SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4el8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 12 ILE A  20
LEU A 542
ASP A 619
PHE A 614
ALA A 623
 None
 1.14A 1axwA-4el8A:
undetectable		 1axwA-4el8A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		3 / 3 TRP A  62
ALA A 238
VAL A  66
 None
 0.72A 1bdwA-4el8A:
undetectable
1bdwB-4el8A:
undetectable		 1bdwA-4el8A:
2.45
1bdwB-4el8A:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 GLY A 289
LEU A 133
TYR A 290
GLU A 136
 None
 0.93A 1dmaA-4el8A:
undetectable		 1dmaA-4el8A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 12 PHE A  77
VAL A  61
LEU A  84
MET A 339
ALA A 258
 None
 1.35A 1e3vA-4el8A:
undetectable		 1e3vA-4el8A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 11 ARG A 179
PRO A 192
TYR A 161
TYR A 159
TRP A 565
 None
 1.45A 1e7wB-4el8A:
undetectable		 1e7wB-4el8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		3 / 3 TRP A 237
VAL A  61
TRP A  62
 None
 1.45A 1gmkC-4el8A:
undetectable
1gmkD-4el8A:
undetectable		 1gmkC-4el8A:
2.45
1gmkD-4el8A:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		3 / 3 TRP A 363
TYR A 394
LEU A 296
 None
SO4  A 702 (-3.7A)
None
 0.92A 1kxhA-4el8A:
undetectable		 1kxhA-4el8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 GLN A 416
PHE A 322
HIS A 321
ASN A 410
 None
 1.07A 1tt0A-4el8A:
undetectable		 1tt0A-4el8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 GLN A 416
PHE A 322
HIS A 321
ASN A 410
 None
 1.07A 1tt0B-4el8A:
undetectable		 1tt0B-4el8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 GLN A 416
PHE A 322
HIS A 321
ASN A 410
 None
 1.06A 1tt0C-4el8A:
undetectable		 1tt0C-4el8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 GLN A 416
PHE A 322
HIS A 321
ASN A 410
 None
 1.07A 1tt0D-4el8A:
undetectable		 1tt0D-4el8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.08A 1v54A-4el8A:
undetectable
1v54C-4el8A:
undetectable		 1v54A-4el8A:
20.22
1v54C-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.07A 1v54N-4el8A:
undetectable
1v54P-4el8A:
undetectable		 1v54N-4el8A:
20.22
1v54P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.08A 1v55A-4el8A:
1.8
1v55C-4el8A:
undetectable		 1v55A-4el8A:
20.22
1v55C-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 1v55C-4el8A:
undetectable
1v55N-4el8A:
1.8
1v55P-4el8A:
undetectable		 1v55C-4el8A:
17.87
1v55N-4el8A:
20.22
1v55P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 PHE A 581
PHE A 554
TYR A  48
TYR A 159
 None
 1.40A 2aoxA-4el8A:
undetectable		 2aoxA-4el8A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 TYR A  59
ASP A 619
SER A 499
TYR A 506
 None
 1.24A 2bteA-4el8A:
undetectable		 2bteA-4el8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 SER A 343
TYR A 267
GLN A 325
ASP A 349
 None
 1.33A 2cl5B-4el8A:
undetectable		 2cl5B-4el8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 5 TYR A 383
TYR A 273
ILE A 315
GLY A 381
 None
 1.36A 2du8G-4el8A:
undetectable		 2du8G-4el8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 2dyrA-4el8A:
1.8
2dyrC-4el8A:
undetectable		 2dyrA-4el8A:
20.22
2dyrC-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.08A 2dyrN-4el8A:
1.7
2dyrP-4el8A:
undetectable		 2dyrN-4el8A:
20.22
2dyrP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.07A 2dysA-4el8A:
1.7
2dysC-4el8A:
undetectable		 2dysA-4el8A:
20.22
2dysC-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.03A 2dysN-4el8A:
undetectable
2dysP-4el8A:
undetectable		 2dysN-4el8A:
20.22
2dysP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.05A 2eijA-4el8A:
