SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eoc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 LEU A 243
ASP A 245
GLU A  76
ARG A  71
 BLA  A1001 (-4.6A)
None
None
None
 1.10A 1mt1A-4eocA:
undetectable
1mt1F-4eocA:
undetectable		 1mt1A-4eocA:
17.31
1mt1F-4eocA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 GLU A  76
ARG A  71
LEU A 243
ASP A 245
 None
None
BLA  A1001 (-4.6A)
None
 1.03A 1n13B-4eocA:
undetectable
1n13C-4eocA:
undetectable		 1n13B-4eocA:
19.83
1n13C-4eocA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 LEU A 243
ASP A 245
GLU A  76
ARG A  71
 BLA  A1001 (-4.6A)
None
None
None
 1.00A 1n13I-4eocA:
undetectable
1n13L-4eocA:
undetectable		 1n13I-4eocA:
17.31
1n13L-4eocA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ASP A 119
TYR A 212
PRO A 122
THR A 123
 None
 1.28A 2q6kA-4eocA:
undetectable		 2q6kA-4eocA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 PRO A 167
CYH A 104
ILE A 106
ILE A 165
PHE A 158
 None
None
None
None
BLA  A1001 (-4.4A)
 1.28A 4a79B-4eocA:
undetectable		 4a79B-4eocA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 SER A 121
GLN A 216
TYR A 212
ASP A 105
 None
BLA  A1001 (-3.5A)
None
BLA  A1001 (-2.8A)
 1.24A 4hxyB-4eocA:
undetectable		 4hxyB-4eocA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  87
LEU A  24
ALA A  25
LEU A 184
LEU A  75
 None
 1.24A 4p65A-4eocA:
undetectable
4p65B-4eocA:
undetectable
4p65F-4eocA:
undetectable
4p65H-4eocA:
undetectable		 4p65A-4eocA:
8.67
4p65B-4eocA:
9.74
4p65F-4eocA:
9.74
4p65H-4eocA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 PRO A  36
LEU A  35
HIS A 187
 None
CSO  A 188 ( 4.5A)
CSO  A 188 ( 4.7A)
 0.62A 4pevA-4eocA:
undetectable		 4pevA-4eocA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 ALA A 118
PHE A 158
GLN A 216
 None
BLA  A1001 (-4.4A)
BLA  A1001 (-3.5A)
 0.81A 6eceA-4eocA:
undetectable		 6eceA-4eocA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 208
GLN A 209
HIS A 187
TYR A 133
LEU A 129
 None
None
CSO  A 188 ( 4.7A)
None
None
 1.20A 6md4A-4eocA:
undetectable		 6md4A-4eocA:
15.61