SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4epc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 4epc N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Staphylococcus
epidermidis) 		3 / 3 TRP A 839
ALA A 804
VAL A 795
 MLY  A 819 ( 4.9A)
None
None
 0.99A 3l8lA-4epcA:
undetectable
3l8lB-4epcA:
undetectable		 3l8lA-4epcA:
3.86
3l8lB-4epcA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4epc N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Staphylococcus
epidermidis) 		4 / 8 THR A 719
TRP A 763
ASP A 723
TYR A 722
 None
 0.89A 4drjB-4epcA:
undetectable		 4drjB-4epcA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4epc N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Staphylococcus
epidermidis) 		4 / 7 LYS A 741
TRP A 763
TYR A 771
VAL A 752
 MLY  A 740 ( 3.4A)
None
None
None
 1.46A 4l64A-4epcA:
undetectable		 4l64A-4epcA:
19.12