1.8
2eijC-4el8A:
undetectable		 2eijA-4el8A:
20.22
2eijC-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.05A 2eijN-4el8A:
undetectable
2eijP-4el8A:
undetectable		 2eijN-4el8A:
20.22
2eijP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.08A 2eikA-4el8A:
undetectable
2eikC-4el8A:
undetectable		 2eikA-4el8A:
20.22
2eikC-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.06A 2eikN-4el8A:
undetectable
2eikP-4el8A:
undetectable		 2eikN-4el8A:
20.22
2eikP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 2eilA-4el8A:
undetectable
2eilC-4el8A:
undetectable		 2eilA-4el8A:
20.22
2eilC-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.06A 2eilN-4el8A:
1.7
2eilP-4el8A:
undetectable		 2eilN-4el8A:
20.22
2eilP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.03A 2eimA-4el8A:
undetectable
2eimC-4el8A:
undetectable		 2eimA-4el8A:
20.22
2eimC-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.05A 2eimN-4el8A:
2.2
2eimP-4el8A:
undetectable		 2eimN-4el8A:
20.22
2eimP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.03A 2einA-4el8A:
undetectable
2einC-4el8A:
undetectable		 2einA-4el8A:
20.22
2einC-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.07A 2einN-4el8A:
undetectable
2einP-4el8A:
undetectable		 2einN-4el8A:
20.22
2einP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 TYR A 386
TYR A 108
GLU A 111
HIS A 319
 None
 1.12A 2ha4A-4el8A:
undetectable		 2ha4A-4el8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 TYR A 386
TYR A 108
GLU A 111
HIS A 319
 None
 1.10A 2ha4B-4el8A:
undetectable		 2ha4B-4el8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 11 TRP A 299
PHE A 415
ALA A 417
SER A 499
ASP A 228
 None
 1.50A 2iyfA-4el8A:
undetectable		 2iyfA-4el8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		3 / 3 TRP A  62
ALA A 238
VAL A  66
 None
 0.93A 2izqC-4el8A:
undetectable
2izqD-4el8A:
undetectable		 2izqC-4el8A:
2.45
2izqD-4el8A:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 10 GLU A 546
ARG A 548
ILE A 496
GLU A  44
ASP A 550
 None
 1.31A 2qeoB-4el8A:
undetectable		 2qeoB-4el8A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 CYH A  43
ASP A  47
PHE A 581
TYR A 588
 None
 1.26A 2todA-4el8A:
undetectable
2todB-4el8A:
undetectable		 2todA-4el8A:
19.11
2todB-4el8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_B_DMOB700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 5 TYR A 588
CYH A  43
ASP A  47
PHE A 581
 None
 1.25A 2todA-4el8A:
0.0
2todB-4el8A:
0.0		 2todA-4el8A:
19.11
2todB-4el8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_C_DMOC700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 5 CYH A  43
ASP A  47
PHE A 581
TYR A 588
 None
 1.26A 2todC-4el8A:
undetectable
2todD-4el8A:
undetectable		 2todC-4el8A:
19.11
2todD-4el8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_D_DMOD700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 5 TYR A 588
CYH A  43
ASP A  47
PHE A 581
 None
 1.26A 2todC-4el8A:
undetectable
2todD-4el8A:
undetectable		 2todC-4el8A:
19.11
2todD-4el8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 9 LEU A  63
ILE A 620
ALA A 616
GLU A 539
GLY A  26
 None
 1.23A 2v0mB-4el8A:
undetectable		 2v0mB-4el8A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 TYR A 361
ILE A 358
TYR A 477
LEU A 439
 None
 0.81A 2w98B-4el8A:
undetectable		 2w98B-4el8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.06A 2y69A-4el8A:
undetectable
2y69C-4el8A:
undetectable		 2y69A-4el8A:
20.22
2y69C-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 2y69C-4el8A:
