SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eqv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 261
GLY A 263
ASP A 265
ILE A 464
PRO A 333
 None
 0.86A 1c6yB-4eqvA:
undetectable		 1c6yB-4eqvA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 405
GLY A 397
LEU A 460
TYR A 480
 None
 0.90A 1jlbA-4eqvA:
undetectable		 1jlbA-4eqvA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 359
PHE A 506
VAL A 491
 None
 0.82A 1kijA-4eqvA:
undetectable		 1kijA-4eqvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  55
ASP A 151
THR A 112
ASP A  22
 None
 0.83A 1m4iA-4eqvA:
undetectable		 1m4iA-4eqvA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 128
HIS A  36
ASP A  32
 None
 0.86A 1nw5A-4eqvA:
undetectable		 1nw5A-4eqvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 370
TRP A 343
LYS A  34
 None
 1.40A 1qu2A-4eqvA:
undetectable		 1qu2A-4eqvA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 405
GLY A 397
LEU A 460
TYR A 480
 None
 0.97A 1s1xA-4eqvA:
undetectable		 1s1xA-4eqvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 261
GLY A 263
ASP A 265
ILE A 464
PRO A 333
 None
 0.90A 2nnkB-4eqvA:
undetectable		 2nnkB-4eqvA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 261
GLY A 263
ASP A 265
ILE A 464
PRO A 333
 None
 0.89A 2nnpA-4eqvA:
undetectable		 2nnpA-4eqvA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 261
GLY A 263
ASP A 265
ILE A 464
PRO A 333
 None
 0.84A 2r5qB-4eqvA:
undetectable		 2r5qB-4eqvA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 261
GLY A 263
ASP A 265
ILE A 464
PRO A 333
 None
 0.84A 2r5qD-4eqvA:
undetectable		 2r5qD-4eqvA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 155
SER A  85
PHE A 250
ILE A 110
 None
 1.29A 2v0mD-4eqvA:
undetectable		 2v0mD-4eqvA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		3 / 3 PRO A  15
GLY A  18
TYR A  41
 None
 0.67A 2vouB-4eqvA:
undetectable		 2vouB-4eqvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		3 / 3 PRO A  15
GLY A  18
TYR A  41
 None
 0.66A 2vouC-4eqvA:
undetectable		 2vouC-4eqvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 394
VAL A 491
ARG A 406
GLY A 408
 None
 0.90A 2xfsA-4eqvA:
undetectable		 2xfsA-4eqvA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 394
VAL A 491
ARG A 406
GLY A 408
 None
 0.92A 2xh9A-4eqvA:
undetectable		 2xh9A-4eqvA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 358
MET A 493
THR A 494
LEU A 391
 None
 1.15A 3ag1J-4eqvA:
undetectable		 3ag1J-4eqvA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 205
PHE A 155
LYS A 153
 None
 0.95A 3bjwG-4eqvA:
undetectable		 3bjwG-4eqvA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 261
GLY A 263
ASP A 265
ILE A 464
PRO A 333
 None
 0.80A 3d1xA-4eqvA:
undetectable		 3d1xA-4eqvA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 261
GLY A 263
ASP A 265
ILE A 464
PRO A 333
 None
 0.92A 3el4A-4eqvA:
undetectable		 3el4A-4eqvA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 327
PHE A 312
PHE A 224
TYR A 240
 None
 1.34A 3em0A-4eqvA:
undetectable		 3em0A-4eqvA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  80
SER A  79
THR A 115
PHE A  53
ILE A  72
 None
 1.20A 3iv6B-4eqvA:
undetectable		 3iv6B-4eqvA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  80
SER A  79
THR A 115
PHE A  53
ILE A  72
 None
 1.16A 3iv6D-4eqvA:
undetectable		 3iv6D-4eqvA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 299
SER A 289
ASP A 265
ASN A 290
LEU A 418
 None
 1.22A 3q87B-4eqvA:
undetectable		 3q87B-4eqvA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 192
PHE A 241
ASN A 194
GLY A 196
 None
 0.92A 4ejjA-4eqvA:
undetectable		 4ejjA-4eqvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 192
PHE A 241
ASN A 194
GLY A 196
 None
 0.92A 4ejjB-4eqvA:
undetectable		 4ejjB-4eqvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 315
ASP A 471
PRO A 216
THR A 212
 None
 0.97A 4l1aB-4eqvA:
undetectable		 4l1aB-4eqvA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		3 / 3 TRP A  65
GLN A 462
THR A  14
 None
 0.60A 4m2xA-4eqvA:
undetectable		 4m2xA-4eqvA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 261
GLY A 263
ASP A 265
ILE A 464
PRO A 333
 None
 1.01A 4njvC-4eqvA:
undetectable		 4njvC-4eqvA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 7 ASN A  42
PRO A  43
PHE A  53
PHE A  82
 None
 1.42A 4v32A-4eqvA:
undetectable		 4v32A-4eqvA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 7 ASN A  42
PRO A  43
PHE A  53
PHE A  82
 None
 1.42A 4v32B-4eqvA:
undetectable		 4v32B-4eqvA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 468
TYR A 266
SER A 307
LEU A 308
 None
 1.05A 5bphB-4eqvA:
undetectable		 5bphB-4eqvA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 361
LEU A 398
GLY A 397
LEU A 488
LEU A 460
 None
 1.22A 5dqfA-4eqvA:
undetectable		 5dqfA-4eqvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EVY_X_SALX502_1
(SALICYLATE
HYDROXYLASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 5 SER A 190
MET A 223
LEU A 207
PHE A 245
 None
 1.31A 5evyX-4eqvA:
undetectable		 5evyX-4eqvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 332
GLY A 472
TYR A 457
ASP A 471
TYR A 318
 None
 1.18A 5kvaA-4eqvA:
undetectable		 5kvaA-4eqvA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 332
GLY A 472
TYR A 457
ASP A 471
TYR A 318
 None
 1.19A 5kvaB-4eqvA:
undetectable		 5kvaB-4eqvA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 335
GLU A 510
GLU A 370
LEU A 369
LEU A 460
 None
 1.22A 5nwvA-4eqvA:
undetectable		 5nwvA-4eqvA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 279
ASP A  32
TRP A  35
HIS A  36
 None
 1.41A 5ov9B-4eqvA:
undetectable		 5ov9B-4eqvA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 358
MET A 493
THR A 494
LEU A 391
 None
 1.11A 5x1bJ-4eqvA:
undetectable		 5x1bJ-4eqvA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 358
MET A 493
THR A 494
LEU A 391
 None
 1.11A 5x1bW-4eqvA:
undetectable		 5x1bW-4eqvA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 369
VAL A 297
PHE A 395
GLY A 458
 None
 0.97A 6hd4B-4eqvA:
undetectable		 6hd4B-4eqvA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 358
MET A 493
THR A 494
LEU A 391
 None
 1.20A 6nknJ-4eqvA:
undetectable		 6nknJ-4eqvA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4eqv INVERTASE 2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 358
MET A 493
THR A 494
LEU A 391
 None
 1.21A 6nknW-4eqvA:
undetectable		 6nknW-4eqvA:
8.87