SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ep0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		4 / 4 ILE A 531
MET A 542
VAL A 120
GLY A 530
 None
 1.19A 1e06B-4ep0A:
undetectable		 1e06B-4ep0A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		4 / 8 VAL A 537
LEU A 545
PRO A 535
VAL A 120
 None
 1.08A 1jtvA-4ep0A:
undetectable		 1jtvA-4ep0A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		5 / 12 HIS A  22
GLY A 118
ASN A  24
ASP A 516
VAL A 120
 None
 1.32A 1qu3A-4ep0A:
undetectable		 1qu3A-4ep0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		4 / 6 ALA A 311
ILE A 328
VAL A 350
PHE A 334
 None
 0.84A 2cizA-4ep0A:
undetectable		 2cizA-4ep0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		3 / 3 ARG A  29
GLU A  27
GLN A 117
 None
 1.04A 2p16A-4ep0A:
0.9		 2p16A-4ep0A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		4 / 7 VAL A 553
ASP A 110
LEU A 548
ILE A 517
 None
 1.05A 3avpA-4ep0A:
undetectable		 3avpA-4ep0A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		4 / 8 GLU A 345
TYR A 349
PHE A 246
SER A 274
 None
 1.02A 3jz0B-4ep0A:
undetectable		 3jz0B-4ep0A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		5 / 11 LEU A 304
LEU A 303
GLY A 486
HIS A 161
LEU A 485
 None
 1.23A 3uudA-4ep0A:
undetectable		 3uudA-4ep0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		5 / 12 SER A 283
LEU A 284
ILE A 323
LEU A 313
VAL A 481
 None
 1.20A 3w68A-4ep0A:
undetectable		 3w68A-4ep0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		5 / 10 GLY A 294
ASP A 300
LEU A 295
ASN A 296
ILE A 308
 None
 1.16A 3wdmD-4ep0A:
undetectable		 3wdmD-4ep0A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		3 / 3 LYS A 343
THR A 339
ILE A 364
 None
 0.84A 4e0fB-4ep0A:
0.2		 4e0fB-4ep0A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		4 / 7 PHE A 168
ASN A 280
ILE A 346
PHE A 246
 None
 0.85A 4ejjA-4ep0A:
undetectable		 4ejjA-4ep0A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		5 / 12 ARG A  49
ILE A   6
LEU A  55
VAL A  57
ILE A  59
 None
 1.00A 4uw0A-4ep0A:
undetectable		 4uw0A-4ep0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		5 / 11 LEU A 304
LEU A 303
GLY A 486
HIS A 161
LEU A 485
 None
 1.23A 5dxbB-4ep0A:
undetectable		 5dxbB-4ep0A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		5 / 11 LEU A 304
LEU A 303
GLY A 486
HIS A 161
LEU A 485
 None
 1.20A 5dxgB-4ep0A:
undetectable		 5dxgB-4ep0A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		4 / 5 ARG A 487
MET A 290
THR A 292
LEU A 289
 None
 1.41A 5w97J-4ep0A:
undetectable		 5w97J-4ep0A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 4ep0 MAJOR TAIL PROTEIN
(Streptococcus
virus
C1) 		4 / 4 PHE A 334
ASP A 335
LEU A 332
LYS A 351
 None
 1.11A 6awvA-4ep0A:
undetectable		 6awvA-4ep0A:
14.76