SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ep6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		5 / 10 ALA A 504
GLY A 239
HIS A 245
THR A 384
THR A 236
 HEM  A 601 ( 3.7A)
None
HEM  A 601 (-3.8A)
None
None
 1.24A 1gtnH-4ep6A:
undetectable
1gtnI-4ep6A:
undetectable		 1gtnH-4ep6A:
11.92
1gtnI-4ep6A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		5 / 10 GLY A 239
HIS A 245
THR A 384
THR A 236
ALA A 504
 None
HEM  A 601 (-3.8A)
None
None
HEM  A 601 ( 3.7A)
 1.23A 1gtnO-4ep6A:
undetectable
1gtnP-4ep6A:
undetectable		 1gtnO-4ep6A:
11.92
1gtnP-4ep6A:
11.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		5 / 11 PHE A 388
ALA A 390
ALA A 337
ALA A 338
LEU A 344
 HEM  A 601 (-4.2A)
None
None
None
None
 0.97A 1jinA-4ep6A:
43.9		 1jinA-4ep6A:
30.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		5 / 9 ALA A 469
ASN A 470
TYR A 206
PHE A 441
GLY A 497
 None
None
None
HEM  A 601 (-4.4A)
HEM  A 601 (-4.1A)
 1.46A 1ru9H-4ep6A:
undetectable
1ru9L-4ep6A:
undetectable		 1ru9H-4ep6A:
19.62
1ru9L-4ep6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		5 / 10 ALA A 469
ASN A 470
TYR A 206
PHE A 441
GLY A 497
 None
None
None
HEM  A 601 (-4.4A)
HEM  A 601 (-4.1A)
 1.44A 1ruaH-4ep6A:
undetectable
1ruaL-4ep6A:
undetectable		 1ruaH-4ep6A:
19.62
1ruaL-4ep6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 6 ALA A 349
LEU A 352
ILE A 382
SER A 345
 None
 1.04A 1sbrA-4ep6A:
undetectable
1sbrB-4ep6A:
undetectable		 1sbrA-4ep6A:
19.74
1sbrB-4ep6A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 6 VAL A 348
LEU A 344
PHE A 341
MET A 318
 None
 1.11A 1x8vA-4ep6A:
30.1		 1x8vA-4ep6A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 5 PRO A 487
ALA A 490
ASP A 483
ASP A 477
 None
 1.02A 2nyuB-4ep6A:
undetectable		 2nyuB-4ep6A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 8 LEU A 344
SER A 345
ALA A 321
ALA A 337
 None
 1.03A 3ax9B-4ep6A:
1.8		 3ax9B-4ep6A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 7 ARG A 372
ASP A 369
ASP A 365
ARG A 356
 None
 1.46A 3kivA-4ep6A:
undetectable		 3kivA-4ep6A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 7 ARG A 523
ASP A 277
ASP A 274
ARG A 269
 None
 1.44A 3kivA-4ep6A:
undetectable		 3kivA-4ep6A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		5 / 12 ILE A 404
ALA A 292
LEU A 291
VAL A 272
LEU A 551
 None
 1.17A 3ozuA-4ep6A:
undetectable		 3ozuA-4ep6A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		3 / 3 PHE A 464
TYR A 201
LEU A 439
 None
 0.71A 3sueB-4ep6A:
undetectable		 3sueB-4ep6A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 7 ILE A 404
GLU A 522
LEU A 276
VAL A 272
 None
 0.86A 3ua5B-4ep6A:
30.7		 3ua5B-4ep6A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 7 ILE A 527
GLU A 522
LEU A 276
VAL A 272
 None
 0.74A 3ua5B-4ep6A:
30.7		 3ua5B-4ep6A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		3 / 3 GLU A 430
ASP A 483
ASP A 480
 None
 0.69A 4gc9A-4ep6A:
undetectable		 4gc9A-4ep6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		3 / 3 ASN A 538
ALA A 541
ARG A 543
 None
 0.79A 5cvtB-4ep6A:
undetectable		 5cvtB-4ep6A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 7 ASN A 429
VAL A 432
GLY A 497
ARG A 510
 None
None
HEM  A 601 (-4.1A)
None
 0.87A 5fpdA-4ep6A:
undetectable		 5fpdA-4ep6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 7 ILE A 396
GLY A 397
PHE A 540
PHE A 441
 HEM  A 601 (-3.9A)
None
None
HEM  A 601 (-4.4A)
 1.01A 5hieA-4ep6A:
undetectable		 5hieA-4ep6A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 4 SER A 240
ALA A 237
GLN A 251
THR A 384
 None
HEM  A 601 (-3.1A)
None
None
 1.28A 5n0rA-4ep6A:
undetectable		 5n0rA-4ep6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 4 SER A 240
ALA A 237
GLN A 251
THR A 384
 None
HEM  A 601 (-3.1A)
None
None
 1.27A 5n0sA-4ep6A:
undetectable		 5n0sA-4ep6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 5 SER A 240
ALA A 237
GLN A 251
THR A 384
 None
HEM  A 601 (-3.1A)
None
None
 1.28A 5n0tA-4ep6A:
undetectable		 5n0tA-4ep6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 4 SER A 240
ALA A 237
GLN A 251
THR A 384
 None
HEM  A 601 (-3.1A)
None
None
 1.28A 5n0wA-4ep6A:
undetectable		 5n0wA-4ep6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 5 SER A 240
ALA A 237
GLN A 251
THR A 384
 None
HEM  A 601 (-3.1A)
None
None
 1.28A 5n0wB-4ep6A:
undetectable		 5n0wB-4ep6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 4 SER A 240
ALA A 237
GLN A 251
THR A 384
 None
HEM  A 601 (-3.1A)
None
None
 1.29A 5n0xA-4ep6A:
undetectable		 5n0xA-4ep6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 5 SER A 240
ALA A 237
GLN A 251
THR A 384
 None
HEM  A 601 (-3.1A)
None
None
 1.30A 5n4iA-4ep6A:
undetectable		 5n4iA-4ep6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		4 / 5 TYR A 184
ASP A 472
PRO A 473
ALA A 469
 None
 1.02A 5otrA-4ep6A:
undetectable		 5otrA-4ep6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA
(Rhodococcus
rhodochrous) 		5 / 10 PHE A 388
LEU A 363
ALA A 364
LEU A 306
GLU A 353
 HEM  A 601 (-4.2A)
None
None
None
None
 1.17A 5y7pG-4ep6A:
undetectable		 5y7pG-4ep6A:
18.86