SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eo9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
leprae) 		5 / 12 LEU A   9
GLY A  45
ILE A  82
LEU A  58
VAL A 183
 None
 1.00A 3adxB-4eo9A:
undetectable		 3adxB-4eo9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
leprae) 		5 / 12 ILE A 182
ALA A 184
PHE A 162
ARG A 161
LEU A  90
 None
 1.02A 3dzuA-4eo9A:
undetectable		 3dzuA-4eo9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
leprae) 		5 / 12 ILE A 182
ALA A 184
PHE A 162
ARG A 161
LEU A  90
 None
 1.07A 3dzyA-4eo9A:
undetectable		 3dzyA-4eo9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
leprae) 		5 / 12 LEU A 192
HIS A 195
TYR A 217
LEU A  11
THR A   8
 None
 1.19A 3thrA-4eo9A:
undetectable
3thrB-4eo9A:
undetectable
3thrC-4eo9A:
undetectable
3thrD-4eo9A:
undetectable		 3thrA-4eo9A:
24.05
3thrB-4eo9A:
24.05
3thrC-4eo9A:
24.05
3thrD-4eo9A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
leprae) 		3 / 3 MET A 199
GLU A 203
LEU A 207
 None
 0.77A 4v2oB-4eo9A:
undetectable		 4v2oB-4eo9A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
leprae) 		4 / 8 ILE A 213
PRO A 235
ALA A 238
PRO A 225
 None
 1.05A 5m0oC-4eo9A:
undetectable		 5m0oC-4eo9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
leprae) 		4 / 5 ILE A 182
TYR A 165
ARG A  89
THR A 167
 None
 1.24A 5z84N-4eo9A:
undetectable
5z84W-4eo9A:
undetectable		 5z84N-4eo9A:
18.92
5z84W-4eo9A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
leprae) 		4 / 6 ASP A 173
LEU A  90
SER A  87
PHE A 162
 None
 1.05A 6ekuA-4eo9A:
undetectable		 6ekuA-4eo9A:
16.67