SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4erd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J0D_A_ERYA1498_0 (CYTOCHROME P450 3A4)	4erd	TELOMERASE ASSOCIATED PROTEIN P65 (Tetrahymena thermophila)	5 / 12	ARG A 465 PHE A 466 ILE A 381 ILE A 489 ALA A 398	G D 121 ( 3.2A) None None None None	1.06A	2j0dA-4erdA: undetectable	2j0dA-4erdA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J9D_J_ACTJ1116_0 (HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059)	4erd	TELOMERASE ASSOCIATED PROTEIN P65 (Tetrahymena thermophila)	4 / 8	LYS A 382 ILE A 499 GLU A 506 ILE A 502	None	0.86A	2j9dJ-4erdA: 4.5 2j9dK-4erdA: 3.0 2j9dL-4erdA: undetectable	2j9dJ-4erdA: 20.29 2j9dK-4erdA: 20.29 2j9dL-4erdA: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q6F_C_010C6_0 (INFECTIOUS BRONCHITIS VIRUS (IBV) MAIN PROTEASE N-[(5-METHYLISOXAZOL -3-YL)CARBONYL]ALANY L-L-VALYL-N~1~-((1R, 2Z)-4-(BENZYLOXY)-4- OXO-1-{[(3R)-2-OXOPY RROLIDIN-3-YL]METHYL }BUT-2-ENYL)-L-LEUCI NAMIDE)	4erd	TELOMERASE ASSOCIATED PROTEIN P65 (Tetrahymena thermophila)	3 / 3	ASN A 481 LEU A 480 HIS A 482	None	0.81A	2q6fB-4erdA: undetectable	2q6fB-4erdA: 17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UT5_B_LOCB502_1 (TUBULIN BETA CHAIN)	4erd	TELOMERASE ASSOCIATED PROTEIN P65 (Tetrahymena thermophila)	5 / 12	LYS A 486 LEU A 487 THR A 501 ILE A 383 ILE A 381	None	1.18A	3ut5B-4erdA: undetectable	3ut5B-4erdA: 14.84

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2J0D_A_ERYA1498_0","CYTOCHROME P450 3A4","4erd","TELOMERASE ASSOCIATED PROTEIN P65","Tetrahymena thermophila",5,"ARG A 465;PHE A 466;ILE A 381;ILE A 489;ALA A 398","  G D 121 ( 3.2A);None;None;None;None","1.06A","2j0dA-4erdA:undetectable","2j0dA-4erdA:15.38"],["2J9D_J_ACTJ1116_0","HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059","4erd","TELOMERASE ASSOCIATED PROTEIN P65","Tetrahymena thermophila",4,"LYS A 382;ILE A 499;GLU A 506;ILE A 502","None","0.86A","2j9dJ-4erdA:4.5;2j9dK-4erdA:3.0;2j9dL-4erdA:undetectable","2j9dJ-4erdA:20.29;2j9dK-4erdA:20.29;2j9dL-4erdA:20.29"],["2Q6F_C_010C6_0","INFECTIOUS BRONCHITIS VIRUS (IBV) MAIN PROTEASE;N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE","4erd","TELOMERASE ASSOCIATED PROTEIN P65","Tetrahymena thermophila",3,"ASN A 481;LEU A 480;HIS A 482","None","0.81A","2q6fB-4erdA:undetectable","2q6fB-4erdA:17.59"],["3UT5_B_LOCB502_1","TUBULIN BETA CHAIN","4erd","TELOMERASE ASSOCIATED PROTEIN P65","Tetrahymena thermophila",5,"LYS A 486;LEU A 487;THR A 501;ILE A 383;ILE A 381","None","1.18A","3ut5B-4erdA:undetectable","3ut5B-4erdA:14.84"]]