SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4emb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		5 / 11 LEU A  70
VAL A  84
ILE A  82
LEU A  48
LEU A  77
 None
 1.18A 1mrqA-4embA:
undetectable		 1mrqA-4embA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 7 GLY A 234
GLN A  50
ILE A 215
PRO A 216
 None
 1.05A 1rxcC-4embA:
undetectable		 1rxcC-4embA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 7 GLY A 234
GLN A  50
ILE A 215
PRO A 216
 None
 0.97A 1rxcF-4embA:
undetectable		 1rxcF-4embA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 8 GLY A 234
GLN A  50
ILE A 215
PRO A 216
 None
 0.98A 1rxcI-4embA:
undetectable		 1rxcI-4embA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 7 GLY A 234
GLN A  50
ILE A 215
PRO A 216
 None
 0.95A 1rxcL-4embA:
undetectable		 1rxcL-4embA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		5 / 11 GLY A 188
SER A 190
ALA A  66
LEU A  63
VAL A 184
 None
 1.06A 1ukbA-4embA:
undetectable		 1ukbA-4embA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 7 ILE A 138
PRO A 125
GLY A  96
MET A 127
 None
 1.07A 2pnjB-4embA:
undetectable		 2pnjB-4embA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		5 / 9 ALA A 186
VAL A  12
GLY A  15
ILE A  73
LEU A  70
 None
 0.94A 2z0yA-4embA:
undetectable		 2z0yA-4embA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 179
ASP A 222
LEU A 221
ASN A 226
GLU A 175
 None
 1.09A 2zw9B-4embA:
undetectable		 2zw9B-4embA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		5 / 9 ALA A  66
VAL A  12
ILE A  73
ILE A  38
THR A 213
 None
 1.01A 3el4B-4embA:
undetectable		 3el4B-4embA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		5 / 10 ALA A  66
VAL A  12
ILE A  73
ILE A  38
THR A 213
 None
 1.04A 3el5A-4embA:
undetectable		 3el5A-4embA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		5 / 12 ALA A  66
GLY A  27
SER A  61
LEU A  90
SER A 190
 None
EDO  A 301 (-3.5A)
None
None
None
 0.97A 3gyqA-4embA:
undetectable
3gyqB-4embA:
undetectable		 3gyqA-4embA:
22.22
3gyqB-4embA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		5 / 8 ALA A 185
ILE A 183
LEU A  70
ALA A  44
ALA A  41
 None
 1.31A 3r9tA-4embA:
undetectable		 3r9tA-4embA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 7 GLY A 234
GLN A  50
ILE A 215
PRO A 216
 None
 1.00A 4e1vB-4embA:
undetectable		 4e1vB-4embA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 8 GLY A 234
GLN A  50
ILE A 215
PRO A 216
 None
 0.99A 4e1vC-4embA:
undetectable		 4e1vC-4embA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 8 GLY A 234
GLN A  50
ILE A 215
PRO A 216
 None
 0.99A 4e1vD-4embA:
undetectable		 4e1vD-4embA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 8 GLY A 234
GLN A  50
ILE A 215
PRO A 216
 None
 0.98A 4e1vE-4embA:
undetectable		 4e1vE-4embA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 8 GLY A 234
GLN A  50
ILE A 215
PRO A 216
 None
 0.98A 4e1vH-4embA:
undetectable		 4e1vH-4embA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		5 / 12 ALA A  66
VAL A  12
ILE A  73
ILE A  38
THR A 213
 None
 0.99A 4njuA-4embA:
undetectable		 4njuA-4embA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		5 / 12 ALA A  66
VAL A  12
ILE A  73
ILE A  38
THR A 213
 None
 0.99A 4njuC-4embA:
undetectable		 4njuC-4embA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 6 TYR A  53
GLU A 220
TYR A 231
LEU A 217
 None
 1.15A 4twdB-4embA:
undetectable
4twdC-4embA:
undetectable		 4twdB-4embA:
21.45
4twdC-4embA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 7 GLU A 220
TYR A 231
LEU A 217
TYR A  53
 None
 1.21A 4twdF-4embA:
undetectable
4twdJ-4embA:
undetectable		 4twdF-4embA:
21.45
4twdJ-4embA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 6 TYR A  53
GLU A 220
TYR A 231
LEU A 217
 None
 1.22A 4twdF-4embA:
undetectable
4twdG-4embA:
undetectable		 4twdF-4embA:
21.45
4twdG-4embA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 5 LEU A 194
ALA A 186
VAL A 182
ILE A 183
 None
 0.97A 4xe3A-4embA:
undetectable		 4xe3A-4embA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 5 LEU A 194
ALA A 186
VAL A 182
ILE A 183
 None
 0.88A 4xe3B-4embA:
undetectable		 4xe3B-4embA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 8 TYR A 219
ASP A 199
ILE A 228
TYR A 231
 None
 0.78A 4xjeA-4embA:
undetectable		 4xjeA-4embA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		5 / 12 LEU A  70
VAL A  84
ILE A  82
LEU A  48
LEU A  77
 None
 1.13A 4yvpB-4embA:
undetectable		 4yvpB-4embA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		4 / 8 TYR A 219
ASP A 199
ILE A 228
TYR A 231
 None
 0.97A 5cfsA-4embA:
undetectable		 5cfsA-4embA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Borreliella
burgdorferi) 		5 / 12 ASP A  35
ILE A  38
ARG A  65
HIS A 187
GLY A  37
 None
 1.00A 5k7uA-4embA:
1.9		 5k7uA-4embA:
22.88