SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ej6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 9 ILE A 220
LEU A 281
ARG A 279
VAL A 234
ALA A 164
None
None
EDO  A 409 ( 3.7A)
None
None
1.21A 1e7aA-4ej6A:
undetectable
1e7aA-4ej6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 GLU A 202
LEU A 199
ILE A 165
GLY A 172
LEU A 174
EDO  A 410 (-3.2A)
EDO  A 410 (-4.1A)
None
CL  A 419 (-3.9A)
None
1.26A 1g50B-4ej6A:
undetectable
1g50B-4ej6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 11 GLU A 202
LEU A 199
ILE A 165
GLY A 172
LEU A 174
EDO  A 410 (-3.2A)
EDO  A 410 (-4.1A)
None
CL  A 419 (-3.9A)
None
1.26A 1g50C-4ej6A:
undetectable
1g50C-4ej6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
4 / 8 GLY A 254
ARG A 279
LEU A 281
VAL A 234
None
EDO  A 409 ( 3.7A)
None
None
1.19A 1gsfA-4ej6A:
undetectable
1gsfA-4ej6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
4 / 8 GLY A 254
ARG A 279
LEU A 281
VAL A 234
None
EDO  A 409 ( 3.7A)
None
None
1.19A 1gsfB-4ej6A:
undetectable
1gsfB-4ej6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
4 / 8 GLY A 254
ARG A 279
LEU A 281
VAL A 234
None
EDO  A 409 ( 3.7A)
None
None
1.19A 1gsfD-4ej6A:
undetectable
1gsfD-4ej6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 GLY A 239
GLU A 236
ILE A 171
ILE A 259
LEU A 260
None
None
CL  A 419 ( 4.8A)
None
None
1.06A 1kyvA-4ej6A:
2.8
1kyvE-4ej6A:
2.8
1kyvA-4ej6A:
19.34
1kyvE-4ej6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 ILE A 259
LEU A 260
GLY A 239
GLU A 236
ILE A 171
None
None
None
None
CL  A 419 ( 4.8A)
1.04A 1kyvB-4ej6A:
3.0
1kyvC-4ej6A:
2.9
1kyvB-4ej6A:
19.34
1kyvC-4ej6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 ILE A 259
LEU A 260
GLY A 239
GLU A 236
ILE A 171
None
None
None
None
CL  A 419 ( 4.8A)
1.03A 1kyvC-4ej6A:
2.9
1kyvD-4ej6A:
3.0
1kyvC-4ej6A:
19.34
1kyvD-4ej6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 ILE A 259
LEU A 260
GLY A 239
GLU A 236
ILE A 171
None
None
None
None
CL  A 419 ( 4.8A)
1.05A 1kyvD-4ej6A:
2.9
1kyvE-4ej6A:
2.8
1kyvD-4ej6A:
19.34
1kyvE-4ej6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
4 / 8 ASP A  40
LEU A  43
HIS A  58
HIS A 111
None
1.03A 2q0iA-4ej6A:
undetectable
2q0iA-4ej6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 GLU A 202
LEU A 199
ILE A 165
GLY A 172
LEU A 174
EDO  A 410 (-3.2A)
EDO  A 410 (-4.1A)
None
CL  A 419 (-3.9A)
None
1.18A 2yjaB-4ej6A:
undetectable
2yjaB-4ej6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 LEU A 199
GLY A  35
ILE A 171
LEU A 174
ILE A 311
EDO  A 410 (-4.1A)
None
CL  A 419 ( 4.8A)
None
None
1.02A 3adxB-4ej6A:
undetectable
3adxB-4ej6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 GLY A 109
GLY A 115
ASN A  85
ALA A 107
ASP A  40
None
1.09A 3ckkA-4ej6A:
5.8
3ckkA-4ej6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
4 / 8 ALA A 107
ILE A  86
ASN A  85
PRO A 123
None
0.74A 3fxrA-4ej6A:
undetectable
3fxrA-4ej6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
3 / 3 ASN A 289
ASP A  83
ASN A  85
None
EDO  A 401 (-3.8A)
None
0.64A 4agaA-4ej6A:
undetectable
4agaA-4ej6A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 VAL A  31
LEU A 134
VAL A 137
GLY A 139
ALA A 140
None
1.01A 4coxA-4ej6A:
