SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4epa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 ALA A 468
VAL A 470
TRP A 513
None
0.76A 1av2A-4epaA:
undetectable
1av2B-4epaA:
undetectable
1av2A-4epaA:
2.15
1av2B-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 TRP A 513
ALA A 468
VAL A 470
None
0.86A 1av2C-4epaA:
undetectable
1av2D-4epaA:
undetectable
1av2C-4epaA:
2.15
1av2D-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 ALA A 572
VAL A 556
TRP A 521
None
0.88A 1c4dC-4epaA:
undetectable
1c4dD-4epaA:
undetectable
1c4dC-4epaA:
2.15
1c4dD-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 TRP A 513
ALA A 468
VAL A 470
None
0.90A 1c4dC-4epaA:
undetectable
1c4dD-4epaA:
undetectable
1c4dC-4epaA:
2.15
1c4dD-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 TRP A 521
ALA A 572
VAL A 556
None
0.73A 1c4dC-4epaA:
undetectable
1c4dD-4epaA:
undetectable
1c4dC-4epaA:
2.15
1c4dD-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 12 LEU A 335
SER A 337
TYR A  80
ILE A 440
PHE A  79
None
1.33A 1fmlA-4epaA:
undetectable
1fmlA-4epaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
4 / 7 ASP A 363
LEU A 111
SER A  15
SER A  18
None
1.24A 1ig3A-4epaA:
undetectable
1ig3B-4epaA:
undetectable
1ig3A-4epaA:
20.09
1ig3B-4epaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 12 LEU A  55
VAL A 105
LEU A 102
LEU A  37
LEU A 110
None
0.80A 1mx1C-4epaA:
undetectable
1mx1C-4epaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 12 LEU A  55
VAL A 105
LEU A 102
LEU A  37
LEU A 110
None
0.86A 1mx1D-4epaA:
undetectable
1mx1D-4epaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 ARG A 176
ASP A 192
ASN A 185
None
0.79A 1nbhA-4epaA:
undetectable
1nbhA-4epaA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 ARG A 176
ASP A 192
ASN A 185
None
0.76A 1nbhD-4epaA:
undetectable
1nbhD-4epaA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 12 ILE A 528
GLY A 577
VAL A 547
ALA A 593
GLY A  54
None
1.10A 1nbiA-4epaA:
undetectable
1nbiA-4epaA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 12 ILE A 528
GLY A 577
VAL A 547
ALA A 593
GLY A  54
None
1.11A 1nbiB-4epaA:
undetectable
1nbiB-4epaA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
4 / 8 ARG A 622
ASN A 628
SER A 631
VAL A 633
None
1.30A 1u1jA-4epaA:
undetectable
1u1jA-4epaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 ALA A 468
VAL A 470
TRP A 513
None
0.74A 1w5uA-4epaA:
undetectable
1w5uB-4epaA:
undetectable
1w5uA-4epaA:
2.15
1w5uB-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 TRP A 513
ALA A 468
VAL A 470
None
0.81A 1w5uA-4epaA:
undetectable
1w5uB-4epaA:
undetectable
1w5uA-4epaA:
2.15
1w5uB-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 ALA A 468
VAL A 470
TRP A 513
None
0.95A 2izqA-4epaA:
undetectable
2izqB-4epaA:
undetectable
2izqA-4epaA:
2.15
2izqB-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 TRP A 513
ALA A 468
VAL A 470
None
0.79A 2izqC-4epaA:
undetectable
2izqD-4epaA:
undetectable
2izqC-4epaA:
2.15
2izqD-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 THR A  43
ASP A 596
SER A 555
None
0.80A 2nxeA-4epaA:
undetectable
2nxeA-4epaA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 THR A 623
ASP A 230
SER A 291
None
0.61A 2nxeA-4epaA:
undetectable
2nxeA-4epaA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 THR A  43
ASP A 596
SER A 555
None
0.82A 2nxeB-4epaA:
undetectable
2nxeB-4epaA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 THR A 623
ASP A 230
SER A 291
None
0.59A 2nxeB-4epaA:
undetectable
2nxeB-4epaA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 SER A 160
ASP A 165
ASP A 136
None
0.70A 2plwA-4epaA:
undetectable
