SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4erv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4erv RYANODINE RECEPTOR 3
(Homo
sapiens) 		4 / 6 PHE A2598
LYS A2752
LYS A2751
ALA A2748
 None
None
SO4  A2901 (-3.0A)
None
 1.21A 1hk2A-4ervA:
undetectable		 1hk2A-4ervA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4erv RYANODINE RECEPTOR 3
(Homo
sapiens) 		4 / 4 LEU A2660
THR A2661
ILE A2654
HIS A2651
 None
None
None
GOL  A2904 (-3.8A)
 1.11A 2jfaB-4ervA:
undetectable		 2jfaB-4ervA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4erv RYANODINE RECEPTOR 3
(Homo
sapiens) 		4 / 7 TYR A2743
LEU A2787
ASP A2786
SER A2625
 None
 1.36A 3lslA-4ervA:
undetectable
3lslD-4ervA:
undetectable		 3lslA-4ervA:
21.92
3lslD-4ervA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4erv RYANODINE RECEPTOR 3
(Homo
sapiens) 		4 / 7 SER A2625
TYR A2743
LEU A2787
ASP A2786
 None
 1.41A 3lslA-4ervA:
undetectable
3lslD-4ervA:
undetectable		 3lslA-4ervA:
21.92
3lslD-4ervA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4erv RYANODINE RECEPTOR 3
(Homo
sapiens) 		4 / 8 SER A2625
PHE A2788
ILE A2796
VAL A2686
 None
 0.97A 4dx7B-4ervA:
undetectable		 4dx7B-4ervA:
11.50