SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ejs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 12 ALA C 243
TYR B  57
ASP B 107
SER B 108
THR B  76
 None
 1.23A 1dy4A-4ejsC:
undetectable		 1dy4A-4ejsC:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 158
LEU B  26
LYS B 209
LEU B 121
 None
 0.84A 1hk2A-4ejsB:
undetectable		 1hk2A-4ejsB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		4 / 8 SER C 134
THR B  76
PHE C 170
ASN C 167
 None
 1.09A 1lhvA-4ejsC:
undetectable		 1lhvA-4ejsC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4ejs ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		4 / 7 VAL C 158
VAL C 129
LEU C 130
LEU C 154
 None
 0.78A 1pthA-4ejsC:
0.0		 1pthA-4ejsC:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4ejs ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		4 / 7 VAL C 158
VAL C 129
LEU C 130
LEU C 154
 None
 0.77A 1pthB-4ejsC:
undetectable		 1pthB-4ejsC:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ejs ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 9 PHE C 108
VAL C 158
LEU C 161
PHE C 112
LEU C 126
 None
 1.32A 1wrkA-4ejsC:
undetectable
1wrkB-4ejsC:
undetectable		 1wrkA-4ejsC:
15.13
1wrkB-4ejsC:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ejs ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 9 VAL C 158
LEU C 161
PHE C 112
PHE C 207
LEU C 126
 None
 1.08A 1wrkA-4ejsC:
undetectable
1wrkB-4ejsC:
undetectable		 1wrkA-4ejsC:
15.13
1wrkB-4ejsC:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 121
ILE B 124
PHE B  80
LEU B  83
LEU B 109
 None
 1.00A 1xdkF-4ejsB:
undetectable		 1xdkF-4ejsB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 4 LEU B  38
PRO B   8
ILE B  15
LEU B  16
 None
 1.07A 1ya4B-4ejsB:
undetectable		 1ya4B-4ejsB:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 5 ILE B  39
ILE B 124
ILE B  55
LEU B 161
 None
 0.87A 1zgyA-4ejsB:
undetectable		 1zgyA-4ejsB:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		3 / 3 ASN B 110
ILE B  58
MET B 131
 None
 0.72A 2h42C-4ejsB:
undetectable		 2h42C-4ejsB:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4ejs ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 12 LEU C  79
ILE C 145
LEU C  18
ILE C 147
PRO C  42
 None
 1.16A 2ygpA-4ejsC:
undetectable		 2ygpA-4ejsC:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		4 / 6 THR C  35
GLN C  37
ILE B 193
SER C 187
 None
 1.29A 3peoG-4ejsC:
undetectable		 3peoG-4ejsC:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 12 ALA C 243
ASN C 167
ILE C 171
LEU C 175
VAL B  63
 None
 1.05A 3rukA-4ejsC:
undetectable		 3rukA-4ejsC:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 197
VAL B 173
GLU C 256
LEU B 179
THR B 176
 None
 1.09A 3tbgA-4ejsB:
undetectable		 3tbgA-4ejsB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4ejs ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		3 / 3 PHE C 207
LYS C 214
SER C 215
 None
 1.02A 3tyeB-4ejsC:
undetectable		 3tyeB-4ejsC:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 SER B  30
PHE C 212
LYS C 209
 None
 0.89A 3u88A-4ejsB:
undetectable		 3u88A-4ejsB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 THR C 172
ARG C 176
PHE B  60
SER B  59
 None
 1.49A 4o4dA-4ejsC:
undetectable		 4o4dA-4ejsC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 204
LEU B  12
ILE B  15
LEU B  16
PHE B  42
 None
 0.85A 4odrA-4ejsB:
undetectable
4odrB-4ejsB:
undetectable		 4odrA-4ejsB:
17.52
4odrB-4ejsB:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 6 GLU B  61
PHE B  60
TYR B 135
HIS B 136
 None
 0.98A 4uciA-4ejsB:
undetectable		 4uciA-4ejsB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 7 GLU B  61
PHE B  60
TYR B 135
HIS B 136
 None
 0.99A 4uciB-4ejsB:
undetectable		 4uciB-4ejsB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		3 / 3 SER B 108
ALA B 133
VAL B 132
 None
 0.54A 4x1iA-4ejsB:
undetectable		 4x1iA-4ejsB:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4ejs ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 11 LEU C  79
LEU C  61
LEU C  96
LEU C  93
ILE C  98
 None
 1.06A 4zowA-4ejsC:
1.0		 4zowA-4ejsC:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		3 / 3 SER B 108
ALA B 133
VAL B 132
 None
 0.52A 5eypA-4ejsB:
undetectable		 5eypA-4ejsB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 4ejs ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 12 ALA C 131
LEU C 126
ILE C 148
LEU C 154
LEU C 106
 None
 0.97A 5toaA-4ejsC:
undetectable		 5toaA-4ejsC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4ejs ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 12 LEU C 252
THR C 247
ASN C  30
VAL C 180
THR C  52
 None
 1.48A 5v1tA-4ejsC:
undetectable		 5v1tA-4ejsC:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4ejs ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 9 ASN C 186
SER C  38
PHE C 228
SER C 235
GLY C 234
 None
 1.32A 6awpA-4ejsC:
undetectable		 6awpA-4ejsC:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 4ejs ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 168
LEU B  26
SER B 215
LEU B 158
THR B 159
 None
 1.18A 6b52A-4ejsB:
undetectable		 6b52A-4ejsB:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4ejs ELONGATOR COMPLEX
PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 12 PRO C  99
ILE C  98
HIS C  53
VAL C  50
HIS C  76
 None
 1.28A 6j21A-4ejsC:
undetectable		 6j21A-4ejsC:
20.91