SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4epz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4epz TRANSCRIPTION
ANTI-TERMINATOR
ANTAGONIST UPXZ
(Bacteroides
uniformis) 		4 / 5 LEU A  97
LEU A 102
LEU A   9
GLY A  59
 None
 1.02A 1a4lC-4epzA:
undetectable		 1a4lC-4epzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4epz TRANSCRIPTION
ANTI-TERMINATOR
ANTAGONIST UPXZ
(Bacteroides
uniformis) 		4 / 7 ILE A  93
GLU A 122
LEU A 107
GLY A  59
 None
 0.84A 1mt1H-4epzA:
undetectable
1mt1K-4epzA:
undetectable		 1mt1H-4epzA:
20.75
1mt1K-4epzA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4epz TRANSCRIPTION
ANTI-TERMINATOR
ANTAGONIST UPXZ
(Bacteroides
uniformis) 		4 / 8 ILE A  93
GLU A 122
LEU A 107
GLY A  59
 None
 0.90A 2qqdB-4epzA:
undetectable
2qqdC-4epzA:
undetectable		 2qqdB-4epzA:
21.38
2qqdC-4epzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 4epz TRANSCRIPTION
ANTI-TERMINATOR
ANTAGONIST UPXZ
(Bacteroides
uniformis) 		4 / 7 LYS A  79
GLY A  68
SER A  44
LEU A  41
 None
 1.06A 5bphB-4epzA:
undetectable		 5bphB-4epzA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4epz TRANSCRIPTION
ANTI-TERMINATOR
ANTAGONIST UPXZ
(Bacteroides
uniformis) 		4 / 6 GLU A 117
PHE A 149
THR A 108
TYR A 111
 None
 1.15A 5lrbA-4epzA:
undetectable		 5lrbA-4epzA:
11.65