SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4emk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP A  46
GLY A  16
ILE A  15
PRO A  75
 None
 0.71A 1n49D-4emkA:
undetectable		 1n49D-4emkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A  73
LEU A  44
LEU A  64
LEU A  19
 None
 1.07A 1yajD-4emkA:
undetectable		 1yajD-4emkA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe) 		4 / 6 ALA B  60
TYR B  27
ILE C  96
ILE B  62
 None
 1.15A 2dcfA-4emkB:
undetectable		 2dcfA-4emkB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 11 LEU A  44
LEU A  65
ILE A  11
ASN C  58
MET A  23
 None
 1.01A 2ft9A-4emkA:
undetectable		 2ft9A-4emkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
(Schizosaccharomy
ces
pombe) 		3 / 3 ASN A  18
ILE A  42
MET A  63
 None
 0.82A 2h42C-4emkA:
undetectable		 2h42C-4emkA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A  42
ILE A  11
LEU A  19
ASN A  18
VAL C  87
 None
 1.01A 2nnhA-4emkA:
undetectable		 2nnhA-4emkA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A  10
VAL C  88
ILE C  46
GLY C  48
ILE C  49
 None
 0.93A 2nnpB-4emkA:
undetectable		 2nnpB-4emkA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 7 ILE C  46
PRO A   7
GLY C  90
MET C  57
 None
 1.20A 2pnjB-4emkC:
undetectable		 2pnjB-4emkC:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 PRO A   7
ASN C  58
ARG C  89
 None
 1.07A 2qeuB-4emkA:
undetectable		 2qeuB-4emkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe) 		4 / 7 ALA B  60
TYR B  27
ILE C  96
ILE B  62
 None
 1.13A 2zm7A-4emkB:
undetectable		 2zm7A-4emkB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A  10
VAL C  88
ILE C  46
GLY C  48
ILE C  49
 None
 1.09A 3ekqB-4emkA:
undetectable		 3ekqB-4emkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A  10
VAL C  88
ILE C  46
GLY C  48
ILE C  49
 None
 1.16A 3el5A-4emkA:
undetectable		 3el5A-4emkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  10
VAL C  88
ILE C  46
GLY C  48
ILE C  49
 None
 0.96A 3spkB-4emkA:
undetectable		 3spkB-4emkA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR B  57
THR B  54
VAL B  25
VAL B  49
 None
 0.85A 4cp4A-4emkB:
undetectable		 4cp4A-4emkB:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  10
VAL C  88
ILE C  46
GLY C  48
ILE C  49
 None
 1.06A 4njuA-4emkA:
undetectable		 4njuA-4emkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  10
VAL C  88
ILE C  46
GLY C  48
ILE C  49
 None
 1.05A 4njuC-4emkA:
undetectable		 4njuC-4emkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A  10
GLY C  84
VAL C  88
GLY C  48
ILE C  49
 None
 0.89A 4rvjB-4emkA:
undetectable		 4rvjB-4emkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY B  64
ASN B  65
LEU B  18
ASP B  26
ALA B  72
 None
 1.08A 4uckB-4emkB:
undetectable		 4uckB-4emkB:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 PRO A  75
ILE C  46
LEU C  85
VAL C  87
THR C  92
 None
 1.30A 5bykA-4emkA:
undetectable		 5bykA-4emkA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A  31
LEU A  33
MET A  23
ARG A  27
LEU A  65
 None
 1.49A 5emlA-4emkA:
undetectable		 5emlA-4emkA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A  10
VAL C  88
ILE C  46
GLY C  48
ILE C  49
 None
 0.93A 5kqxB-4emkA:
undetectable		 5kqxB-4emkA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 PRO A  75
ILE C  46
LEU C  85
VAL C  87
THR C  92
 None
 1.28A 5tiwB-4emkA:
undetectable		 5tiwB-4emkA:
15.38