SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4elx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE
(Escherichia
coli) 		4 / 7 ILE A  37
LEU A  74
ARG A  64
THR A 117
 None
 1.12A 2zxwN-4elxA:
undetectable
2zxwW-4elxA:
undetectable		 2zxwN-4elxA:
18.85
2zxwW-4elxA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 210
ASP A  79
THR A  38
THR A  75
ILE A  73
 None
 1.15A 3a35A-4elxA:
undetectable		 3a35A-4elxA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 210
ASP A  79
THR A  38
THR A  75
ILE A  73
 None
 1.13A 3a35B-4elxA:
undetectable		 3a35B-4elxA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 210
ASP A  79
THR A  38
THR A  75
ILE A  73
 None
 1.17A 3a3bA-4elxA:
undetectable		 3a3bA-4elxA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE
(Escherichia
coli) 		3 / 3 TRP A 166
VAL A  53
ARG A  41
 None
 0.75A 3b0wA-4elxA:
undetectable		 3b0wA-4elxA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE
(Escherichia
coli) 		3 / 3 LYS A  80
TYR A 129
ARG A  45
 None
 1.39A 4gc9A-4elxA:
undetectable		 4gc9A-4elxA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE
(Escherichia
coli) 		4 / 7 ILE A 115
PHE A 111
VAL A 122
ILE A  72
 None
 0.94A 4zzbC-4elxA:
undetectable
4zzbD-4elxA:
undetectable		 4zzbC-4elxA:
20.96
4zzbD-4elxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE
(Escherichia
coli) 		5 / 6 ILE A  73
VAL A  13
VAL A 215
TRP A  15
SER A  30
 None
 1.45A 5jwaH-4elxA:
undetectable		 5jwaH-4elxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE
(Escherichia
coli) 		5 / 12 ARG A  45
SER A 161
GLY A 156
THR A 155
GLN A 189
 None
CL  A 302 ( 4.8A)
CL  A 302 (-3.5A)
CL  A 302 (-4.6A)
None
 1.42A 5oj0A-4elxA:
undetectable		 5oj0A-4elxA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE
(Escherichia
coli) 		4 / 6 MET A 227
ALA A 250
LEU A 249
ALA A 234
 None
 1.23A 6fosB-4elxA:
undetectable		 6fosB-4elxA:
14.84