SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eme'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 8 GLY A 459
GLY A 528
MET A 436
LEU A 328
 None
 0.83A 1aegA-4emeA:
undetectable		 1aegA-4emeA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 8 GLN A 562
ASN A 561
LEU A  82
TYR A 372
 None
 0.99A 1hk3A-4emeA:
undetectable		 1hk3A-4emeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 SER A 392
ASP A 378
CYH A  27
 None
 0.89A 2br4E-4emeA:
undetectable		 2br4E-4emeA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 5 ILE A 109
PRO A 182
PHE A 154
PRO A 156
 None
 1.18A 3bjwC-4emeA:
undetectable		 3bjwC-4emeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 11 LEU A 153
VAL A 152
ILE A  95
LEU A 281
THR A 306
 None
 1.25A 3fl9C-4emeA:
undetectable		 3fl9C-4emeA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 9 LEU A 153
VAL A 152
ILE A  95
LEU A 281
THR A 306
 None
 1.27A 3fl9H-4emeA:
undetectable		 3fl9H-4emeA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 8 SER A 330
ASP A  89
ASP A 435
ASP A 325
 None
None
ZN  A1001 (-2.0A)
ZN  A1002 ( 2.6A)
 1.26A 3n2oC-4emeA:
undetectable
3n2oD-4emeA:
undetectable		 3n2oC-4emeA:
19.97
3n2oD-4emeA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 GLY A  21
LEU A 127
GLY A 128
ALA A  26
LEU A 327
 None
 1.04A 3vywC-4emeA:
undetectable		 3vywC-4emeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 GLY A  21
LEU A 303
GLY A 128
ALA A  26
LEU A 327
 None
 1.16A 3vywC-4emeA:
undetectable		 3vywC-4emeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 6 SER A  22
ASP A 378
ARG A  63
GLU A 300
 None
 0.90A 4eysA-4emeA:
undetectable		 4eysA-4emeA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 CYH A  27
ASN A  62
LYS A  31
 None
 1.39A 4k50A-4emeA:
undetectable		 4k50A-4emeA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		6 / 11 HIS A  87
ASP A 325
GLU A 380
GLU A 381
GLY A 509
HIS A 535
 ZN  A1001 (-3.5A)
ZN  A1002 ( 2.6A)
ZN  A1001 (-3.8A)
ZN  A1002 (-2.1A)
None
ZN  A1002 (-3.4A)
 0.66A 4pqaA-4emeA:
20.9		 4pqaA-4emeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 TYR A 497
ARG A 482
LYS A 481
 None
 1.22A 4wq5B-4emeA:
undetectable		 4wq5B-4emeA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 9 ARG A  19
ALA A  26
PHE A  16
GLU A  32
ILE A  88
 None
 1.43A 5i73A-4emeA:
undetectable		 5i73A-4emeA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 6 ASN A  64
CYH A  59
PHE A 398
SER A 386
 None
 1.49A 6a7pB-4emeA:
undetectable		 6a7pB-4emeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 6 PHE A 324
ARG A 323
LEU A 328
ALA A 541
 None
 1.01A 6b89B-4emeA:
undetectable		 6b89B-4emeA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 ILE A 402
PHE A  68
THR A 558
LEU A 340
SER A 405
 None
 1.29A 6baaE-4emeA:
0.0		 6baaE-4emeA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 ILE A 402
PHE A  68
THR A 558
LEU A 340
SER A 405
 None
 1.29A 6baaF-4emeA:
0.0		 6baaF-4emeA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 ILE A 402
PHE A  68
THR A 558
LEU A 340
SER A 405
 None
 1.30A 6baaG-4emeA:
0.0		 6baaG-4emeA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 4eme M18 ASPARTYL
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 ILE A 402
PHE A  68
THR A 558
LEU A 340
SER A 405
 None
 1.29A 6baaH-4emeA:
0.0		 6baaH-4emeA:
16.27