SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ern'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		5 / 11 LEU A 662
LEU A 547
HIS A 551
LEU A 693
ALA A 508
 None
 1.09A 1h9zA-4ernA:
undetectable		 1h9zA-4ernA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		5 / 11 LEU A 662
LEU A 547
HIS A 551
LEU A 693
ALA A 508
 None
 1.06A 1ha2A-4ernA:
undetectable		 1ha2A-4ernA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 701
GLU A 697
GLY A 695
ARG A 553
ALA A 694
 None
 1.19A 2bm9C-4ernA:
3.6		 2bm9C-4ernA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 701
GLU A 697
GLY A 695
ARG A 553
ALA A 694
 None
 1.18A 2bm9D-4ernA:
4.0		 2bm9D-4ernA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		5 / 9 LEU A 662
LEU A 547
HIS A 551
LEU A 693
ALA A 508
 None
 0.98A 2bxeA-4ernA:
undetectable		 2bxeA-4ernA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		5 / 10 LEU A 662
LEU A 547
HIS A 551
LEU A 693
ALA A 508
 None
 0.97A 2bxeB-4ernA:
undetectable		 2bxeB-4ernA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		5 / 9 GLU A 727
VAL A 610
ILE A 559
LEU A 617
ILE A 580
 None
 1.12A 3jw3B-4ernA:
undetectable		 3jw3B-4ernA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		4 / 8 GLU A 570
PHE A 518
ARG A 574
PHE A 703
 None
 1.17A 3mjrD-4ernA:
undetectable		 3mjrD-4ernA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		4 / 6 GLU A 636
ARG A 676
ARG A 634
ARG A 633
 None
 1.28A 5l6eA-4ernA:
undetectable
5l6eB-4ernA:
undetectable		 5l6eA-4ernA:
19.67
5l6eB-4ernA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		4 / 6 ALA A 562
GLY A 582
THR A 584
ILE A 592
 None
 0.82A 6f8cA-4ernA:
undetectable		 6f8cA-4ernA:
15.67