undetectable
2y69N-4el8A:
2.0
2y69P-4el8A:
undetectable		 2y69C-4el8A:
17.87
2y69N-4el8A:
20.22
2y69P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 SER A 343
TYR A 267
GLN A 325
ASP A 349
 None
 1.36A 2zvjA-4el8A:
undetectable		 2zvjA-4el8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 2zxwA-4el8A:
undetectable
2zxwC-4el8A:
undetectable		 2zxwA-4el8A:
20.22
2zxwC-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.06A 2zxwN-4el8A:
2.0
2zxwP-4el8A:
undetectable		 2zxwN-4el8A:
20.22
2zxwP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.11A 3abkA-4el8A:
undetectable
3abkC-4el8A:
undetectable		 3abkA-4el8A:
20.22
3abkC-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 3abkN-4el8A:
2.0
3abkP-4el8A:
undetectable		 3abkN-4el8A:
20.22
3abkP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 3ablA-4el8A:
1.7
3ablC-4el8A:
undetectable
3ablP-4el8A:
undetectable		 3ablA-4el8A:
20.22
3ablC-4el8A:
17.87
3ablP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.07A 3ablC-4el8A:
undetectable
3ablN-4el8A:
1.7
3ablP-4el8A:
undetectable		 3ablC-4el8A:
17.87
3ablN-4el8A:
20.22
3ablP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.06A 3abmA-4el8A:
undetectable
3abmC-4el8A:
undetectable
3abmP-4el8A:
undetectable		 3abmA-4el8A:
20.22
3abmC-4el8A:
17.87
3abmP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.06A 3abmN-4el8A:
undetectable
3abmP-4el8A:
undetectable		 3abmN-4el8A:
20.22
3abmP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.15A 3ag1A-4el8A:
2.0
3ag1C-4el8A:
1.2		 3ag1A-4el8A:
20.22
3ag1C-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.15A 3ag1N-4el8A:
undetectable
3ag1P-4el8A:
undetectable		 3ag1N-4el8A:
20.22
3ag1P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 3ag2A-4el8A:
undetectable
3ag2C-4el8A:
undetectable		 3ag2A-4el8A:
20.22
3ag2C-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 3ag2N-4el8A:
2.2
3ag2P-4el8A:
undetectable		 3ag2N-4el8A:
20.22
3ag2P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.12A 3ag3A-4el8A:
2.0
3ag3C-4el8A:
undetectable		 3ag3A-4el8A:
20.22
3ag3C-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.08A 3ag3N-4el8A:
undetectable
3ag3P-4el8A:
undetectable		 3ag3N-4el8A:
20.22
3ag3P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 3ag4A-4el8A:
undetectable
3ag4C-4el8A:
undetectable		 3ag4A-4el8A:
20.22
3ag4C-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.08A 3ag4N-4el8A:
undetectable
3ag4P-4el8A:
undetectable		 3ag4N-4el8A:
20.22
3ag4P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 3asnA-4el8A:
1.7
3asnC-4el8A:
undetectable		 3asnA-4el8A:
20.22
3asnC-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 3asnC-4el8A:
undetectable
3asnN-4el8A:
undetectable
3asnP-4el8A:
undetectable		 3asnC-4el8A:
17.87
3asnN-4el8A:
20.22
3asnP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 3asoA-4el8A:
1.6
3asoC-4el8A:
undetectable
3asoP-4el8A:
undetectable		 3asoA-4el8A:
20.22
3asoC-4el8A:
17.87
3asoP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.11A 3asoC-4el8A:
undetectable
3asoN-4el8A:
undetectable
3asoP-4el8A:
undetectable		 3asoC-4el8A:
17.87
3asoN-4el8A:
20.22
3asoP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 4 GLN A 357
GLN A 325
GLY A 323
HIS A 321
 None
 1.41A 3huoA-4el8A:
undetectable		 3huoA-4el8A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 GLN A 416
PHE A 322
HIS A 321
ASN A 410
 None
 1.07A 3lskB-4el8A:
undetectable		 3lskB-4el8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 GLN A 416
PHE A 322
HIS A 321
ASN A 410
 None
