SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ei8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 9 VAL A 366
LEU A 182
ILE A 170
ALA A 171
LEU A 362
 None
 1.12A 1eqgA-4ei8A:
undetectable		 1eqgA-4ei8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 11 VAL A 366
LEU A 182
ILE A 170
ALA A 171
LEU A 362
 None
 1.12A 1eqgB-4ei8A:
undetectable		 1eqgB-4ei8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		4 / 7 PHE A 109
LEU A  52
GLY A  27
ILE A 115
 None
 0.74A 1p2yA-4ei8A:
undetectable		 1p2yA-4ei8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 11 PHE A  94
VAL A  89
GLY A  22
ILE A  74
LEU A  76
 None
 0.98A 1z11A-4ei8A:
undetectable		 1z11A-4ei8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 11 PHE A  94
VAL A  89
GLY A  22
ILE A  74
LEU A  76
 None
 0.99A 1z11B-4ei8A:
undetectable		 1z11B-4ei8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 10 PHE A  94
VAL A  89
GLY A  22
ILE A  74
LEU A  76
 None
 0.97A 1z11C-4ei8A:
undetectable		 1z11C-4ei8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 10 PHE A  94
VAL A  89
GLY A  22
ILE A  74
LEU A  76
 None
 0.94A 1z11D-4ei8A:
undetectable		 1z11D-4ei8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		4 / 7 LEU A  23
GLY A 120
THR A 149
ILE A 212
 None
 0.85A 2bdmA-4ei8A:
undetectable		 2bdmA-4ei8A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 12 LEU A 277
ASN A 275
GLY A 280
LEU A 273
LEU A 254
 None
 0.90A 2egvA-4ei8A:
undetectable		 2egvA-4ei8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 12 LEU A 277
ASN A 275
GLY A 280
LEU A 273
LEU A 254
 None
 0.94A 2egvB-4ei8A:
undetectable		 2egvB-4ei8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 12 LEU A 216
LEU A 148
LEU A 362
PRO A 363
VAL A 366
 None
 1.07A 2pnjA-4ei8A:
2.1		 2pnjA-4ei8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		4 / 8 PHE A  60
ILE A  63
GLY A  27
GLY A  26
 None
 0.84A 2qx4A-4ei8A:
4.5
2qx4B-4ei8A:
6.0		 2qx4A-4ei8A:
20.78
2qx4B-4ei8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		3 / 3 ASN A 202
ASP A  59
GLN A  58
 None
 0.72A 3eeyC-4ei8A:
4.8		 3eeyC-4ei8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		3 / 3 ASN A 202
ASP A  59
GLN A  58
 None
 0.72A 3eeyD-4ei8A:
4.9		 3eeyD-4ei8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		3 / 3 ASN A 202
ASP A  59
GLN A  58
 None
 0.73A 3eeyE-4ei8A:
4.5		 3eeyE-4ei8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 12 ALA A 215
ILE A 243
LEU A 249
THR A 118
VAL A 181
 None
 1.05A 3rukA-4ei8A:
undetectable		 3rukA-4ei8A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		4 / 6 PHE A 144
PHE A 114
ASN A 244
PHE A 177
 None
 1.12A 3t3sB-4ei8A:
undetectable		 3t3sB-4ei8A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		4 / 7 VAL A 366
LEU A 150
LEU A 121
ILE A 180
 None
 0.98A 3u5kB-4ei8A:
undetectable		 3u5kB-4ei8A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		4 / 8 VAL A 366
LEU A 150
LEU A 121
ILE A 180
 None
 0.89A 3u5kD-4ei8A:
undetectable		 3u5kD-4ei8A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 10 THR A 223
SER A  15
LEU A 251
VAL A 181
VAL A 356
 None
 1.49A 3u9fE-4ei8A:
undetectable		 3u9fE-4ei8A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 9 ALA A  31
GLY A  27
LEU A  21
ASN A  54
ILE A 117
 None
 1.47A 3wdmA-4ei8A:
3.6		 3wdmA-4ei8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		4 / 5 VAL A 366
LEU A 150
LEU A 121
ILE A 180
 None
 0.95A 4a9jB-4ei8A:
undetectable		 4a9jB-4ei8A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 10 ILE A 183
LEU A 282
THR A 149
GLY A 120
GLY A  27
 None
 1.27A 4bwlC-4ei8A:
2.8		 4bwlC-4ei8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		4 / 7 SER A 165
GLU A 372
ILE A 373
ASN A 162
 None
 1.02A 4d33B-4ei8A:
undetectable		 4d33B-4ei8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		4 / 8 SER A 165
GLU A 372
ILE A 373
ASN A 162
 None
 0.98A 4d39A-4ei8A:
undetectable		 4d39A-4ei8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 11 SER A 208
THR A 205
ALA A  35
THR A 149
GLY A 120
 None
 1.17A 4zjoD-4ei8A:
undetectable		 4zjoD-4ei8A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		4 / 5 ILE A  74
GLY A  22
ILE A 101
LEU A  52
 None
 0.82A 5dzki-4ei8A:
1.4
5dzkj-4ei8A:
1.5
5dzkx-4ei8A:
undetectable		 5dzki-4ei8A:
20.62
5dzkj-4ei8A:
20.62
5dzkx-4ei8A:
1.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		4 / 5 ILE A  74
GLY A  22
ILE A 101
LEU A  52
 None
 0.93A 5dzkd-4ei8A:
undetectable
5dzkk-4ei8A:
1.5
5dzky-4ei8A:
undetectable		 5dzkd-4ei8A:
19.23
5dzkk-4ei8A:
20.62
5dzky-4ei8A:
1.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		4 / 4 LEU A 290
LEU A 360
SER A 296
ALA A 358
 None
 1.10A 5uunA-4ei8A:
undetectable		 5uunA-4ei8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 12 ASP A 111
PHE A 114
LEU A 249
ILE A  30
ALA A  31
 None
 1.19A 5vc0A-4ei8A:
undetectable		 5vc0A-4ei8A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4ei8 PLASMID REPLICATION
PROTEIN REPX
(Bacillus
cereus) 		5 / 12 LEU A 148
LEU A 130
ALA A 133
LEU A 146
GLY A  19
 None
 0.88A 6b0cD-4ei8A:
20.7		 6b0cD-4ei8A:
12.47