undetectable
4coxA-4ej6A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 VAL A  31
LEU A 134
VAL A 137
GLY A 139
ALA A 140
None
1.01A 4coxB-4ej6A:
undetectable
4coxB-4ej6A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 VAL A  31
LEU A 134
VAL A 137
GLY A 139
ALA A 140
None
1.00A 4coxD-4ej6A:
undetectable
4coxD-4ej6A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 GLY A 172
VAL A 176
THR A 175
LEU A 174
VAL A 333
CL  A 419 (-3.9A)
None
None
None
None
1.11A 4f84A-4ej6A:
6.8
4f84A-4ej6A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 LEU A  43
ILE A 324
GLU A 143
GLY A  57
GLY A 114
None
1.19A 4hfpB-4ej6A:
undetectable
4hfpB-4ej6A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 LEU A  43
ILE A 324
GLU A 143
ALA A 107
GLY A 115
None
1.14A 4hfpD-4ej6A:
undetectable
4hfpD-4ej6A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 10 THR A 206
ILE A 235
VAL A 152
ALA A 184
ILE A 157
None
1.06A 4lbgA-4ej6A:
4.2
4lbgA-4ej6A:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 9 THR A 206
ILE A 235
VAL A 152
ALA A 184
ILE A 157
None
1.05A 4lbgB-4ej6A:
3.9
4lbgB-4ej6A:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
4 / 7 LEU A 149
LEU A 181
ILE A 165
VAL A 187
None
EDO  A 406 ( 4.4A)
None
None
0.84A 4ojbA-4ej6A:
undetectable
4ojbA-4ej6A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 VAL A  31
LEU A 134
VAL A 137
GLY A 139
ALA A 140
None
1.05A 4otyA-4ej6A:
undetectable
4otyA-4ej6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 VAL A  31
LEU A 134
VAL A 137
GLY A 139
ALA A 140
None
1.05A 4otyB-4ej6A:
undetectable
4otyB-4ej6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 VAL A  31
LEU A 134
VAL A 137
GLY A 139
ALA A 140
None
0.99A 4rrwC-4ej6A:
undetectable
4rrwC-4ej6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 VAL A  31
LEU A 134
VAL A 137
GLY A 139
ALA A 140
None
0.96A 4rrwD-4ej6A:
undetectable
4rrwD-4ej6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 VAL A  31
LEU A 134
VAL A 137
GLY A 139
ALA A 140
None
0.99A 4rrzC-4ej6A:
undetectable
4rrzC-4ej6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 12 VAL A  31
LEU A 134
VAL A 137
GLY A 139
ALA A 140
None
0.96A 4rrzD-4ej6A:
undetectable
4rrzD-4ej6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
4 / 5 THR A  55
GLY A  57
HIS A 111
ASP A 113
None
None
None
EDO  A 408 (-3.3A)
1.00A 5c0oH-4ej6A:
8.2
5c0oH-4ej6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 11 GLU A 202
LEU A 199
ILE A 165
GLY A 172
LEU A 174
EDO  A 410 (-3.2A)
EDO  A 410 (-4.1A)
None
CL  A 419 (-3.9A)
None
1.15A 5dxbB-4ej6A:
undetectable
5dxbB-4ej6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
3 / 3 GLY A  89
CYH A  94
CYH A  91
ZN  A 418 ( 4.8A)
ZN  A 418 (-2.3A)
ZN  A 418 (-2.3A)
0.96A 5inzB-4ej6A:
undetectable
5inzB-4ej6A:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 11 LEU A 166
GLY A 172
SER A 247
LEU A 250
VAL A 163
None
CL  A 419 (-3.9A)
None
None
None
1.01A 5o96A-4ej6A:
2.8
5o96B-4ej6A:
3.3
5o96A-4ej6A:
22.10
5o96B-4ej6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti)
5 / 11 LEU A 166
GLY A 167
GLY A 172
LEU A 250
VAL A 163
None
EDO  A 407 (-3.8A)
CL  A 419 (-3.9A)
None
None
0.93A 5o96G-4ej6A:
2.7
5o96G-4ej6A:
22.10