2plwA-4epaA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
4 / 7 ALA A 359
TYR A 327
ASP A 383
TYR A 433
None
1.29A 2pncA-4epaA:
undetectable
2pncA-4epaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 10 VAL A 547
ILE A 528
LEU A 110
ARG A 112
GLY A 113
None
1.26A 2xf3A-4epaA:
0.6
2xf3A-4epaA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 9 VAL A 547
ILE A 528
LEU A 110
ARG A 112
GLY A 113
None
1.26A 2xf3B-4epaA:
0.9
2xf3B-4epaA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
4 / 8 THR A 357
ASP A 383
SER A 381
TYR A 361
None
1.12A 2xz5A-4epaA:
undetectable
2xz5C-4epaA:
undetectable
2xz5A-4epaA:
16.49
2xz5C-4epaA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
4 / 8 THR A 357
ASP A 383
SER A 381
TYR A 361
None
1.11A 2xz5C-4epaA:
undetectable
2xz5D-4epaA:
undetectable
2xz5C-4epaA:
16.49
2xz5D-4epaA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 GLY A 432
GLY A 120
GLY A 116
None
0.43A 3bogC-4epaA:
undetectable
3bogC-4epaA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 GLY A 432
GLY A 120
GLY A 116
None
0.42A 3bogD-4epaA:
undetectable
3bogD-4epaA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 12 ASP A 363
GLY A 377
VAL A 323
LEU A 413
ALA A  22
None
1.28A 3d91B-4epaA:
undetectable
3d91B-4epaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 12 ILE A 200
LEU A 174
ASN A 158
THR A 132
THR A 103
None
1.22A 3dcjA-4epaA:
undetectable
3dcjB-4epaA:
undetectable
3dcjA-4epaA:
18.54
3dcjB-4epaA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 TRP A 513
ALA A 468
VAL A 470
None
0.85A 3l8lC-4epaA:
undetectable
3l8lD-4epaA:
undetectable
3l8lC-4epaA:
2.15
3l8lD-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
3 / 3 LEU A 538
MET A 484
ASP A  78
None
0.77A 3v5wA-4epaA:
undetectable
3v5wA-4epaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
4 / 8 VAL A 636
TYR A 232
TYR A 624
LEU A 587
None
1.06A 3v81A-4epaA:
undetectable
3v81A-4epaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1480_0
(MJ0495-LIKE PROTEIN)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
4 / 4 LYS A 266
GLU A 308
ILE A 277
SER A 264
None
1.45A 4ac9C-4epaA:
0.0
4ac9C-4epaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
4 / 4 LYS A 266
GLU A 308
ILE A 277
SER A 264
None
1.44A 4acaC-4epaA:
0.0
4acaC-4epaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
4 / 4 LYS A 266
GLU A 308
ILE A 277
SER A 264
None
1.50A 4acbC-4epaA:
0.0
4acbC-4epaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 12 GLY A 625
TYR A 232
GLY A  61
SER A  60
GLY A 583
None
1.19A 4blvB-4epaA:
undetectable
4blvB-4epaA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
4 / 8 ALA A 123
SER A 122
ARG A 379
TYR A 433
None
1.16A 4ijiF-4epaA:
undetectable
4ijiF-4epaA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 12 PRO A 548
TYR A 580
ALA A  76
ASN A 585
GLY A 583
None
1.07A 4oaeA-4epaA:
undetectable
4oaeA-4epaA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 12 ASN A 458
ALA A 123
GLU A 508
GLU A 460
LEU A 110
None
1.24A 4zjoA-4epaA:
undetectable
4zjoA-4epaA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 12 GLY A 116
TYR A 433
ALA A 453
SER A  95
TYR A  87
None
1.22A 5igvA-4epaA:
undetectable
5igvA-4epaA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
4 / 8 PHE A 581
ARG A 549
GLN A 589
GLY A 577
None
0.93A 5nzxA-4epaA:
undetectable
5nzxA-4epaA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 9 LEU A  52
VAL A  31
ILE A 127
LEU A  70
ALA A  14
None
1.15A 5og9A-4epaA:
undetectable
5og9A-4epaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)
4epa PESTICIN RECEPTOR
(Yersinia
pestis)
5 / 12 LEU A  52
VAL A  31
ILE A 127
LEU A  70
ALA A  14
None
1.18A 5og9B-4epaA:
undetectable
5og9B-4epaA:
21.77