SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4es6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4es6 UROPORPHYRINOGEN-III
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 243
VAL A  27
GLY A  23
ALA A  25
SER A  21
 None
 1.28A 1pxxB-4es6A:
undetectable		 1pxxB-4es6A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4es6 UROPORPHYRINOGEN-III
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 243
VAL A  27
GLY A  23
ALA A  25
SER A  21
 None
 1.27A 1pxxD-4es6A:
undetectable		 1pxxD-4es6A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4es6 UROPORPHYRINOGEN-III
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 150
LEU A 116
LEU A 117
PHE A 122
ILE A 135
 None
 0.84A 2v0mC-4es6A:
undetectable		 2v0mC-4es6A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 4es6 UROPORPHYRINOGEN-III
SYNTHASE
(Pseudomonas
aeruginosa) 		3 / 3 PRO A  33
THR A   9
LEU A 174
 None
CL  A 301 (-4.4A)
None
 0.68A 3ttrA-4es6A:
undetectable		 3ttrA-4es6A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4es6 UROPORPHYRINOGEN-III
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 169
SER A  31
ASP A  38
ILE A  37
 None
 1.21A 3uj7B-4es6A:
undetectable		 3uj7B-4es6A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4es6 UROPORPHYRINOGEN-III
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 246
GLY A 237
ILE A 233
VAL A 220
 None
 0.79A 4r21A-4es6A:
undetectable		 4r21A-4es6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4es6 UROPORPHYRINOGEN-III
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 8 THR A   9
LEU A   8
LEU A 243
LEU A  18
 CL  A 301 (-4.4A)
CL  A 301 ( 4.6A)
None
None
 0.78A 4z90F-4es6A:
undetectable
4z90G-4es6A:
undetectable
4z90H-4es6A:
undetectable
4z90I-4es6A:
undetectable
4z90J-4es6A:
undetectable		 4z90F-4es6A:
19.57
4z90G-4es6A:
19.57
4z90H-4es6A:
19.57
4z90I-4es6A:
19.57
4z90J-4es6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4es6 UROPORPHYRINOGEN-III
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 5 SER A  88
ARG A  68
GLY A  70
GLU A  72
 None
 1.18A 5btiA-4es6A:
undetectable
5btiB-4es6A:
4.5		 5btiA-4es6A:
20.24
5btiB-4es6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4es6 UROPORPHYRINOGEN-III
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 197
GLY A 193
GLY A 191
LEU A 186
VAL A 215
 None
 1.03A 5o96G-4es6A:
2.6
5o96H-4es6A:
2.4		 5o96G-4es6A:
22.38
5o96H-4es6A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4es6 UROPORPHYRINOGEN-III
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  27
LEU A   6
LEU A   8
LEU A 244
LEU A 247
 None
None
CL  A 301 ( 4.6A)
None
None
 0.91A 6f5uA-4es6A:
undetectable
6f5uB-4es6A:
undetectable		 6f5uA-4es6A:
15.51
6f5uB-4es6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4es6 UROPORPHYRINOGEN-III
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A  27
LEU A   6
LEU A   8
LEU A 244
 None
None
CL  A 301 ( 4.6A)
None
 0.69A 6g9bA-4es6A:
undetectable
6g9bB-4es6A:
undetectable		 6g9bA-4es6A:
15.51
6g9bB-4es6A:
16.67