SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eo4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NYR_A_THRA1004_0
(THREONYL-TRNA
SYNTHETASE 1)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		8 / 10 MET A 131
CYH A 133
ARG A 162
ASP A 182
HIS A 184
TYR A 270
GLN A 292
HIS A 319
 SSA  A1001 (-3.8A)
ZN  A1003 (-2.9A)
SSA  A1001 (-2.8A)
SSA  A1001 (-2.8A)
ZN  A1003 (-3.6A)
None
SSA  A1001 (-3.3A)
ZN  A1003 ( 3.5A)
 0.34A 1nyrA-4eo4A:
47.7		 1nyrA-4eo4A:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NYR_B_THRB2004_0
(THREONYL-TRNA
SYNTHETASE 1)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		8 / 10 MET A 131
CYH A 133
ARG A 162
ASP A 182
HIS A 184
TYR A 270
GLN A 292
HIS A 319
 SSA  A1001 (-3.8A)
ZN  A1003 (-2.9A)
SSA  A1001 (-2.8A)
SSA  A1001 (-2.8A)
ZN  A1003 (-3.6A)
None
SSA  A1001 (-3.3A)
ZN  A1003 ( 3.5A)
 0.78A 1nyrB-4eo4A:
45.5		 1nyrB-4eo4A:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  95
ARG A 162
GLN A 180
 None
SSA  A1001 (-2.8A)
SSA  A1001 (-3.4A)
 0.94A 1tw4A-4eo4A:
undetectable		 1tw4A-4eo4A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 109
ARG A 162
TYR A 270
GLY A 267
ALA A 268
 None
SSA  A1001 (-2.8A)
None
None
None
 1.20A 2cojA-4eo4A:
undetectable
2cojB-4eo4A:
undetectable		 2cojA-4eo4A:
20.78
2cojB-4eo4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 272
THR A 230
PRO A 232
 None
 0.65A 2d55C-4eo4A:
undetectable		 2d55C-4eo4A:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 417
ASN A 346
GLU A 458
PHE A 343
 None
 1.13A 2fl5E-4eo4A:
undetectable
2fl5F-4eo4A:
undetectable		 2fl5E-4eo4A:
18.61
2fl5F-4eo4A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 233
PHE A 235
PRO A 232
THR A 230
 None
 1.15A 2q6oB-4eo4A:
2.7		 2q6oB-4eo4A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 184
HIS A 319
MET A 317
 ZN  A1003 (-3.6A)
ZN  A1003 ( 3.5A)
None
 0.88A 3mihA-4eo4A:
undetectable		 3mihA-4eo4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 226
ASN A 223
TYR A 207
ILE A 276
 None
 0.96A 4jtpA-4eo4A:
undetectable		 4jtpA-4eo4A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 8 ARG A 162
PHE A 178
GLN A 287
THR A 290
ARG A 328
 SSA  A1001 (-2.8A)
SSA  A1001 (-3.8A)
SSA  A1001 (-3.6A)
SSA  A1001 ( 4.3A)
SSA  A1001 (-3.7A)
 0.50A 4k87A-4eo4A:
26.5		 4k87A-4eo4A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 PRO A 315
HIS A 184
LEU A 249
PHE A 269
 None
ZN  A1003 (-3.6A)
None
None
 1.38A 5igjA-4eo4A:
undetectable		 5igjA-4eo4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 296
PHE A 269
CYH A 137
PHE A 186
 None
 1.45A 5mwyA-4eo4A:
undetectable		 5mwyA-4eo4A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 278
LEU A 333
PHE A 211
GLY A 324
ALA A 289
 None
None
None
SSA  A1001 (-3.3A)
None
 1.15A 5mxbA-4eo4A:
1.1		 5mxbA-4eo4A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 234
ASN A 108
ALA A 110
 None
 0.73A 5n4tB-4eo4A:
undetectable		 5n4tB-4eo4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 164
PRO A 130
ARG A 162
HIS A 184
THR A 290
 SSA  A1001 (-4.1A)
None
SSA  A1001 (-2.8A)
ZN  A1003 (-3.6A)
SSA  A1001 ( 4.3A)
 1.28A 5xioB-4eo4A:
26.9		 5xioB-4eo4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 164
PRO A 130
ARG A 162
HIS A 184
THR A 290
 SSA  A1001 (-4.1A)
None
SSA  A1001 (-2.8A)
ZN  A1003 (-3.6A)
SSA  A1001 ( 4.3A)
 1.34A 5xiqB-4eo4A:
26.8		 5xiqB-4eo4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 MET A 277
ASP A 266
ARG A 162
 None
None
SSA  A1001 (-2.8A)
 0.84A 5z6jA-4eo4A:
undetectable		 5z6jA-4eo4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 MET A 277
ASP A 266
ARG A 162
 None
None
SSA  A1001 (-2.8A)
 0.78A 5z6kA-4eo4A:
undetectable		 5z6kA-4eo4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 455
PHE A 392
ASN A 432
TYR A 417
 None
 1.18A 6a93B-4eo4A:
undetectable		 6a93B-4eo4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ARG A 162
GLU A 164
PHE A 178
GLY A 324
ARG A 328
 SSA  A1001 (-2.8A)
SSA  A1001 (-4.1A)
SSA  A1001 (-3.8A)
SSA  A1001 (-3.3A)
SSA  A1001 (-3.7A)
 0.69A 6bniA-4eo4A:
11.4		 6bniA-4eo4A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ARG A 162
GLU A 164
PHE A 178
GLY A 324
ARG A 328
 SSA  A1001 (-2.8A)
SSA  A1001 (-4.1A)
SSA  A1001 (-3.8A)
SSA  A1001 (-3.3A)
SSA  A1001 (-3.7A)
 0.67A 6bniB-4eo4A:
12.8		 6bniB-4eo4A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ASN A  64
PRO A 347
GLN A 349
 None
 0.91A 6jnhA-4eo4A:
undetectable		 6jnhA-4eo4A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ASN A  64
PRO A 347
GLN A 349
 None
 0.95A 6jogA-4eo4A:
undetectable		 6jogA-4eo4A:
17.37