SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ej4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 4ej4 DELTA-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		4 / 5 VAL A 272
ILE A 226
TYR A 147
MET A 236
 None
 1.42A 3gvuA-4ej4A:
undetectable		 3gvuA-4ej4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4ej4 DELTA-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		5 / 9 ILE A1058
ALA A1042
LEU A1046
LEU A1066
ALA A1063
 None
 1.10A 3ozvB-4ej4A:
undetectable		 3ozvB-4ej4A:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 4ej4 DELTA-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		5 / 12 ASP A 128
TYR A 129
ILE A 136
TRP A 274
TYR A 308
 EJ4  A 500 (-3.0A)
EJ4  A 500 (-4.4A)
None
EJ4  A 500 (-4.5A)
EJ4  A 500 (-3.8A)
 0.81A 3rzeA-4ej4A:
32.7		 3rzeA-4ej4A:
52.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4ej4 DELTA-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Mus
musculus;
Escherichia
virus
T4) 		5 / 10 ILE A 183
GLY A 180
GLY A 178
PHE A 202
MET A 186
 None
 0.97A 4fakA-4ej4A:
undetectable		 4fakA-4ej4A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4ej4 DELTA-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Mus
musculus;
Escherichia
virus
T4) 		4 / 7 THR A1026
TYR A1018
GLU A1011
HIS A1031
 None
 1.11A 5ecnA-4ej4A:
undetectable		 5ecnA-4ej4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4ej4 DELTA-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Mus
musculus;
Escherichia
virus
T4) 		4 / 5 ASP A 128
ILE A 136
PHE A 270
TYR A 308
 EJ4  A 500 (-3.0A)
None
None
EJ4  A 500 (-3.8A)
 0.63A 6a93B-4ej4A:
27.9		 6a93B-4ej4A:
25.53