SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eq9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ASP A  94
LEU A  93
PHE A  90
THR A 108
LEU A 105
 None
None
None
None
GSH  A 301 (-4.7A)
 1.12A 1dyiA-4eq9A:
undetectable		 1dyiA-4eq9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ASP A  94
LEU A  93
PHE A  90
THR A 108
LEU A 105
 None
None
None
None
GSH  A 301 (-4.7A)
 1.09A 1dyiB-4eq9A:
undetectable		 1dyiB-4eq9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 7 TYR A 229
ILE A 275
PRO A 270
ALA A 122
 None
 1.13A 1oniD-4eq9A:
undetectable
1oniE-4eq9A:
undetectable		 1oniD-4eq9A:
18.26
1oniE-4eq9A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ASP A  94
LEU A  93
PHE A  90
THR A 108
LEU A 105
 None
None
None
None
GSH  A 301 (-4.7A)
 1.13A 1tdrA-4eq9A:
undetectable		 1tdrA-4eq9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 5 PRO A 230
VAL A 102
VAL A  67
ILE A 121
 None
 0.94A 1z2bC-4eq9A:
undetectable		 1z2bC-4eq9A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 8 ASN A 103
GLY A  46
ASN A  45
ILE A 184
 GSH  A 301 (-4.2A)
None
GSH  A 301 (-3.3A)
GSH  A 301 (-4.6A)
 0.83A 2yoeB-4eq9A:
undetectable
2yoeC-4eq9A:
undetectable		 2yoeB-4eq9A:
19.29
2yoeC-4eq9A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 4 LEU A 256
ALA A 122
VAL A 228
PRO A 120
 None
 1.03A 3gv1B-4eq9A:
undetectable		 3gv1B-4eq9A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 7 VAL A 102
PHE A  81
VAL A  79
ILE A 247
 None
 0.99A 3zjqA-4eq9A:
undetectable		 3zjqA-4eq9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 8 ASP A 141
ASP A 142
VAL A 130
LEU A 220
 None
 0.80A 4f8hA-4eq9A:
undetectable
4f8hB-4eq9A:
undetectable		 4f8hA-4eq9A:
20.69
4f8hB-4eq9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 8 ASP A 141
ASP A 142
VAL A 130
LEU A 220
 None
 0.88A 4f8hB-4eq9A:
undetectable
4f8hC-4eq9A:
undetectable		 4f8hB-4eq9A:
20.69
4f8hC-4eq9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 8 ASP A 141
ASP A 142
VAL A 130
LEU A 220
 None
 0.82A 4f8hC-4eq9A:
undetectable
4f8hD-4eq9A:
undetectable		 4f8hC-4eq9A:
20.69
4f8hD-4eq9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 8 ASP A 141
ASP A 142
VAL A 130
LEU A 220
 None
 0.82A 4f8hD-4eq9A:
undetectable
4f8hE-4eq9A:
undetectable		 4f8hD-4eq9A:
20.69
4f8hE-4eq9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 8 VAL A 130
LEU A 220
ASP A 141
ASP A 142
 None
 0.83A 4f8hA-4eq9A:
undetectable
4f8hE-4eq9A:
undetectable		 4f8hA-4eq9A:
20.69
4f8hE-4eq9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ASP A  94
LEU A  93
PHE A  90
THR A 108
LEU A 105
 None
None
None
None
GSH  A 301 (-4.7A)
 1.11A 4qleA-4eq9A:
undetectable		 4qleA-4eq9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 6 SER A 139
LEU A 140
ASP A 141
LEU A 128
 None
 0.98A 4wozA-4eq9A:
undetectable
4wozB-4eq9A:
undetectable		 4wozA-4eq9A:
21.94
4wozB-4eq9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ASP A  94
LEU A  93
PHE A  90
THR A 108
LEU A 105
 None
None
None
None
GSH  A 301 (-4.7A)
 1.09A 4x5gA-4eq9A:
undetectable		 4x5gA-4eq9A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		3 / 3 LYS A  83
ASN A  45
SER A  47
 None
GSH  A 301 (-3.3A)
None
 1.28A 5yw0A-4eq9A:
undetectable		 5yw0A-4eq9A:
21.02