SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4epi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4epi PESTICIN, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Yersinia
pestis) 		5 / 11 GLU A  78
VAL A 147
ILE A 148
LEU A 124
LEU A 160
 None
 1.35A 1mrqA-4epiA:
undetectable		 1mrqA-4epiA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4epi PESTICIN, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Yersinia
pestis) 		5 / 12 ALA A 294
PHE A 318
LEU A 298
ALA A 295
ILE A 243
 None
 1.03A 2aclA-4epiA:
undetectable
2aclE-4epiA:
undetectable		 2aclA-4epiA:
20.83
2aclE-4epiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4epi PESTICIN, LYSOZYME
CHIMERA
(Yersinia
pestis;
Escherichia
virus
T4) 		5 / 10 THR A  95
VAL A 110
VAL A 147
ILE A 140
VAL A 141
 None
 1.38A 2qboA-4epiA:
undetectable		 2qboA-4epiA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4epi PESTICIN, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Yersinia
pestis) 		4 / 8 THR A 199
TYR A 190
ILE A 182
SER A 201
 None
 1.11A 2xytE-4epiA:
undetectable		 2xytE-4epiA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4epi PESTICIN, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Yersinia
pestis) 		4 / 8 THR A 199
TYR A 190
ILE A 182
SER A 201
 None
 1.05A 2xytH-4epiA:
undetectable		 2xytH-4epiA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4epi PESTICIN, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Yersinia
pestis) 		4 / 7 THR A 199
TYR A 190
ILE A 182
SER A 201
 None
 1.09A 2xytI-4epiA:
undetectable		 2xytI-4epiA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4epi PESTICIN, LYSOZYME
CHIMERA
(Yersinia
pestis;
Escherichia
virus
T4) 		4 / 7 THR A 317
TRP A 323
LEU A 172
PHE A 318
 None
 1.38A 4awuA-4epiA:
undetectable		 4awuA-4epiA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4epi PESTICIN, LYSOZYME
CHIMERA
(Yersinia
pestis;
Escherichia
virus
T4) 		4 / 7 PHE A 269
ILE A 265
TYR A 253
ASN A 233
 None
 1.27A 4o7gA-4epiA:
undetectable
4o7gB-4epiA:
undetectable		 4o7gA-4epiA:
20.11
4o7gB-4epiA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4epi PESTICIN, LYSOZYME
CHIMERA
(Yersinia
pestis;
Escherichia
virus
T4) 		4 / 5 ILE A  81
PHE A 159
ARG A 139
THR A  95
 None
 1.27A 5z84N-4epiA:
undetectable
5z84W-4epiA:
undetectable		 5z84N-4epiA:
20.60
5z84W-4epiA:
13.42