SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eqf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		4 / 8 TYR A 239
ARG A 236
TYR A 224
GLU A  67
 None
 1.20A 1nx9A-4eqfA:
undetectable		 1nx9A-4eqfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		4 / 8 TYR A 239
ARG A 236
TYR A 224
GLU A  67
 None
 1.19A 1nx9B-4eqfA:
undetectable		 1nx9B-4eqfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		4 / 8 TYR A 239
ARG A 236
TYR A 224
GLU A  67
 None
 1.19A 1nx9C-4eqfA:
undetectable		 1nx9C-4eqfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		4 / 8 TYR A 239
ARG A 236
TYR A 224
GLU A  67
 None
 1.20A 1nx9D-4eqfA:
undetectable		 1nx9D-4eqfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		5 / 12 PHE A 183
GLY A 181
GLY A 174
LEU A 179
ASP A 188
 None
 1.01A 2nxeB-4eqfA:
undetectable		 2nxeB-4eqfA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		5 / 10 SER A 237
TYR A 224
ALA A 227
ASN A 205
ALA A 223
 None
 1.38A 2r2vC-4eqfA:
undetectable
2r2vF-4eqfA:
undetectable
2r2vG-4eqfA:
undetectable		 2r2vC-4eqfA:
9.42
2r2vF-4eqfA:
9.42
2r2vG-4eqfA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		5 / 12 PHE A 183
GLY A 181
GLY A 174
LEU A 179
ASP A 188
 None
 0.96A 2zbpA-4eqfA:
undetectable		 2zbpA-4eqfA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		4 / 7 GLU A  69
ARG A 236
GLU A  67
SER A 280
 None
 1.25A 2zt7A-4eqfA:
undetectable		 2zt7A-4eqfA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		4 / 5 PHE A 258
TYR A 251
LEU A 312
ARG A 252
 None
 1.32A 3sudD-4eqfA:
undetectable		 3sudD-4eqfA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		5 / 12 PHE A  10
GLY A  26
LEU A  30
PHE A  23
ALA A  55
 None
 1.13A 3tbgB-4eqfA:
undetectable		 3tbgB-4eqfA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		5 / 12 PHE A  10
GLY A  26
LEU A  30
PHE A  23
ALA A  55
 None
 1.12A 3tbgD-4eqfA:
undetectable		 3tbgD-4eqfA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		5 / 10 LEU A 203
TRP A 113
ALA A 106
ALA A  92
GLY A 172
 None
 1.17A 4rn6A-4eqfA:
undetectable		 4rn6A-4eqfA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		5 / 12 PRO A 232
GLY A 233
LEU A  27
ASP A  34
PHE A  41
 None
 1.27A 5yn6A-4eqfA:
undetectable		 5yn6A-4eqfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		4 / 6 LEU A 259
LEU A 317
MET A 294
LEU A 299
 None
 1.06A 6f6sA-4eqfA:
undetectable
6f6sB-4eqfA:
undetectable		 6f6sA-4eqfA:
14.41
6f6sB-4eqfA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		4 / 6 MET A 294
ARG A 288
ALA A 303
LEU A 287
 None
 1.15A 6fosB-4eqfA:
undetectable		 6fosB-4eqfA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4eqf PEX5-RELATED PROTEIN
(Mus
musculus) 		4 / 6 ASP A 168
ASP A 166
ARG A 197
LYS A 119
 None
 1.39A 6g31L-4eqfA:
undetectable		 6g31L-4eqfA:
13.65