SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4emw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 ALA A 301
VAL A 305
ALA A 302
HIS A 299
 None
None
None
CAJ  A 503 (-4.1A)
 1.03A 1q23A-4emwA:
undetectable		 1q23A-4emwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 ALA A 301
VAL A 305
ALA A 302
HIS A 299
 None
None
None
CAJ  A 503 (-4.1A)
 1.05A 1q23K-4emwA:
undetectable		 1q23K-4emwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 SER A  39
ALA A 306
ILE A 309
ILE A  20
ALA A  17
 CAJ  A 503 (-3.0A)
None
None
None
None
 0.99A 2bxcA-4emwA:
undetectable		 2bxcA-4emwA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA A 279
GLY A  12
PRO A 113
GLY A 114
ALA A 302
 None
FAD  A 501 (-3.6A)
FAD  A 501 (-4.3A)
FAD  A 501 (-3.5A)
None
 0.71A 2plwA-4emwA:
4.0		 2plwA-4emwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		4 / 7 THR A 267
ILE A 272
PHE A 245
ILE A 246
 None
None
FAD  A 501 (-3.7A)
None
 0.86A 2y7wC-4emwA:
undetectable		 2y7wC-4emwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA A 279
GLY A  12
PRO A 113
GLY A 114
ALA A 302
 None
FAD  A 501 (-3.6A)
FAD  A 501 (-4.3A)
FAD  A 501 (-3.5A)
None
 0.78A 3douA-4emwA:
undetectable		 3douA-4emwA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 ILE A  31
PHE A  67
ILE A  73
THR A  77
 None
 1.13A 3ia4A-4emwA:
undetectable		 3ia4A-4emwA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 LEU A 109
GLY A   8
GLY A 276
ILE A 278
ILE A 110
 None
FAD  A 501 (-3.1A)
FAD  A 501 (-3.2A)
None
None
 0.93A 3jvyB-4emwA:
undetectable		 3jvyB-4emwA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 LEU A 109
GLY A   8
GLY A 276
ILE A 278
ILE A 110
 None
FAD  A 501 (-3.1A)
FAD  A 501 (-3.2A)
None
None
 0.95A 3nduC-4emwA:
undetectable		 3nduC-4emwA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 9 LEU A 109
GLY A   8
GLY A 276
ILE A 278
ILE A 110
 None
FAD  A 501 (-3.1A)
FAD  A 501 (-3.2A)
None
None
 0.94A 3nujB-4emwA:
undetectable		 3nujB-4emwA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 9 LEU A 109
GLY A   8
GLY A 276
ILE A 278
ILE A 110
 None
FAD  A 501 (-3.1A)
FAD  A 501 (-3.2A)
None
None
 0.94A 3nuoB-4emwA:
undetectable		 3nuoB-4emwA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 9 GLY A 391
ALA A 392
ASP A 393
ILE A 325
ILE A 430
 None
 1.04A 3ogpB-4emwA:
undetectable		 3ogpB-4emwA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 LEU A 109
GLY A   8
GLY A 276
ILE A 278
ILE A 110
 None
FAD  A 501 (-3.1A)
FAD  A 501 (-3.2A)
None
None
 0.96A 3pwmB-4emwA:
undetectable		 3pwmB-4emwA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ALA A 290
VAL A 261
ILE A 278
ALA A 274
ALA A 301
 None
 1.05A 4j14A-4emwA:
undetectable		 4j14A-4emwA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		3 / 3 LEU A 370
MET A 350
TYR A 435
 None
 0.71A 4p6xG-4emwA:
undetectable		 4p6xG-4emwA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ASP A 135
ASP A  35
ASN A 242
GLY A 114
PHE A  40
 None
FAD  A 501 (-3.8A)
FAD  A 501 (-4.2A)
FAD  A 501 (-3.5A)
None
 1.18A 4pgfA-4emwA:
3.7		 4pgfA-4emwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 ILE A 272
ASN A 271
ILE A 309
VAL A 305
 None
 1.30A 4uy87-4emwA:
undetectable		 4uy87-4emwA:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 PHE A 320
TYR A 158
GLY A 297
SER A 291
GLY A 322
 None
FAD  A 501 (-4.9A)
None
None
None
 1.47A 4xpbA-4emwA:
undetectable		 4xpbA-4emwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_A_ACTA404_0
(PROTON-GATED ION
CHANNEL)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 LEU A 152
ILE A 220
ARG A 207
TYR A 230
 None
 1.28A 4zzbA-4emwA:
undetectable		 4zzbA-4emwA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC404_0
(PROTON-GATED ION
CHANNEL)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 ILE A 220
ILE A 177
ARG A 207
TYR A 230
 None
 1.37A 4zzbC-4emwA:
0.3		 4zzbC-4emwA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA406_0
(PROTON-GATED ION
CHANNEL)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 LEU A 152
ILE A 220
ARG A 207
TYR A 230
 None
 1.31A 4zzcA-4emwA:
undetectable		 4zzcA-4emwA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB406_0
(PROTON-GATED ION
CHANNEL)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 LEU A 152
ILE A 220
ARG A 207
TYR A 230
 None
 1.35A 4zzcB-4emwA:
undetectable		 4zzcB-4emwA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC407_0
(PROTON-GATED ION
CHANNEL)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 ILE A 220
ILE A 177
ARG A 207
TYR A 230
 None
 1.39A 4zzcC-4emwA:
0.0		 4zzcC-4emwA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD406_0
(PROTON-GATED ION
CHANNEL)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 ILE A 220
ILE A 177
ARG A 207
TYR A 230
 None
 1.38A 4zzcD-4emwA:
undetectable		 4zzcD-4emwA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		4 / 8 ASP A 277
PHE A 258
ASN A 242
SER A 291
 FAD  A 501 (-2.9A)
None
FAD  A 501 (-4.2A)
None
 1.04A 5l1fA-4emwA:
undetectable
5l1fB-4emwA:
undetectable		 5l1fA-4emwA:
20.90
5l1fB-4emwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 VAL A   7
GLY A   8
GLU A  33
LYS A  34
ASN A 242
 FAD  A 501 (-4.8A)
FAD  A 501 (-3.1A)
FAD  A 501 (-2.7A)
FAD  A 501 (-2.7A)
FAD  A 501 (-4.2A)
 1.21A 5x6yA-4emwA:
undetectable		 5x6yA-4emwA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 LEU A 109
ILE A 259
LEU A 253
ASN A  85
ALA A  83
 None
 1.26A 5y7pB-4emwA:
undetectable		 5y7pB-4emwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 LEU A 109
ILE A 259
LEU A 253
ASN A  85
ALA A  83
 None
 1.25A 5y7pD-4emwA:
undetectable		 5y7pD-4emwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 LEU A 109
ILE A 259
LEU A 253
ASN A  85
ALA A  83
 None
 1.26A 5y7pH-4emwA:
undetectable		 5y7pH-4emwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		3 / 3 ARG A 371
ARG A 383
ASP A 188
 None
 0.86A 6d8pA-4emwA:
undetectable		 6d8pA-4emwA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4emw COENZYME A DISULFIDE
REDUCTASE
(Staphylococcus
aureus) 		3 / 3 ARG A 383
ARG A 371
ASP A 188
 None
 0.89A 6d8pA-4emwA:
undetectable		 6d8pA-4emwA:
20.91