SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		4 / 5 LEU A  25
ASP A  24
GLY A 454
VAL A  30
 None
 0.91A 2aojA-4eipA:
undetectable		 2aojA-4eipA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 10 THR A 311
GLY A 295
THR A 294
ALA A 298
VAL A 346
 None
FAD  A 602 (-3.4A)
None
None
None
 1.28A 2coiA-4eipA:
undetectable
2coiB-4eipA:
undetectable		 2coiA-4eipA:
22.62
2coiB-4eipA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 10 VAL A 346
THR A 311
GLY A 295
THR A 294
ALA A 298
 None
None
FAD  A 602 (-3.4A)
None
None
 1.26A 2coiA-4eipA:
undetectable
2coiB-4eipA:
undetectable		 2coiA-4eipA:
22.62
2coiB-4eipA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 11 THR A 311
GLY A 295
THR A 294
ALA A 298
VAL A 346
 None
FAD  A 602 (-3.4A)
None
None
None
 1.26A 2cojA-4eipA:
undetectable
2cojB-4eipA:
undetectable		 2cojA-4eipA:
22.62
2cojB-4eipA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 9 VAL A 346
THR A 311
GLY A 295
THR A 294
ALA A 298
 None
None
FAD  A 602 (-3.4A)
None
None
 1.28A 2cojA-4eipA:
undetectable
2cojB-4eipA:
undetectable		 2cojA-4eipA:
22.62
2cojB-4eipA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		3 / 3 THR A 447
PRO A 437
TYR A 494
 None
 0.95A 2dxrA-4eipA:
undetectable		 2dxrA-4eipA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		4 / 4 ASP A 172
ASP A  36
ASP A 296
GLY A  18
 None
FAD  A 602 (-2.7A)
FAD  A 602 (-3.3A)
None
 1.19A 2igtC-4eipA:
3.1		 2igtC-4eipA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 12 GLY A  13
GLY A  15
ALA A  20
LEU A  21
ALA A  37
 FAD  A 602 (-3.1A)
FAD  A 602 (-3.7A)
None
None
FAD  A 602 (-4.0A)
 0.86A 2yvlA-4eipA:
3.0		 2yvlA-4eipA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 12 GLY A  13
GLY A  15
ALA A  20
LEU A  21
ALA A  37
 FAD  A 602 (-3.1A)
FAD  A 602 (-3.7A)
None
None
FAD  A 602 (-4.0A)
 0.87A 2yvlB-4eipA:
3.0		 2yvlB-4eipA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 12 GLY A  13
GLY A  15
ALA A  20
LEU A  21
ALA A  37
 FAD  A 602 (-3.1A)
FAD  A 602 (-3.7A)
None
None
FAD  A 602 (-4.0A)
 0.87A 2yvlD-4eipA:
3.0		 2yvlD-4eipA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 12 TYR A 339
GLY A  18
GLY A  14
ALA A 121
LEU A 124
 None
None
FAD  A 602 ( 4.9A)
None
None
 1.04A 2zulA-4eipA:
undetectable		 2zulA-4eipA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 12 TYR A 339
GLY A  18
GLY A  15
ALA A 121
LEU A 124
 None
None
FAD  A 602 (-3.7A)
None
None
 1.08A 2zulA-4eipA:
undetectable		 2zulA-4eipA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		4 / 6 ARG A 166
PRO A 479
GLY A 329
TRP A 330
 None
 1.30A 3aqiB-4eipA:
undetectable		 3aqiB-4eipA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 12 TYR A 339
GLY A  18
GLY A  14
ALA A 121
LEU A 124
 None
None
FAD  A 602 ( 4.9A)
None
None
 1.01A 3dmhA-4eipA:
undetectable		 3dmhA-4eipA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 12 TYR A 339
GLY A  18
GLY A  15
ALA A 121
LEU A 124
 None
None
FAD  A 602 (-3.7A)
None
None
 1.06A 3dmhA-4eipA:
undetectable		 3dmhA-4eipA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 12 ILE A  11
ALA A  20
LEU A  21
HIS A 299
ILE A  67
 None
 0.90A 3ozwB-4eipA:
2.3		 3ozwB-4eipA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 11 VAL A  86
TYR A 238
LEU A 229
GLY A 210
ALA A 213
 None
 1.24A 3pghB-4eipA:
undetectable		 3pghB-4eipA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 12 SER A  54
GLY A 312
GLY A  18
ALA A  20
GLY A 314
 None
 1.17A 3tegA-4eipA:
undetectable		 3tegA-4eipA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		3 / 3 TYR A 408
HIS A 506
ARG A 502
 None
 0.88A 4e7bC-4eipA:
undetectable		 4e7bC-4eipA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		4 / 5 VAL A 525
ARG A 502
GLU A 342
LEU A 335
 None
 1.37A 4hojA-4eipA:
2.1		 4hojA-4eipA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		3 / 3 ASP A 318
GLY A 320
ASP A  24
 None
 0.69A 4xdtA-4eipA:
0.6		 4xdtA-4eipA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		4 / 5 GLY A 295
SER A 315
ARG A 343
GLY A 314
 FAD  A 602 (-3.4A)
None
None
None
 1.03A 5kprA-4eipA:
undetectable		 5kprA-4eipA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 9 ILE A 313
GLY A 312
GLY A 295
LEU A 124
ALA A  20
 None
None
FAD  A 602 (-3.4A)
None
None
 0.82A 5o96A-4eipA:
undetectable
5o96B-4eipA:
2.8		 5o96A-4eipA:
20.45
5o96B-4eipA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		5 / 12 ASP A 504
ALA A 325
PHE A 455
LEU A 521
LEU A 500
 None
 1.16A 5tudA-4eipA:
undetectable		 5tudA-4eipA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		4 / 5 VAL A 242
HIS A  44
LEU A 229
ASP A 273
 None
 1.22A 5vcvA-4eipA:
undetectable		 5vcvA-4eipA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		4 / 4 VAL A  17
GLY A 295
ASP A 296
ASP A 172
 FAD  A 602 (-4.0A)
FAD  A 602 (-3.4A)
FAD  A 602 (-3.3A)
None
 1.05A 6cjkC-4eipA:
undetectable		 6cjkC-4eipA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4eip PUTATIVE
FAD-MONOOXYGENASE
(Lechevalieria
aerocolonigenes) 		3 / 3 ASP A  24
LEU A  25
ARG A 328
 None
 0.81A 7dfrA-4eipA:
undetectable		 7dfrA-4eipA:
15.71