SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4er8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		4 / 8 HIS A 123
GLU A 161
HIS A  59
ALA A 159
 NI  A 201 (-3.2A)
NI  A 201 (-1.9A)
NI  A 201 (-3.3A)
None
 0.66A 2bnnA-4er8A:
undetectable
2bnnB-4er8A:
undetectable		 2bnnA-4er8A:
21.36
2bnnB-4er8A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  80
ILE A  50
PHE A  48
VAL A  18
LEU A  35
 None
 1.13A 3dzuA-4er8A:
undetectable		 3dzuA-4er8A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		4 / 7 GLY A 144
TYR A 117
VAL A 113
ARG A 139
 None
 0.82A 3elzA-4er8A:
undetectable		 3elzA-4er8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		3 / 3 HIS A 101
HIS A 112
ILE A 103
 None
 0.81A 3u52A-4er8A:
undetectable
3u52C-4er8A:
undetectable		 3u52A-4er8A:
14.31
3u52C-4er8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		4 / 6 ILE A  93
TRP A  64
TRP A  53
MET A  60
 None
 1.38A 3welA-4er8A:
undetectable		 3welA-4er8A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		4 / 6 ILE A  93
TRP A  64
TRP A  53
MET A  60
 None
 1.39A 3weoA-4er8A:
undetectable		 3weoA-4er8A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		3 / 3 ARG A   6
THR A  17
TRP A  99
 None
 1.20A 4d7hA-4er8A:
undetectable		 4d7hA-4er8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		4 / 7 PHE A 157
PHE A  15
GLY A 160
THR A  17
 None
 0.87A 4ejjA-4er8A:
undetectable		 4ejjA-4er8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		4 / 7 PHE A 157
PHE A  15
GLY A 160
THR A  17
 None
 0.87A 4ejjB-4er8A:
undetectable		 4ejjB-4er8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		4 / 5 PHE A 157
PHE A  15
GLY A 160
THR A  17
 None
 0.99A 4ejjC-4er8A:
undetectable		 4ejjC-4er8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		3 / 3 ARG A   6
THR A  17
TRP A  99
 None
 1.07A 4ug5A-4er8A:
undetectable		 4ug5A-4er8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		3 / 3 ARG A   6
THR A  17
TRP A  99
 None
 1.20A 4uglA-4er8A:
undetectable		 4uglA-4er8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		3 / 3 ARG A   6
THR A  17
TRP A  99
 None
 1.15A 5g6cA-4er8A:
undetectable		 5g6cA-4er8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4er8 TNPAREP FOR PROTEIN
(Escherichia
coli) 		4 / 5 SER A 158
ALA A 159
GLN A  95
THR A  17
 None
 1.37A 5n0tA-4er8A:
undetectable		 5n0tA-4er8A:
17.31