SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ely'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4ely DNA GYRASE SUBUNIT A
(Shigella
flexneri) 		5 / 9 ALA A 455
LEU A 459
LEU A 461
ILE A 390
LEU A 396
 None
 1.47A 1ereA-4elyA:
undetectable		 1ereA-4elyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 4ely DNA GYRASE SUBUNIT A
(Shigella
flexneri) 		5 / 9 ALA A 455
LEU A 459
LEU A 461
ILE A 390
LEU A 396
 None
 1.47A 1ereB-4elyA:
undetectable		 1ereB-4elyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 4ely DNA GYRASE SUBUNIT A
(Shigella
flexneri) 		5 / 9 ALA A 455
LEU A 459
LEU A 461
ILE A 390
LEU A 396
 None
 1.47A 1ereC-4elyA:
undetectable		 1ereC-4elyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4ely DNA GYRASE SUBUNIT A
(Shigella
flexneri) 		5 / 10 LEU A 450
ALA A 386
LEU A 410
LEU A 461
ALA A 457
 None
 1.36A 1ie4A-4elyA:
undetectable
1ie4C-4elyA:
undetectable		 1ie4A-4elyA:
20.12
1ie4C-4elyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4ely DNA GYRASE SUBUNIT A
(Shigella
flexneri) 		5 / 10 ALA A 455
LEU A 459
LEU A 461
ILE A 390
LEU A 396
 None
 1.40A 1qkuA-4elyA:
undetectable		 1qkuA-4elyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 4ely DNA GYRASE SUBUNIT A
(Shigella
flexneri) 		5 / 10 ALA A 455
LEU A 459
LEU A 461
ILE A 390
LEU A 396
 None
 1.40A 1qkuB-4elyA:
undetectable		 1qkuB-4elyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 4ely DNA GYRASE SUBUNIT A
(Shigella
flexneri) 		5 / 10 ALA A 455
LEU A 459
LEU A 461
ILE A 390
LEU A 396
 None
 1.40A 1qkuC-4elyA:
undetectable		 1qkuC-4elyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4ely DNA GYRASE SUBUNIT A
(Shigella
flexneri) 		4 / 4 LEU A 474
PRO A 392
ILE A 458
LEU A 461
 None
 1.02A 1ya4B-4elyA:
undetectable		 1ya4B-4elyA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ely DNA GYRASE SUBUNIT A
(Shigella
flexneri) 		3 / 3 LYS A 465
ARG A 376
LEU A 383
 None
 1.20A 3v4tE-4elyA:
undetectable		 3v4tE-4elyA:
19.28