SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ep5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4ep5 CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUVC
(Thermus
thermophilus) 		4 / 6 VAL A  17
GLY A  16
LEU A  15
GLU A  57
 None
 0.84A 1fduD-4ep5A:
2.5		 1fduD-4ep5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 4ep5 CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUVC
(Thermus
thermophilus) 		5 / 12 GLY A  33
LEU A  30
LEU A 133
VAL A 129
ALA A 147
 None
 1.25A 1gseA-4ep5A:
undetectable		 1gseA-4ep5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4ep5 CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUVC
(Thermus
thermophilus) 		4 / 5 ALA A 155
TYR A 157
ALA A 151
TYR A 105
 None
 1.14A 1xl6A-4ep5A:
undetectable
1xl6B-4ep5A:
undetectable		 1xl6A-4ep5A:
20.00
1xl6B-4ep5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4ep5 CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUVC
(Thermus
thermophilus) 		4 / 4 ALA A 155
TYR A 157
ALA A 151
TYR A 105
 None
 1.18A 2wlkA-4ep5A:
undetectable
2wlkB-4ep5A:
undetectable		 2wlkA-4ep5A:
20.00
2wlkB-4ep5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ep5 CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUVC
(Thermus
thermophilus) 		5 / 10 ILE A   6
ILE A 150
VAL A 110
GLY A 106
LEU A  88
 None
None
None
SO4  A 204 (-3.1A)
None
 1.27A 3em0A-4ep5A:
undetectable		 3em0A-4ep5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 4ep5 CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUVC
(Thermus
thermophilus) 		5 / 11 ALA A 149
GLY A  14
GLY A  16
ILE A 150
PRO A 141
 None
None
None
None
GOL  A 205 (-4.2A)
 1.00A 4dcmA-4ep5A:
undetectable		 4dcmA-4ep5A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4ep5 CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUVC
(Thermus
thermophilus) 		6 / 12 THR A 153
PHE A 156
TYR A 157
GLN A 112
LEU A 114
LEU A  26
 None
 1.47A 4g1bD-4ep5A:
undetectable		 4g1bD-4ep5A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4ep5 CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUVC
(Thermus
thermophilus) 		4 / 6 LEU A  59
VAL A  55
LEU A  15
VAL A  91
 None
 0.76A 5x7zA-4ep5A:
undetectable		 5x7zA-4ep5A:
25.00