SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4es1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4es1 BH0342 PROTEIN
(Bacillus
halodurans) 		4 / 7 LEU A  66
SER A  65
ASP A   8
PHE A  39
 None
 1.25A 1ismB-4es1A:
undetectable		 1ismB-4es1A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 4es1 BH0342 PROTEIN
(Bacillus
halodurans) 		4 / 8 LEU A  71
THR A   6
LEU A   2
VAL A  38
 None
 0.78A 1sn5C-4es1A:
undetectable		 1sn5C-4es1A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4es1 BH0342 PROTEIN
(Bacillus
halodurans) 		4 / 8 ILE A   5
VAL A  23
TYR A  30
CYH A  41
 None
 0.92A 2xz5A-4es1A:
undetectable
2xz5C-4es1A:
undetectable		 2xz5A-4es1A:
18.43
2xz5C-4es1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4es1 BH0342 PROTEIN
(Bacillus
halodurans) 		4 / 8 ILE A   5
VAL A  23
TYR A  30
CYH A  41
 None
 0.92A 2xz5C-4es1A:
undetectable
2xz5D-4es1A:
undetectable		 2xz5C-4es1A:
18.43
2xz5D-4es1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 4es1 BH0342 PROTEIN
(Bacillus
halodurans) 		4 / 8 VAL A  23
TYR A  30
CYH A  41
ILE A   5
 None
 0.86A 4afgD-4es1A:
undetectable
4afgE-4es1A:
undetectable		 4afgD-4es1A:
16.88
4afgE-4es1A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4es1 BH0342 PROTEIN
(Bacillus
halodurans) 		4 / 8 VAL A  23
TYR A  30
CYH A  41
ILE A   5
 None
 1.04A 4aftD-4es1A:
undetectable
4aftE-4es1A:
undetectable		 4aftD-4es1A:
17.97
4aftE-4es1A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4es1 BH0342 PROTEIN
(Bacillus
halodurans) 		4 / 8 VAL A  23
TYR A  30
CYH A  41
ILE A   5
 None
 1.14A 4bqtC-4es1A:
undetectable
4bqtD-4es1A:
undetectable		 4bqtC-4es1A:
17.97
4bqtD-4es1A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4es1 BH0342 PROTEIN
(Bacillus
halodurans) 		4 / 8 LEU A  71
THR A   6
LEU A   2
VAL A  38
 None
 0.73A 4ik6B-4es1A:
undetectable		 4ik6B-4es1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4es1 BH0342 PROTEIN
(Bacillus
halodurans) 		4 / 8 LEU A  71
THR A   6
LEU A   2
VAL A  38
 None
 0.72A 4ik7B-4es1A:
undetectable		 4ik7B-4es1A:
23.02