SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		5 / 12 ASP A 346
LEU A 144
THR A 150
ARG A 353
GLY A  91
 None
 1.34A 1ia0B-4ekuA:
undetectable		 1ia0B-4ekuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		4 / 6 ASP A 278
LEU A 279
VAL A 280
ILE A 281
 None
 0.83A 1s9qA-4ekuA:
undetectable		 1s9qA-4ekuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		5 / 12 ASP A 346
LEU A 144
THR A 150
ARG A 353
GLY A  91
 None
 1.34A 1tubB-4ekuA:
undetectable		 1tubB-4ekuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		5 / 12 LEU A 299
LEU A 279
ILE A 286
ILE A 348
LEU A 320
 None
 1.06A 2bdmA-4ekuA:
undetectable		 2bdmA-4ekuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		5 / 11 LEU A 176
ILE A 231
PHE A 227
LEU A 210
ASP A 211
 None
 1.22A 2q6hA-4ekuA:
undetectable		 2q6hA-4ekuA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		5 / 11 LEU A 176
ILE A 231
PHE A 227
LEU A 210
ASP A 211
 None
 1.19A 2qeiA-4ekuA:
undetectable		 2qeiA-4ekuA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		5 / 11 SER A  73
ILE A  70
PHE A  45
VAL A  43
ILE A  80
 None
 1.29A 3rf4A-4ekuA:
undetectable
3rf4C-4ekuA:
undetectable		 3rf4A-4ekuA:
13.98
3rf4C-4ekuA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		5 / 11 ILE A  80
SER A  73
ILE A  70
PHE A  45
VAL A  43
 None
 1.34A 3rf4A-4ekuA:
undetectable
3rf4B-4ekuA:
undetectable		 3rf4A-4ekuA:
13.98
3rf4B-4ekuA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		5 / 11 ILE A  80
SER A  73
ILE A  70
PHE A  45
VAL A  43
 None
 1.33A 3rf4B-4ekuA:
undetectable
3rf4C-4ekuA:
undetectable		 3rf4B-4ekuA:
13.98
3rf4C-4ekuA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		3 / 3 ARG A 228
LYS A 229
LYS A 225
 None
 1.29A 4k50A-4ekuA:
undetectable		 4k50A-4ekuA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		3 / 3 ARG A 228
LYS A 229
LYS A 225
 None
 1.33A 4k50I-4ekuA:
undetectable		 4k50I-4ekuA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		4 / 5 TYR A 129
GLU A 119
LEU A  41
GLN A 115
 None
 1.32A 4qztB-4ekuA:
undetectable		 4qztB-4ekuA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		4 / 5 GLU A 126
GLU A 119
TYR A 118
GLU A 101
 None
 1.49A 4r87E-4ekuA:
undetectable		 4r87E-4ekuA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		5 / 10 GLY A 282
GLU A 263
LEU A 354
ASP A 346
ALA A 345
 None
 1.31A 4wnuD-4ekuA:
undetectable		 4wnuD-4ekuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		3 / 3 THR A 110
ASP A 116
GLU A 119
 None
 0.86A 5fa8A-4ekuA:
undetectable		 5fa8A-4ekuA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		4 / 7 GLN A 355
GLY A 285
ILE A 348
TYR A 265
 None
 1.17A 5vlmC-4ekuA:
undetectable		 5vlmC-4ekuA:
19.05