 1.03A 3lskD-4el8A:
undetectable		 3lskD-4el8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 12 VAL A 450
VAL A 446
GLY A 520
ALA A 521
LEU A 528
 None
 1.09A 3n8yB-4el8A:
undetectable		 3n8yB-4el8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 12 ARG A 613
GLN A 617
GLY A 495
GLU A 546
ALA A 544
 None
 1.34A 3t7sC-4el8A:
undetectable		 3t7sC-4el8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.08A 3wg7A-4el8A:
1.7
3wg7C-4el8A:
undetectable
3wg7P-4el8A:
undetectable		 3wg7A-4el8A:
20.22
3wg7C-4el8A:
17.87
3wg7P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.12A 3wg7C-4el8A:
undetectable
3wg7N-4el8A:
undetectable
3wg7P-4el8A:
undetectable		 3wg7C-4el8A:
17.87
3wg7N-4el8A:
20.22
3wg7P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.07A 3x2qA-4el8A:
1.7
3x2qC-4el8A:
undetectable
3x2qP-4el8A:
undetectable		 3x2qA-4el8A:
20.22
3x2qC-4el8A:
17.87
3x2qP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 3x2qC-4el8A:
undetectable
3x2qN-4el8A:
undetectable
3x2qP-4el8A:
undetectable		 3x2qC-4el8A:
17.87
3x2qN-4el8A:
20.22
3x2qP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 ALA A 503
ALA A 623
LEU A 505
THR A 626
 None
 0.85A 4dtzA-4el8A:
undetectable		 4dtzA-4el8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 12 PHE A 393
GLY A 395
ASP A 271
ALA A 375
VAL A 320
 None
 1.14A 4dx5B-4el8A:
undetectable		 4dx5B-4el8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 ILE A  89
PRO A  90
GLY A 304
GLN A 178
 None
 0.97A 4g0uB-4el8A:
undetectable		 4g0uB-4el8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 ASP A 156
ASN A 157
ALA A 171
TYR A  87
 None
 0.97A 4mdaA-4el8A:
undetectable		 4mdaA-4el8A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 ARG A 548
ASP A 550
LEU A  41
SER A  37
 None
 1.04A 4ot2A-4el8A:
undetectable		 4ot2A-4el8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 THR A 176
THR A 188
HIS A  36
LEU A 152
 None
 1.04A 4pgfA-4el8A:
undetectable		 4pgfA-4el8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 12 PHE A 393
GLY A 395
ASP A 271
ALA A 375
VAL A 320
 None
 1.13A 4u8vB-4el8A:
undetectable		 4u8vB-4el8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.08A 5b1aA-4el8A:
1.7
5b1aC-4el8A:
undetectable
5b1aP-4el8A:
undetectable		 5b1aA-4el8A:
20.22
5b1aC-4el8A:
17.87
5b1aP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 5b1aN-4el8A:
1.7
5b1aP-4el8A:
undetectable		 5b1aN-4el8A:
20.22
5b1aP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.08A 5b1bA-4el8A:
undetectable
5b1bC-4el8A:
undetectable
5b1bP-4el8A:
undetectable		 5b1bA-4el8A:
20.22
5b1bC-4el8A:
17.87
5b1bP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 5b1bN-4el8A:
undetectable
5b1bP-4el8A:
undetectable		 5b1bN-4el8A:
20.22
5b1bP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 ILE A 582
PHE A 581
THR A  40
LEU A  41
 None
 0.80A 5b1bN-4el8A:
0.2
5b1bW-4el8A:
undetectable		 5b1bN-4el8A:
20.22
5b1bW-4el8A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.13A 5b3sA-4el8A:
0.0
5b3sC-4el8A:
undetectable
5b3sP-4el8A:
undetectable		 5b3sA-4el8A:
20.22
5b3sC-4el8A:
17.87
5b3sP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.12A 5b3sN-4el8A:
undetectable
5b3sP-4el8A:
undetectable		 5b3sN-4el8A:
20.22
5b3sP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 ILE A 582
PHE A 581
THR A  40
LEU A  41
 None
 0.82A 5b3sN-4el8A:
undetectable
5b3sW-4el8A:
undetectable		 5b3sN-4el8A:
20.22
5b3sW-4el8A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.11A 5iy5A-4el8A:
1.7
5iy5C-4el8A:
undetectable		 5iy5A-4el8A:
20.22
