SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4epu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4epu ANGIOPOIETIN-1
(Homo
sapiens) 		4 / 6 TRP A 356
TRP A 448
ASN A 458
PRO A 454
 None
 1.21A 1dedA-4epuA:
undetectable		 1dedA-4epuA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4epu ANGIOPOIETIN-1
(Homo
sapiens) 		5 / 11 LEU A 373
PRO A 454
TRP A 448
LEU A 418
TYR A 389
 None
 1.40A 1klmA-4epuA:
undetectable		 1klmA-4epuA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4epu ANGIOPOIETIN-1
(Homo
sapiens) 		4 / 7 PHE A 337
GLY A 459
GLY A 333
PHE A 425
 None
 0.84A 3ko0M-4epuA:
undetectable
3ko0P-4epuA:
undetectable		 3ko0M-4epuA:
16.11
3ko0P-4epuA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4epu ANGIOPOIETIN-1
(Homo
sapiens) 		5 / 12 GLU A 343
GLY A 446
ALA A 430
ASP A 433
PHE A 449
 None
None
None
CA  A 601 (-2.7A)
None
 1.32A 3qowA-4epuA:
undetectable		 3qowA-4epuA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4epu ANGIOPOIETIN-1
(Homo
sapiens) 		3 / 3 TYR A 404
ASP A 424
ASP A 450
 None
 0.69A 4a6eA-4epuA:
undetectable		 4a6eA-4epuA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4epu ANGIOPOIETIN-1
(Homo
sapiens) 		4 / 7 PHE A 348
TYR A 344
TRP A 356
PHE A 425
 None
 1.23A 4grqA-4epuA:
undetectable
4grqC-4epuA:
undetectable		 4grqA-4epuA:
17.54
4grqC-4epuA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4epu ANGIOPOIETIN-1
(Homo
sapiens) 		4 / 7 TYR A 344
GLN A 328
TRP A 356
PHE A 425
 None
 1.45A 4grqA-4epuA:
undetectable
4grqC-4epuA:
undetectable		 4grqA-4epuA:
17.54
4grqC-4epuA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4epu ANGIOPOIETIN-1
(Homo
sapiens) 		4 / 8 SER A 297
ASP A 318
MET A 491
VAL A 326
 None
 1.16A 4lnwA-4epuA:
undetectable		 4lnwA-4epuA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 4epu ANGIOPOIETIN-1
(Homo
sapiens) 		5 / 12 GLY A 333
GLU A 354
ASN A 472
SER A 485
ILE A 474
 None
 1.20A 4pb1A-4epuA:
undetectable		 4pb1A-4epuA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4epu ANGIOPOIETIN-1
(Homo
sapiens) 		5 / 12 GLY A 446
GLY A 445
THR A 444
GLN A 328
PHE A 348
 None
 1.14A 4zvmA-4epuA:
undetectable
4zvmB-4epuA:
undetectable		 4zvmA-4epuA:
19.68
4zvmB-4epuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 4epu ANGIOPOIETIN-1
(Homo
sapiens) 		4 / 7 GLY A 469
TRP A 380
MET A 460
TYR A 462
 None
 1.43A 6ag0C-4epuA:
undetectable		 6ag0C-4epuA:
16.75