SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4elj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 6 GLY A 423
GLY A 449
TYR A 453
SER A 443
 None
 0.96A 1eswA-4eljA:
undetectable		 1eswA-4eljA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 486
TYR A 453
VAL A 531
LEU A 400
LEU A 461
 None
 1.27A 1mrqA-4eljA:
undetectable		 1mrqA-4eljA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 511
LYS A 508
ARG A 500
 None
 0.92A 1ra8A-4eljA:
undetectable		 1ra8A-4eljA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 8 TYR A 225
PHE A 226
ALA A 201
LEU A 303
 None
 1.08A 1x8vA-4eljA:
undetectable		 1x8vA-4eljA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		3 / 3 ASN A 519
ILE A 422
MET A 484
 None
 0.72A 2h42C-4eljA:
undetectable		 2h42C-4eljA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 172
GLU A 280
LEU A 220
MET A 219
PHE A 216
 None
 1.33A 2jj8C-4eljA:
undetectable		 2jj8C-4eljA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 569
PRO A 568
LEU A 572
 None
 0.58A 2po7B-4eljA:
undetectable		 2po7B-4eljA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 9 ILE A 214
PHE A 430
ALA A 431
VAL A 434
 None
 0.83A 2vufA-4eljA:
2.7		 2vufA-4eljA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 288
CYH A 221
ILE A 297
VAL A 190
TYR A 173
 None
 1.45A 3g8iA-4eljA:
undetectable		 3g8iA-4eljA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		3 / 3 PRO A  67
PHE A 115
ALA A 107
 None
 0.58A 3itaD-4eljA:
1.5		 3itaD-4eljA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 6 GLY A 100
LEU A 120
ASN A 123
GLU A 125
 None
 0.89A 3zqtA-4eljA:
undetectable		 3zqtA-4eljA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 5 MET A 695
LEU A 688
ARG A 661
SER A 567
 None
 0.90A 4kmmB-4eljA:
undetectable		 4kmmB-4eljA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 8 MET A 148
ALA A 147
THR A  77
VAL A  81
 None
 1.02A 4ltwA-4eljA:
undetectable		 4ltwA-4eljA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 277
LEU A 223
CYH A 169
VAL A 190
VAL A 243
 None
 1.49A 4mk4B-4eljA:
0.0		 4mk4B-4eljA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 724
ALA A 727
ARG A 668
ALA A 734
PHE A 721
 None
 1.49A 4zo1X-4eljA:
undetectable		 4zo1X-4eljA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 5 ASP A 701
THR A 738
GLN A 702
GLU A 559
 None
 1.25A 5k9dA-4eljA:
undetectable		 5k9dA-4eljA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 401
LEU A 400
MET A 457
LEU A 461
 None
 1.03A 5u4sA-4eljA:
undetectable		 5u4sA-4eljA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 12 PHE A 117
PHE A 104
ILE A 101
VAL A 128
PHE A 131
 None
 1.36A 6ap6B-4eljA:
undetectable		 6ap6B-4eljA:
17.81