5iy5C-4el8A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.13A 5iy5C-4el8A:
undetectable
5iy5N-4el8A:
1.5
5iy5P-4el8A:
undetectable		 5iy5C-4el8A:
17.71
5iy5N-4el8A:
20.22
5iy5P-4el8A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 ASP A 131
PRO A 132
TYR A 290
SER A 298
 None
 1.24A 5l1fC-4el8A:
undetectable		 5l1fC-4el8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 11 LEU A 494
GLY A 491
SER A 543
LEU A 542
ARG A 531
 None
 1.13A 5o96A-4el8A:
undetectable
5o96B-4el8A:
undetectable		 5o96A-4el8A:
15.91
5o96B-4el8A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 12 GLY A 572
GLY A 162
GLY A 200
VAL A 189
ILE A 584
 None
 0.94A 5tuiB-4el8A:
undetectable		 5tuiB-4el8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.15A 5w97A-4el8A:
1.5
5w97C-4el8A:
undetectable
5w97c-4el8A:
undetectable		 5w97A-4el8A:
20.22
5w97C-4el8A:
17.87
5w97c-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.13A 5w97C-4el8A:
undetectable
5w97a-4el8A:
1.5
5w97c-4el8A:
undetectable		 5w97C-4el8A:
17.87
5w97a-4el8A:
20.22
5w97c-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 5wauA-4el8A:
2.1
5wauC-4el8A:
undetectable
5wauc-4el8A:
undetectable		 5wauA-4el8A:
20.22
5wauC-4el8A:
17.87
5wauc-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.11A 5wauC-4el8A:
undetectable
5waua-4el8A:
2.1
5wauc-4el8A:
undetectable		 5wauC-4el8A:
17.87
5waua-4el8A:
20.22
5wauc-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 5x19A-4el8A:
undetectable
5x19C-4el8A:
undetectable
5x19P-4el8A:
undetectable		 5x19A-4el8A:
20.22
5x19C-4el8A:
17.87
5x19P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.11A 5x19N-4el8A:
0.6
5x19P-4el8A:
undetectable		 5x19N-4el8A:
20.22
5x19P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.15A 5x1bA-4el8A:
undetectable
5x1bC-4el8A:
undetectable
5x1bP-4el8A:
undetectable		 5x1bA-4el8A:
20.22
5x1bC-4el8A:
17.87
5x1bP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.14A 5x1bN-4el8A:
1.7
5x1bP-4el8A:
1.2		 5x1bN-4el8A:
20.22
5x1bP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.14A 5x1fA-4el8A:
1.7
5x1fC-4el8A:
undetectable
5x1fP-4el8A:
undetectable		 5x1fA-4el8A:
20.22
5x1fC-4el8A:
17.87
5x1fP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.16A 5x1fN-4el8A:
1.8
5x1fP-4el8A:
undetectable		 5x1fN-4el8A:
20.22
5x1fP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.12A 5xdqA-4el8A:
1.7
5xdqC-4el8A:
undetectable
5xdqP-4el8A:
undetectable		 5xdqA-4el8A:
20.22
5xdqC-4el8A:
17.87
5xdqP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.12A 5xdqC-4el8A:
undetectable
5xdqN-4el8A:
1.7
5xdqP-4el8A:
undetectable		 5xdqC-4el8A:
17.87
5xdqN-4el8A:
20.22
5xdqP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 5xdxC-4el8A:
undetectable
5xdxN-4el8A:
1.8
5xdxP-4el8A:
undetectable		 5xdxC-4el8A:
17.90
5xdxN-4el8A:
20.22
5xdxP-4el8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 12 GLU A 425
VAL A 423
PRO A 327
TRP A 350
GLY A 262
 None
 1.27A 5xioA-4el8A:
undetectable		 5xioA-4el8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.08A 5z84A-4el8A:
undetectable
5z84C-4el8A:
undetectable
5z84P-4el8A:
undetectable		 5z84A-4el8A:
20.22
5z84C-4el8A:
17.87
5z84P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 5z84C-4el8A:
undetectable
5z84N-4el8A:
undetectable
5z84P-4el8A:
undetectable		 5z84C-4el8A:
17.87
5z84N-4el8A:
20.22
5z84P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 5z85A-4el8A:
undetectable
5z85C-4el8A:
undetectable
5z85P-4el8A:
undetectable		 5z85A-4el8A:
20.22
5z85C-4el8A:
17.87
