SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4emi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4emi TODA
(Pseudomonas
putida) 		4 / 6 LEU A  21
ILE A  33
TYR A  67
VAL A 104
 None
FAD  A 501 ( 4.6A)
None
None
 0.98A 1db1A-4emiA:
undetectable		 1db1A-4emiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4emi TODA
(Pseudomonas
putida) 		4 / 7 LEU A 195
THR A 160
GLY A 155
LEU A 179
 None
 0.91A 1gtiA-4emiA:
undetectable		 1gtiA-4emiA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 367
LEU A 198
HIS A 326
LEU A 195
THR A 196
 None
 1.10A 1jffB-4emiA:
undetectable		 1jffB-4emiA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 ARG A 226
ILE A 235
ILE A 171
ALA A 222
VAL A 220
 None
 0.99A 2b7zA-4emiA:
undetectable		 2b7zA-4emiA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 ARG A 226
ILE A 235
ILE A 171
ALA A 222
VAL A 220
 None
 0.98A 2b7zB-4emiA:
undetectable		 2b7zB-4emiA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 367
LEU A 198
HIS A 326
LEU A 195
THR A 196
 None
 1.10A 2hxfB-4emiA:
undetectable		 2hxfB-4emiA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 367
LEU A 198
HIS A 326
LEU A 195
THR A 196
 None
 1.10A 2hxhB-4emiA:
undetectable		 2hxhB-4emiA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 367
LEU A 198
HIS A 326
LEU A 195
THR A 196
 None
 1.10A 2p4nB-4emiA:
undetectable		 2p4nB-4emiA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 367
LEU A 198
HIS A 326
LEU A 195
THR A 196
 None
 1.10A 2wbeB-4emiA:
undetectable		 2wbeB-4emiA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 LEU A  46
VAL A 133
VAL A 158
LEU A 146
LEU A 165
 FAD  A 501 ( 3.9A)
None
None
None
None
 1.44A 2zlcA-4emiA:
undetectable		 2zlcA-4emiA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 367
LEU A 198
HIS A 326
LEU A 195
THR A 196
 None
 1.10A 3dcoB-4emiA:
undetectable		 3dcoB-4emiA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 367
LEU A 198
HIS A 326
LEU A 195
THR A 196
 None
 1.10A 3edlB-4emiA:
undetectable		 3edlB-4emiA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 367
LEU A 198
HIS A 326
LEU A 195
THR A 196
 None
 1.09A 3iz0B-4emiA:
undetectable		 3iz0B-4emiA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 PHE A  26
THR A  17
ALA A   6
LEU A  98
LEU A  32
 None
 1.32A 3lcvB-4emiA:
undetectable		 3lcvB-4emiA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 LEU A 394
ALA A 350
GLY A 349
GLY A 344
LEU A 352
 None
 1.12A 3ou6A-4emiA:
2.5		 3ou6A-4emiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 LEU A 394
ALA A 350
GLY A 349
GLY A 344
LEU A 352
 None
 1.14A 3ou6B-4emiA:
undetectable		 3ou6B-4emiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 LEU A 394
ALA A 350
GLY A 349
GLY A 344
LEU A 352
 None
 1.13A 3ou7A-4emiA:
undetectable		 3ou7A-4emiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 LEU A 394
ALA A 350
GLY A 349
GLY A 344
LEU A 352
 None
 1.13A 3ou7B-4emiA:
2.5		 3ou7B-4emiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 LEU A 394
ALA A 350
GLY A 349
GLY A 344
LEU A 352
 None
 1.12A 3ou7D-4emiA:
undetectable		 3ou7D-4emiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 270
LEU A  83
VAL A 276
GLY A 256
LEU A 251
 None
 1.02A 3pghC-4emiA:
undetectable		 3pghC-4emiA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 270
LEU A  83
VAL A 276
GLY A 256
LEU A 251
 None
 1.04A 3rr3A-4emiA:
undetectable		 3rr3A-4emiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 270
LEU A  83
VAL A 276
GLY A 256
LEU A 251
 None
 1.04A 3rr3B-4emiA:
undetectable		 3rr3B-4emiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4emi TODA
(Pseudomonas
putida) 		6 / 12 GLY A   9
GLY A  34
THR A  76
LEU A  75
ASP A 275
GLY A  14
 FAD  A 501 (-3.1A)
FAD  A 501 ( 3.4A)
None
None
FAD  A 501 (-2.8A)
None
 1.42A 3sglA-4emiA:
7.9		 3sglA-4emiA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4emi TODA
(Pseudomonas
putida) 		5 / 10 ALA A 249
ILE A 105
ILE A 258
ALA A 267
VAL A  85
 None
 0.98A 3t3cB-4emiA:
undetectable		 3t3cB-4emiA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 4emi TODA
(Pseudomonas
putida) 		4 / 5 PHE A 211
ALA A 222
THR A 206
LEU A 147
 None
 1.12A 3t3zC-4emiA:
undetectable		 3t3zC-4emiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 GLY A   9
GLY A 108
LEU A  75
GLY A  77
PRO A  40
 FAD  A 501 (-3.1A)
FAD  A 501 (-3.1A)
None
None
None
 1.04A 4blvA-4emiA:
undetectable		 4blvA-4emiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4emi TODA
(Pseudomonas
putida) 		4 / 7 ALA A  49
SER A  45
VAL A 133
ARG A 137
 None
 1.08A 4ijiH-4emiA:
undetectable		 4ijiH-4emiA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4emi TODA
(Pseudomonas
putida) 		5 / 9 ALA A 272
ALA A 277
VAL A  85
ALA A 246
ASP A 243
 None
 1.14A 4qvnK-4emiA:
undetectable
4qvnL-4emiA:
undetectable		 4qvnK-4emiA:
19.45
4qvnL-4emiA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4emi TODA
(Pseudomonas
putida) 		5 / 9 ALA A 272
ALA A 277
VAL A  85
ALA A 246
ASP A 243
 None
 1.15A 4qvnY-4emiA:
undetectable
4qvnZ-4emiA:
undetectable		 4qvnY-4emiA:
19.45
4qvnZ-4emiA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 4emi TODA
(Pseudomonas
putida) 		4 / 7 LEU A 179
ALA A 159
LEU A 195
ILE A 148
 None
 0.84A 4ubsA-4emiA:
undetectable		 4ubsA-4emiA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4emi TODA
(Pseudomonas
putida) 		3 / 3 ASP A 254
GLY A 256
ASP A 243
 None
 0.66A 4xdtA-4emiA:
undetectable		 4xdtA-4emiA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 GLY A 210
SER A 227
GLN A 219
SER A 223
VAL A 149
 None
None
None
None
NAD  A 502 (-4.2A)
 1.16A 5dpdB-4emiA:
undetectable		 5dpdB-4emiA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 367
LEU A 198
HIS A 326
LEU A 195
THR A 196
 None
 1.04A 5hnwB-4emiA:
undetectable		 5hnwB-4emiA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4emi TODA
(Pseudomonas
putida) 		5 / 12 VAL A 367
LEU A 198
HIS A 326
LEU A 195
THR A 196
 None
 1.09A 5hnyB-4emiA:
undetectable		 5hnyB-4emiA:
23.19