SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ell'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 768
TYR A 756
PHE A 760
PHE A 721
 None
 1.20A 1e71M-4ellA:
undetectable		 1e71M-4ellA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 461
ALA A 490
GLY A 449
TYR A 453
PHE A 404
 None
 1.49A 1l5rA-4ellA:
undetectable		 1l5rA-4ellA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 12 TYR A 651
LEU A 694
GLU A 693
PHE A 570
ILE A 573
 None
 1.38A 1rnrB-4ellA:
undetectable		 1rnrB-4ellA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 12 ASP A 421
TYR A 454
TYR A 453
ILE A 422
ARG A 418
 None
 1.33A 1tmxB-4ellA:
undetectable		 1tmxB-4ellA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 8 LYS A 530
PHE A 526
LEU A 572
ASP A 479
 None
 1.05A 2bxkA-4ellA:
undetectable		 2bxkA-4ellA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 8 LEU A 486
PHE A 482
ALA A 602
ALA A 603
 None
 0.77A 3ax9B-4ellA:
undetectable		 3ax9B-4ellA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 7 PHE A 526
PHE A 650
PHE A 570
SER A 567
 None
 1.27A 3hggA-4ellA:
undetectable		 3hggA-4ellA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 8 SER A 485
TYR A 606
LEU A 569
PRO A 568
 None
 1.24A 3jq7B-4ellA:
undetectable		 3jq7B-4ellA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 5 MET A 695
LEU A 688
ARG A 661
SER A 567
 None
 0.94A 4kmmB-4ellA:
undetectable		 4kmmB-4ellA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 4 VAL A 493
ILE A 536
ASN A 541
VAL A 456
 None
 1.35A 5ajqA-4ellA:
undetectable		 5ajqA-4ellA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		3 / 3 ILE A 724
ILE A 753
MET A 708
 None
 0.68A 5i9yA-4ellA:
undetectable		 5i9yA-4ellA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 5 ASP A 701
THR A 738
GLN A 702
GLU A 559
 None
 1.22A 5k9dA-4ellA:
undetectable		 5k9dA-4ellA:
22.35