5z85P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 5z85C-4el8A:
undetectable
5z85N-4el8A:
undetectable
5z85P-4el8A:
undetectable		 5z85C-4el8A:
17.87
5z85N-4el8A:
20.22
5z85P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 5z86A-4el8A:
undetectable
5z86C-4el8A:
undetectable
5z86P-4el8A:
undetectable		 5z86A-4el8A:
20.22
5z86C-4el8A:
17.87
5z86P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 5z86C-4el8A:
undetectable
5z86N-4el8A:
undetectable
5z86P-4el8A:
undetectable		 5z86C-4el8A:
17.87
5z86N-4el8A:
20.22
5z86P-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 5zcoA-4el8A:
undetectable
5zcoC-4el8A:
undetectable
5zcoP-4el8A:
undetectable		 5zcoA-4el8A:
20.22
5zcoC-4el8A:
17.87
5zcoP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.10A 5zcoC-4el8A:
undetectable
5zcoN-4el8A:
1.7
5zcoP-4el8A:
undetectable		 5zcoC-4el8A:
17.87
5zcoN-4el8A:
20.22
5zcoP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 5zcpA-4el8A:
undetectable
5zcpC-4el8A:
undetectable
5zcpP-4el8A:
undetectable		 5zcpA-4el8A:
20.22
5zcpC-4el8A:
17.87
5zcpP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.08A 5zcpC-4el8A:
undetectable
5zcpN-4el8A:
1.7
5zcpP-4el8A:
undetectable		 5zcpC-4el8A:
17.87
5zcpN-4el8A:
20.22
5zcpP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 5zcqA-4el8A:
1.8
5zcqC-4el8A:
undetectable
5zcqP-4el8A:
undetectable		 5zcqA-4el8A:
20.22
5zcqC-4el8A:
17.87
5zcqP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.11A 5zcqN-4el8A:
1.7
5zcqP-4el8A:
undetectable		 5zcqN-4el8A:
20.22
5zcqP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 5 TYR A 506
GLN A 421
GLY A  10
ILE A 629
 None
 1.11A 6debB-4el8A:
undetectable		 6debB-4el8A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 11 ALA A 625
TRP A 241
GLU A 425
ALA A 623
LEU A 529
 None
 1.33A 6dk1B-4el8A:
undetectable		 6dk1B-4el8A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 5 TYR A 118
GLU A 111
TYR A 324
HIS A 319
 None
 1.34A 6ep4A-4el8A:
undetectable		 6ep4A-4el8A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		3 / 3 THR A 235
ALA A 258
LYS A 260
 None
 0.54A 6fgcA-4el8A:
undetectable		 6fgcA-4el8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		3 / 3 THR A 235
ALA A 258
LYS A 260
 None
 0.56A 6fgdA-4el8A:
undetectable		 6fgdA-4el8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 4 ARG A 548
GLU A 546
GLU A  44
ARG A 613
 None
 1.26A 6fk2A-4el8A:
undetectable		 6fk2A-4el8A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.09A 6nknA-4el8A:
undetectable
6nknC-4el8A:
undetectable		 6nknA-4el8A:
20.22
6nknC-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 8 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.13A 6nknC-4el8A:
undetectable
6nknN-4el8A:
undetectable
6nknP-4el8A:
undetectable		 6nknC-4el8A:
17.87
6nknN-4el8A:
20.22
6nknP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.16A 6nmfA-4el8A:
undetectable
6nmfC-4el8A:
undetectable
6nmfP-4el8A:
undetectable		 6nmfA-4el8A:
20.22
6nmfC-4el8A:
17.87
6nmfP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.19A 6nmfN-4el8A:
undetectable
6nmfP-4el8A:
undetectable		 6nmfN-4el8A:
20.22
6nmfP-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 6 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.11A 6nmpA-4el8A:
1.7
6nmpC-4el8A:
undetectable		 6nmpA-4el8A:
20.22
6nmpC-4el8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4el8 GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 HIS A 191
ASP A 223
THR A 222
TYR A 221
 None
 1.14A 6nmpN-4el8A:
undetectable
6nmpP-4el8A:
undetectable		 6nmpN-4el8A:
20.22
6nmpP-4el8A:
17.87