SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4epp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 ILE A  91
LEU A  78
PHE A  86
ILE A 169
LEU A  71
 None
 1.13A 1ddrB-4eppA:
undetectable		 1ddrB-4eppA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 ILE A  91
LEU A  78
PHE A  86
ILE A 169
LEU A  71
 None
 1.13A 1dyiA-4eppA:
undetectable		 1dyiA-4eppA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 ILE A  91
LEU A  78
PHE A  86
ILE A 169
LEU A  71
 None
 1.13A 1dyiB-4eppA:
undetectable		 1dyiB-4eppA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 11 VAL A 208
GLU A 202
ILE A 384
VAL A 426
MET A 427
 None
 1.25A 1gx9A-4eppA:
1.1		 1gx9A-4eppA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		4 / 6 ILE A 287
GLU A 355
ARG A 258
LEU A 234
 None
 1.02A 1mt1B-4eppA:
undetectable
1mt1C-4eppA:
undetectable		 1mt1B-4eppA:
13.79
1mt1C-4eppA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 11 THR A 403
LEU A 444
VAL A 426
PHE A 422
VAL A 410
 None
 1.37A 1q23J-4eppA:
undetectable		 1q23J-4eppA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 ILE A  91
LEU A  78
PHE A  86
ILE A 169
LEU A  71
 None
 1.13A 1rx8A-4eppA:
undetectable		 1rx8A-4eppA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 ILE A  91
LEU A  78
PHE A  86
ILE A 169
LEU A  71
 None
 1.16A 1tdrA-4eppA:
undetectable		 1tdrA-4eppA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		3 / 3 ARG A 388
TYR A 349
LYS A 353
 None
 0.89A 1uujB-4eppA:
undetectable		 1uujB-4eppA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		3 / 3 LEU A 266
PHE A 259
ARG A 195
 None
 0.71A 1xdkF-4eppA:
undetectable		 1xdkF-4eppA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		3 / 3 ARG A  58
SER A  60
TYR A  68
 None
 0.79A 2q2hA-4eppA:
undetectable
2q2hB-4eppA:
undetectable		 2q2hA-4eppA:
14.69
2q2hB-4eppA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 11 ILE A 324
ALA A 326
GLU A 344
ILE A 395
VAL A 236
 None
APR  A 501 ( 4.6A)
None
None
None
 1.12A 2w3aA-4eppA:
undetectable		 2w3aA-4eppA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		4 / 8 ILE A  94
PHE A  86
LEU A  54
LEU A  50
 None
 0.81A 2w98B-4eppA:
undetectable		 2w98B-4eppA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 11 LEU A 447
PHE A 422
LEU A 425
TYR A 443
GLU A 450
 None
 1.43A 3bgrA-4eppA:
0.1
3bgrB-4eppA:
undetectable		 3bgrA-4eppA:
22.86
3bgrB-4eppA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 ILE A 196
ILE A 324
SER A 348
LEU A 234
ILE A 283
 None
 1.04A 3cd2A-4eppA:
undetectable		 3cd2A-4eppA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		4 / 7 GLN A 335
GLY A 367
GLY A 373
ALA A 326
 None
APR  A 501 (-2.9A)
None
APR  A 501 ( 4.6A)
 0.79A 3fpjB-4eppA:
undetectable		 3fpjB-4eppA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 ASP A 400
THR A 363
ILE A 395
MET A 393
GLN A 382
 None
 1.29A 3g4lD-4eppA:
undetectable		 3g4lD-4eppA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		4 / 7 TYR A 293
VAL A 261
ILE A 227
THR A 233
 None
None
APR  A 501 (-3.9A)
None
 0.99A 3gssA-4eppA:
undetectable		 3gssA-4eppA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 LEU A  78
GLN A  83
PHE A  86
ILE A 169
LEU A  71
 None
 1.11A 3ia4C-4eppA:
undetectable		 3ia4C-4eppA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 11 LEU A 447
VAL A 410
LEU A 425
TYR A 443
GLU A 450
 None
 1.50A 3m8pA-4eppA:
undetectable
3m8pB-4eppA:
undetectable		 3m8pA-4eppA:
23.60
3m8pB-4eppA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 11 ILE A 324
ALA A 326
GLU A 344
ILE A 395
VAL A 236
 None
APR  A 501 ( 4.6A)
None
None
None
 1.13A 3n0hA-4eppA:
undetectable		 3n0hA-4eppA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 ILE A  91
LEU A  78
PHE A  86
ILE A 169
LEU A  71
 None
 1.17A 3ql0A-4eppA:
undetectable		 3ql0A-4eppA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 ILE A 324
ALA A 326
GLU A 344
ILE A 395
VAL A 236
 None
APR  A 501 ( 4.6A)
None
None
None
 1.11A 3s3vA-4eppA:
undetectable		 3s3vA-4eppA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		4 / 8 PHE A 238
SER A 362
ASP A 223
ASP A 224
 APR  A 501 (-4.7A)
None
None
None
 1.32A 4qb9D-4eppA:
undetectable		 4qb9D-4eppA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 11 ILE A  91
LEU A  78
PHE A  86
ILE A 169
LEU A  71
 None
 1.18A 4qlfA-4eppA:
undetectable		 4qlfA-4eppA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 ILE A  91
LEU A  78
PHE A  86
ILE A 169
LEU A  71
 None
 1.16A 4qlgA-4eppA:
undetectable		 4qlgA-4eppA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		4 / 7 ASN A 431
PRO A 430
PHE A 336
TYR A 204
 None
 1.41A 4v2yC-4eppA:
undetectable		 4v2yC-4eppA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 431
PRO A 430
PHE A 336
TYR A 204
 None
 1.44A 4v2zC-4eppA:
undetectable		 4v2zC-4eppA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 ILE A  91
LEU A  78
PHE A  86
ILE A 169
LEU A  71
 None
 1.10A 4x5hA-4eppA:
undetectable		 4x5hA-4eppA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 LEU A 447
VAL A 410
PHE A 422
LEU A 425
TYR A 443
 None
 1.50A 5cyqA-4eppA:
undetectable		 5cyqA-4eppA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		5 / 12 ILE A  91
LEU A  78
PHE A  86
ILE A 169
LEU A  71
 None
 1.16A 5e8qB-4eppA:
undetectable		 5e8qB-4eppA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		4 / 5 ILE A 161
GLN A 166
ARG A 165
GLU A 167
 None
 1.07A 5fseC-4eppA:
2.6		 5fseC-4eppA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		4 / 6 PHE A 352
CYH A 396
THR A 222
PHE A 230
 None
APR  A 501 (-4.2A)
None
None
 1.42A 5mwyA-4eppA:
undetectable		 5mwyA-4eppA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Tetrahymena
thermophila) 		4 / 6 PHE A 230
PRO A 231
GLY A 232
THR A 233
 None
 0.63A 5x24A-4eppA:
undetectable		 5x24A-4eppA:
22.54