SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4em2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_A_115A2_2 (HMG-COA REDUCTASE)	4em2	UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus)	4 / 8	CYH A 142 HIS A 66 LEU A 137 LEU A 113	None	0.92A	1hwiB-4em2A: undetectable	1hwiB-4em2A: 16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_D_115D3_1 (HMG-COA REDUCTASE)	4em2	UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus)	4 / 8	CYH A 142 HIS A 66 LEU A 137 LEU A 113	None	0.94A	1hwiC-4em2A: undetectable	1hwiC-4em2A: 16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K8M_A_ACRA720_1 (ALPHA-AMYLASE, SUSG)	4em2	UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus)	4 / 7	GLU A 64 LEU A 113 LYS A 133 ASN A 111	None	1.38A	3k8mA-4em2A: undetectable	3k8mA-4em2A: 14.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EM0_B_KANB302_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	4em2	UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus)	11 / 11	TYR A 52 TYR A 55 LEU A 56 THR A 59 TYR A 70 TRP A 73 LEU A 74 ARG A 77 ARG A 94 VAL A 145 GLN A 149	SAL A 501 (-4.6A) SAL A 502 (-4.2A) SAL A 501 (-4.4A) SAL A 502 (-3.2A) SAL A 501 (-4.8A) SAL A 502 (-3.6A) SAL A 504 ( 3.8A) SAL A 501 ( 3.0A) SAL A 504 (-4.0A) SAL A 502 (-4.6A) SAL A 502 (-4.5A)	0.44A	4em0B-4em2A: 24.0	4em0B-4em2A: 100.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HWI_A_115A2_2","HMG-COA REDUCTASE;HMG-COA REDUCTASE","4em2","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","Staphylococcus aureus",4,"CYH A 142;HIS A  66;LEU A 137;LEU A 113","None","0.92A","1hwiB-4em2A:undetectable","1hwiB-4em2A:16.63"],["1HWI_D_115D3_1","HMG-COA REDUCTASE;HMG-COA REDUCTASE","4em2","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","Staphylococcus aureus",4,"CYH A 142;HIS A  66;LEU A 137;LEU A 113","None","0.94A","1hwiC-4em2A:undetectable","1hwiC-4em2A:16.63"],["3K8M_A_ACRA720_1","ALPHA-AMYLASE, SUSG","4em2","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","Staphylococcus aureus",4,"GLU A  64;LEU A 113;LYS A 133;ASN A 111","None","1.38A","3k8mA-4em2A:undetectable","3k8mA-4em2A:14.92"],["4EM0_B_KANB302_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","4em2","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","Staphylococcus aureus",11,"TYR A  52;TYR A  55;LEU A  56;THR A  59;TYR A  70;TRP A  73;LEU A  74;ARG A  77;ARG A  94;VAL A 145;GLN A 149","SAL A 501 (-4.6A);SAL A 502 (-4.2A);SAL A 501 (-4.4A);SAL A 502 (-3.2A);SAL A 501 (-4.8A);SAL A 502 (-3.6A);SAL A 504 ( 3.8A);SAL A 501 ( 3.0A);SAL A 504 (-4.0A);SAL A 502 (-4.6A);SAL A 502 (-4.5A)","0.44A","4em0B-4em2A:24.0","4em0B-4em2A:100.00"]]