SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4elk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4elk HY19.3 TCR BETA
CHAIN (MOUSE
VARIABLE DOMAIN,
HUMAN CONSTANT
DOMAIN)
(Mus
musculus) 		5 / 10 VAL B 121
VAL B 156
ILE B  14
PRO B 231
GLY B 217
 None
 1.46A 13gsA-4elkB:
undetectable		 13gsA-4elkB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4elk HY19.3 TCR BETA
CHAIN (MOUSE
VARIABLE DOMAIN,
HUMAN CONSTANT
DOMAIN)
(Mus
musculus) 		5 / 9 VAL B 121
VAL B 156
ILE B  14
PRO B 231
GLY B 217
 None
 1.46A 13gsB-4elkB:
undetectable		 13gsB-4elkB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4elk HY19.3 TCR BETA
CHAIN (MOUSE
VARIABLE DOMAIN,
HUMAN CONSTANT
DOMAIN)
(Mus
musculus) 		5 / 11 GLN B  12
THR B 113
LEU B 118
SER B  88
ILE B  80
 None
FMT  B 304 (-3.2A)
None
FMT  B 304 ( 4.4A)
None
 1.44A 4claA-4elkB:
undetectable		 4claA-4elkB:
21.83