SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4el1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A 369
VAL A 421
TRP A 407
 None
 0.82A 1w5uA-4el1A:
undetectable
1w5uB-4el1A:
undetectable		 1w5uA-4el1A:
3.37
1w5uB-4el1A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A 421
TRP A 407
VAL A 369
 None
 0.92A 2izqC-4el1A:
undetectable
2izqD-4el1A:
undetectable		 2izqC-4el1A:
3.37
2izqD-4el1A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 11 PHE A 249
PHE A 275
VAL A 237
ILE A 238
PRO A 235
 None
 1.39A 2vcdA-4el1A:
undetectable		 2vcdA-4el1A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 12 LEU A 403
LEU A 443
ILE A 422
TYR A 414
PHE A 466
 None
 1.14A 2weyA-4el1A:
undetectable		 2weyA-4el1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		4 / 6 ARG A 132
ASP A 180
ILE A 179
GLN A 233
 None
 1.32A 2ya7C-4el1A:
undetectable		 2ya7C-4el1A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 9 LEU A 470
PHE A 469
SER A 472
ILE A 455
ALA A 448
 None
 1.26A 3mdtA-4el1A:
undetectable		 3mdtA-4el1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 10 ALA A 156
VAL A 204
GLY A 159
ILE A 186
VAL A 150
 None
 1.05A 4j5jB-4el1A:
undetectable		 4j5jB-4el1A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A 388
ALA A 448
PHE A 445
 None
 0.73A 4z4iA-4el1A:
undetectable		 4z4iA-4el1A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A 388
ALA A 448
PHE A 445
 None
 0.70A 5js1A-4el1A:
undetectable		 5js1A-4el1A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 12 GLN A  93
ALA A  91
VAL A  46
ASP A 109
PHE A 105
 None
 1.31A 5vlmG-4el1A:
undetectable		 5vlmG-4el1A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		4 / 6 PHE A 377
LEU A 372
ALA A 381
GLN A 358
 None
 1.04A 6b89B-4el1A:
undetectable		 6b89B-4el1A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		4 / 8 THR A 462
TYR A 457
TRP A 407
LEU A 410
 None
 1.35A 6cnjD-4el1A:
undetectable
6cnjE-4el1A:
undetectable		 6cnjD-4el1A:
11.62
6cnjE-4el1A:
12.05