SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4em8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B
(Anaplasma
phagocytophilum) 		5 / 12 LEU A  86
ALA A  85
ALA A 102
THR A 127
LEU A 130
 None
 1.08A 1cbrA-4em8A:
undetectable		 1cbrA-4em8A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B
(Anaplasma
phagocytophilum) 		5 / 12 LEU A  86
ALA A  85
ALA A 102
THR A 127
LEU A 130
 None
 1.08A 1cbrB-4em8A:
undetectable		 1cbrB-4em8A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B
(Anaplasma
phagocytophilum) 		4 / 7 LEU A 121
GLN A 118
PHE A 107
LEU A 105
 None
 1.04A 3ag2C-4em8A:
undetectable		 3ag2C-4em8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B
(Anaplasma
phagocytophilum) 		5 / 9 ALA A  12
ILE A  65
GLY A  69
ILE A  70
PRO A  46
 None
 1.27A 3u7sB-4em8A:
undetectable		 3u7sB-4em8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B
(Anaplasma
phagocytophilum) 		3 / 3 ASP A  10
GLY A  67
TYR A  45
 None
 0.76A 3w9tC-4em8A:
undetectable		 3w9tC-4em8A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B
(Anaplasma
phagocytophilum) 		3 / 3 ASP A  10
GLY A  67
TYR A  45
 None
 0.76A 3w9tG-4em8A:
undetectable		 3w9tG-4em8A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B
(Anaplasma
phagocytophilum) 		4 / 7 LEU A 121
GLN A 118
PHE A 107
LEU A 105
 None
 0.96A 3x2qC-4em8A:
undetectable
3x2qJ-4em8A:
undetectable		 3x2qC-4em8A:
18.77
3x2qJ-4em8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B
(Anaplasma
phagocytophilum) 		4 / 8 PHE A 107
PHE A 124
LEU A  24
LEU A  20
 None
 0.92A 4ejgB-4em8A:
undetectable		 4ejgB-4em8A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B
(Anaplasma
phagocytophilum) 		5 / 9 GLY A 108
SER A 109
ASP A  10
CYH A  66
GLY A  69
 None
 1.21A 4lb0A-4em8A:
undetectable		 4lb0A-4em8A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B
(Anaplasma
phagocytophilum) 		3 / 3 VAL A 104
ALA A  85
PHE A 124
 None
 0.75A 4z4iA-4em8A:
3.1		 4z4iA-4em8A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B
(Anaplasma
phagocytophilum) 		3 / 3 VAL A 104
ALA A  85
PHE A 124
 None
 0.76A 5js1A-4em8A:
undetectable		 5js1A-4em8A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B
(Anaplasma
phagocytophilum) 		4 / 7 LEU A 121
GLN A 118
PHE A 107
LEU A 105
 None
 0.97A 5zcqP-4em8A:
undetectable
5zcqW-4em8A:
undetectable		 5zcqP-4em8A:
18.77
5zcqW-4em8A:
22.06