SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4emd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Mycobacteroides
abscessus) 		4 / 8 SER A 263
VAL A 262
PRO A 267
VAL A 291
 None
 1.09A 1fduB-4emdA:
undetectable		 1fduB-4emdA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Mycobacteroides
abscessus) 		5 / 12 ASP A 117
GLY A 113
GLY A  68
ILE A  62
ILE A 101
 None
SO4  A 402 (-3.8A)
None
None
None
 0.94A 1hshC-4emdA:
undetectable		 1hshC-4emdA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Mycobacteroides
abscessus) 		5 / 11 ASP A 117
MET A 111
GLY A 109
GLY A  68
GLN A  67
 None
 1.34A 1jr1A-4emdA:
undetectable		 1jr1A-4emdA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A  29
ARG A 207
ILE A 196
PHE A 193
ALA A 238
 None
None
None
C5P  A 401 (-3.5A)
None
 1.37A 1oltA-4emdA:
undetectable		 1oltA-4emdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Mycobacteroides
abscessus) 		5 / 12 LEU A  24
VAL A  42
THR A 169
VAL A 170
GLY A 300
 None
 1.12A 2cbrA-4emdA:
undetectable		 2cbrA-4emdA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Mycobacteroides
abscessus) 		4 / 8 ALA A 287
GLY A 252
ALA A 181
CYH A 292
 None
 0.88A 2vh3B-4emdA:
undetectable		 2vh3B-4emdA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A  37
ILE A 196
ALA A 237
SER A 240
LEU A 241
 C5P  A 401 (-3.7A)
None
None
None
None
 0.85A 3n8xB-4emdA:
undetectable		 3n8xB-4emdA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Mycobacteroides
abscessus) 		5 / 9 GLY A 304
ALA A 305
ALA A  49
ASP A  50
ARG A  17
 None
 1.19A 3ur0C-4emdA:
undetectable		 3ur0C-4emdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Mycobacteroides
abscessus) 		5 / 12 ASP A 117
GLY A 114
GLY A 113
ALA A  49
GLY A  68
 None
SO4  A 402 (-3.4A)
SO4  A 402 (-3.8A)
None
None
 0.98A 4n09B-4emdA:
undetectable		 4n09B-4emdA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Mycobacteroides
abscessus) 		5 / 12 ASP A 117
GLY A 114
GLY A 113
ALA A  49
GLY A  68
 None
SO4  A 402 (-3.4A)
SO4  A 402 (-3.8A)
None
None
 0.97A 4n09D-4emdA:
undetectable		 4n09D-4emdA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Mycobacteroides
abscessus) 		4 / 6 LEU A  79
ASN A  78
LEU A 122
ILE A  99
 None
 1.08A 4okxA-4emdA:
undetectable		 4okxA-4emdA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Mycobacteroides
abscessus) 		5 / 11 GLY A 110
ALA A 238
SER A 263
ASN A  23
ASN A 232
 None
 1.24A 5x6yA-4emdA:
undetectable		 5x6yA-4emdA:
16.25