SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4en8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		5 / 12 THR B 508
ILE B 479
ILE B 481
TYR B 404
TYR B 454
 None
 1.27A 1jtxA-4en8B:
undetectable		 1jtxA-4en8B:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		4 / 8 GLY B 212
TYR B 214
GLU B 377
TYR B 454
 None
 1.06A 1maaD-4en8B:
undetectable		 1maaD-4en8B:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		4 / 7 TYR B 454
TYR B 613
TYR B 214
ILE B 369
 None
 1.20A 2ph9A-4en8B:
undetectable
2ph9B-4en8B:
undetectable		 2ph9A-4en8B:
20.62
2ph9B-4en8B:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		4 / 7 ILE B 428
PHE B 407
ILE B 382
PHE B 494
 None
 1.25A 2qb4A-4en8B:
undetectable		 2qb4A-4en8B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		4 / 8 ALA B 463
GLY B 457
ILE B 427
THR B 419
 None
 0.85A 3el9A-4en8B:
undetectable		 3el9A-4en8B:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		3 / 3 TYR B 429
TYR B 214
GLU B 377
 None
 0.95A 3pfgA-4en8B:
undetectable		 3pfgA-4en8B:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		4 / 6 ILE B 602
PHE B 603
ILE B 468
LEU B 577
 None
 0.53A 4o8fB-4en8B:
undetectable		 4o8fB-4en8B:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		3 / 3 LEU B 587
ARG B 555
ARG B 557
 None
 0.93A 4yiaB-4en8B:
undetectable		 4yiaB-4en8B:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		4 / 4 LYS B 336
ASP B 355
GLU B 338
THR B 362
 None
 1.21A 5d4uA-4en8B:
undetectable		 5d4uA-4en8B:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		4 / 4 LYS B 336
ASP B 355
GLU B 338
THR B 362
 None
 1.20A 5d4uB-4en8B:
undetectable		 5d4uB-4en8B:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		4 / 4 LYS B 336
ASP B 355
GLU B 338
THR B 362
 None
 1.20A 5d4uC-4en8B:
undetectable		 5d4uC-4en8B:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		4 / 4 LYS B 336
ASP B 355
GLU B 338
THR B 362
 None
 1.21A 5d4uD-4en8B:
undetectable		 5d4uD-4en8B:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		4 / 6 TYR B 613
ILE B 316
TYR B 214
TYR B 429
 None
 1.46A 5igyA-4en8B:
undetectable		 5igyA-4en8B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53
(Clostridium
botulinum) 		3 / 3 TYR B 536
ARG B 525
THR B 508
 None
SIA  B 701 (-3.0A)
None
 0.73A 5z84J-4en8B:
undetectable		 5z84J-4en8B:
9.97