SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo
sapiens)
4 / 8 GLY H  33
ALA H  24
THR H  53
ILE H  34
None
0.69A 1c9sI-4eowH:
undetectable
1c9sJ-4eowH:
undetectable
1c9sI-4eowH:
14.91
1c9sJ-4eowH:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo
sapiens)
4 / 8 GLY H  33
ALA H  24
THR H  53
ILE H  34
None
0.71A 1c9sU-4eowH:
undetectable
1c9sV-4eowH:
undetectable
1c9sU-4eowH:
14.91
1c9sV-4eowH:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo
sapiens)
4 / 7 GLY H  33
ALA H  24
THR H  53
ILE H  34
None
0.69A 1gtnA-4eowH:
1.4
1gtnK-4eowH:
undetectable
1gtnA-4eowH:
14.91
1gtnK-4eowH:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo
sapiens)
4 / 8 GLY H  33
ALA H  24
THR H  53
ILE H  34
None
0.71A 1gtnE-4eowH:
undetectable
1gtnF-4eowH:
undetectable
1gtnE-4eowH:
14.91
1gtnF-4eowH:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo
sapiens)
4 / 8 GLY H  33
ALA H  24
THR H  53
ILE H  34
None
0.71A 1gtnI-4eowH:
undetectable
1gtnJ-4eowH:
undetectable
1gtnI-4eowH:
14.91
1gtnJ-4eowH:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo
sapiens)
4 / 8 GLY H  33
ALA H  24
THR H  53
ILE H  34
None
0.73A 1utdI-4eowH:
undetectable
1utdJ-4eowH:
undetectable
1utdI-4eowH:
14.91
1utdJ-4eowH:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo
sapiens)
3 / 3 TYR H  32
LEU H  81
ARG H  99
None
0.80A 3sufB-4eowH:
undetectable
3sufB-4eowH:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo
sapiens)
3 / 3 ASP H 115
TYR H 109
TRP H 117
None
1.39A 4p7nA-4eowH:
undetectable
4p7nA-4eowH:
19.40