SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ej0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		5 / 10 SER A 217
VAL A 218
GLY A 171
PRO A 172
GLU A  22
 None
 1.47A 1equA-4ej0A:
16.1		 1equA-4ej0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		4 / 8 GLN A 190
ASN A 189
LEU A 326
SER A 182
 None
 1.24A 1hk2A-4ej0A:
undetectable		 1hk2A-4ej0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		5 / 12 LEU A 199
LEU A 278
GLY A 277
VAL A 256
ALA A 253
 None
 1.12A 2kceB-4ej0A:
undetectable		 2kceB-4ej0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		4 / 8 PHE A  11
GLY A  13
VAL A  17
LEU A  43
 NAP  A 401 (-4.8A)
None
None
None
 1.04A 3bgdB-4ej0A:
4.6		 3bgdB-4ej0A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		3 / 3 ASP A 214
ASP A 299
ASP A 220
 None
 0.78A 3douA-4ej0A:
5.9		 3douA-4ej0A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		5 / 12 THR A 242
VAL A 319
TYR A 322
SER A 182
VAL A 255
 None
 1.11A 3frqA-4ej0A:
undetectable		 3frqA-4ej0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		5 / 12 THR A 242
VAL A 319
TYR A 322
SER A 182
VAL A 255
 None
 0.93A 3frqB-4ej0A:
undetectable		 3frqB-4ej0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		4 / 5 ILE A 119
PRO A 135
LYS A 143
GLY A 140
 None
None
NAP  A 401 (-3.0A)
None
 1.15A 3tkdB-4ej0A:
undetectable		 3tkdB-4ej0A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		4 / 5 ILE A 119
PRO A 135
LYS A 143
GLY A 140
 None
None
NAP  A 401 (-3.0A)
None
 1.14A 3tkdA-4ej0A:
undetectable		 3tkdA-4ej0A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		4 / 6 GLY A 241
ASP A 220
ASN A 225
GLU A  75
 None
 1.03A 3vywC-4ej0A:
4.2		 3vywC-4ej0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		5 / 12 SER A  97
VAL A 100
PHE A  66
ILE A   4
PHE A  61
 None
 1.37A 4c49C-4ej0A:
undetectable		 4c49C-4ej0A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		3 / 3 TYR A 292
PHE A 215
ARG A 213
 None
 1.01A 4g19D-4ej0A:
undetectable		 4g19D-4ej0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		3 / 3 ARG A 151
GLU A 131
ARG A 165
 None
 0.96A 4mwvA-4ej0A:
undetectable		 4mwvA-4ej0A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		5 / 9 ALA A  30
ILE A  12
GLY A  10
ALA A   9
ILE A  48
 None
NAP  A 401 (-3.9A)
NAP  A 401 (-3.3A)
None
None
 0.98A 4r21B-4ej0A:
undetectable		 4r21B-4ej0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		5 / 11 ILE A   4
PHE A  66
ILE A  28
VAL A  58
LEU A  52
 None
 1.33A 5jkwA-4ej0A:
undetectable		 5jkwA-4ej0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		3 / 3 SER A 116
ALA A 117
THR A 296
 NAP  A 401 (-3.3A)
None
None
 0.35A 5n0xB-4ej0A:
undetectable		 5n0xB-4ej0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E
(Burkholderia
thailandensis) 		4 / 7 ARG A 165
ALA A 114
ILE A 119
ALA A 118
 None
NAP  A 401 (-3.5A)
None
None
 0.77A 6ma7A-4ej0A:
undetectable		 6ma7A-4ej0A:
12.84