SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		5 / 12 GLY A 517
GLY A 519
GLY A 520
GLY A 459
ASN A 406
 None
GOL  A 615 ( 4.0A)
None
None
SO4  A 607 ( 4.6A)
 0.89A 1n2xB-4epsA:
undetectable		 1n2xB-4epsA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 5 ASP A 217
VAL A 216
SER A 215
ASP A 315
 None
None
GOL  A 614 ( 4.1A)
GOL  A 613 (-3.4A)
 1.49A 1n2xB-4epsA:
undetectable		 1n2xB-4epsA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 5 GLY A 302
ILE A 449
VAL A 216
SER A 448
 None
 1.00A 1rs7A-4epsA:
undetectable		 1rs7A-4epsA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 6 GLY A 302
ILE A 449
VAL A 216
SER A 448
 None
 0.94A 1rs7B-4epsA:
undetectable		 1rs7B-4epsA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		5 / 12 GLY A  98
ILE A  84
GLY A  71
ILE A  70
ILE A 101
 GOL  A 626 (-4.3A)
None
None
None
GOL  A 626 (-4.6A)
 0.90A 2b60A-4epsA:
undetectable		 2b60A-4epsA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		3 / 3 ASN A 476
TYR A 509
SER A 470
 None
 0.65A 2gvcB-4epsA:
undetectable		 2gvcB-4epsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		3 / 3 ASN A 476
TYR A 509
SER A 470
 None
 0.65A 2gvcE-4epsA:
undetectable		 2gvcE-4epsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		5 / 12 PHE A 434
LEU A 420
VAL A 419
CYH A 433
HIS A 379
 GOL  A 618 ( 3.6A)
GOL  A 611 (-3.8A)
None
GOL  A 611 ( 3.7A)
None
 1.40A 2hc4A-4epsA:
undetectable		 2hc4A-4epsA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 7 ASP A 488
SER A 490
SER A 510
ASP A 466
 GOL  A 627 ( 4.7A)
None
CL  A 604 ( 4.5A)
None
 1.32A 3bc9A-4epsA:
undetectable		 3bc9A-4epsA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 7 GLY A 519
GLY A 520
TYR A 526
ASN A 524
 GOL  A 615 ( 4.0A)
None
GOL  A 621 ( 4.7A)
GOL  A 621 (-3.8A)
 0.88A 4fgkB-4epsA:
undetectable		 4fgkB-4epsA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 6 GLY A 302
ILE A 449
VAL A 216
SER A 448
 None
 1.02A 4kcnA-4epsA:
undetectable		 4kcnA-4epsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 6 TYR A 509
GLY A 459
SER A 458
LEU A 461
 None
 1.21A 5bphA-4epsA:
undetectable		 5bphA-4epsA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 4 TYR A 153
GLY A 274
SER A 184
LEU A 185
 GOL  A 608 ( 3.9A)
None
None
None
 1.31A 5bphC-4epsA:
undetectable		 5bphC-4epsA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 4 TYR A 509
GLY A 459
SER A 458
LEU A 461
 None
 1.22A 5bphC-4epsA:
undetectable		 5bphC-4epsA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 6 TYR A 509
GLY A 459
SER A 458
LEU A 461
 None
 1.26A 5bphD-4epsA:
undetectable		 5bphD-4epsA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 8 TRP A 141
PHE A 134
HIS A 181
THR A  90
 GOL  A 610 (-3.9A)
None
None
None
 1.33A 5hqaA-4epsA:
undetectable		 5hqaA-4epsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		5 / 12 PHE A 530
GLY A 533
GLY A 452
VAL A 360
LEU A 359
 None
None
GOL  A 625 (-3.8A)
None
None
 1.01A 5kocB-4epsA:
undetectable		 5kocB-4epsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 8 LEU A 137
MET A 122
ASN A  86
ILE A  70
 None
None
GOL  A 629 (-3.8A)
None
 0.94A 5mzjA-4epsA:
undetectable		 5mzjA-4epsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 7 LEU A 471
PHE A 531
THR A 365
THR A 527
 None
None
GOL  A 627 ( 4.1A)
None
 0.72A 6a7jA-4epsA:
undetectable		 6a7jA-4epsA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 4eps HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 5 GLU A 241
VAL A 187
LEU A 185
HIS A 181
 None
 1.41A 6dyoA-4epsA:
undetectable		 6dyoA-4epsA:
8.98