None
ADP  A 302 ( 3.3A)
None
None
 0.74A 4u9uB-4ehtA:
undetectable		 4u9uB-4ehtA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 5 GLY A 101
TYR A  65
SER A  10
ASP A 104
 ADP  A 302 (-3.6A)
None
ADP  A 302 (-4.2A)
None
 1.23A 4xueA-4ehtA:
undetectable		 4xueA-4ehtA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 7 LEU A 108
THR A  94
LEU A 110
THR A 243
 None
 0.91A 4z90A-4ehtA:
2.0
4z90B-4ehtA:
2.0
4z90C-4ehtA:
undetectable
4z90D-4ehtA:
undetectable
4z90E-4ehtA:
undetectable		 4z90A-4ehtA:
21.25
4z90B-4ehtA:
21.25
4z90C-4ehtA:
21.25
4z90D-4ehtA:
21.25
4z90E-4ehtA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		6 / 12 ALA A 249
THR A  63
GLY A  15
GLY A   5
ALA A  26
LEU A 242
 None
None
None
None
None
CL  A 306 ( 4.7A)
 1.32A 5c0oG-4ehtA:
undetectable		 5c0oG-4ehtA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		3 / 3 LYS A  59
LYS A 257
SER A 259
 None
 1.47A 5odiA-4ehtA:
undetectable		 5odiA-4ehtA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 7 PHE A  89
ALA A  84
GLY A  86
GLY A 244
 None
ACT  A 305 ( 3.3A)
None
None
 0.80A 5ybbB-4ehtA:
undetectable		 5ybbB-4ehtA:
17.99